NCT00122031

Deep Brain Stimulation for Treatment-Refractory Major Depression

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: University Hospital, Bonn · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study will investigate the use of deep brain stimulation (DBS) to reduce symptom severity and enhance the quality of life for patients with treatment-refractory major depression.

Detailed description

Despite advances in pharmacotherapy and psychotherapy for major depression, a substantial number of patients fail to improve significantly even after years of conventional and experimental interventions. Bilateral deep brain stimulation (DBS) to the region of the anterior capsule/ventral striatum is an adjustable and reversible procedure that may be a more effective treatment for patients with major depression. This study will determine the effectiveness, safety, and tolerability of DBS in patients with treatment-refractory major depression.

Conditions

• Depression

Interventions

Type	Name	Description
DEVICE	Deep Brain Stimulation with Medtronic Activa Neurostimulator	Deep brain stimulation (DBS) at 130 Hz

Timeline

• Start date: 2005-07-01
• Primary completion: 2009-04-01
• Completion: 2011-01-01
• First posted: 2005-07-21
• Last updated: 2012-06-14

Locations

1 site across 1 country: Germany