NCT00111371

Dopaminergic Enhancement of Learning and Memory in Healthy Adults and Patients With Dyslexia

Dopaminergic Enhancement of Learning and Memory (LL_001, Project on Dyslexia)

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: University Hospital Muenster · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

This study aims to determine whether levodopa, in combination with a high frequency training of (grammatical) rules, is effective in boosting learning success in healthy subjects and whether this kind of training in combination with levodopa improves reading and spelling abilities of patients with dyslexia.

Detailed description

Prior work by our group shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind trial, we probe whether daily administration of levodopa, coupled with a training of grammatical rules, improves the training success in healthy adults as compared to placebo administration. In the second step of this study, patients with dyslexia will be trained with the identical protocol. We postulate that the combination of intensive training in language rules and levodopa improves the reading, writing, and spelling abilities of patients with dyslexia.

Conditions

• Dyslexia

Interventions

Type	Name	Description
DRUG	Levodopa

Timeline

• Start date: 2005-01-01
• Completion: 2015-10-01
• First posted: 2005-05-20
• Last updated: 2014-12-05

Locations

1 site across 1 country: Germany