NCT00155194

Evaluation of Immune Function in Biliary Atresia Children With Prolonged Jaundice

Impaired T-Lymphocyte Proliferative Function in Biliary Atresia Children With Prolonged Jaundice

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 30 (planned)
• Sponsor: National Taiwan University Hospital · Academic / Other
• Sex: All
• Age: 1 Year
• Healthy volunteers: Not accepted

Summary

Null hypothesis of this study: Biliary atresia patients with cholestatic jaundice do not have systemic immunity defect.

Detailed description

Biliary atresia patients with cholestatic jaundice were noted to have increased incidence of infectious complications. Previous animal models of bile duct ligation with acute jaundice ever demonstrated impairment of both humoral and cellular immune function. We performed the immunity study in biliary atresia patients due to the lack of comprehensive systemic immunity study in pediatric cholestatic model. Systemic humoral immunity (total serum IgG, IgA, IgM, C3 and C4), specific cellular immunity (lymphocyte classification, mitogen response, cytokines level after PHA stimulation test), and non-specific cellular immunity (absolute neutrophil count, PMN CD11b/CD18 expression level, PMN superoxide release function, and PMN phagocytosis function) were tested. Association with serum bilirubin level, nutritional status and blood biochemical values were tested to see the relation between systemic immune function and cholestatic jaundice.

Conditions

• Biliary Atresia

Timeline

• Start date: 2004-04-01
• First posted: 2005-09-12
• Last updated: 2005-09-12

Locations

1 site across 1 country: Taiwan