NCT00102674

Pharmacokinetics/Pharmacodynamics (PK/PD) of Cangrelor

The Pharmacokinetics and Pharmacodynamics of a Cangrelor Bolus Plus Infusion in Healthy Volunteers

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 40 (planned)
• Sponsor: The Medicines Company · Industry
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The purposes of this study are to: * Evaluate the tolerability of two cangrelor regimens. * Compare the PD of cangrelor regimens with oral clopidogrel.

Detailed description

The purposes of this study are: * To evaluate the tolerability of two cangrelor regimens of bolus plus infusion (A and B). * To characterize the pharmacokinetics of Cangrelor (A and B). * To compare the pharmacodynamics of cangrelor regimens with that of an oral 600 mg dose of clopidogrel (A, B, C and D). * To determine the effect of prior cangrelor treatment on the pharmacodynamics of clopidogrel (C and D). * To determine the effect of prior clopidogrel treatment on the pharmacodynamics of cangrelor (Group D). * To determine the effects of concomitant clopidogrel and cangrelor exposure on the pharmacodynamics of clopidogrel (Group D).

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	cangrelor

Timeline

• Start date: 2005-03-01
• Completion: 2005-05-01
• First posted: 2005-02-01
• Last updated: 2011-08-16

Locations

1 site across 1 country: United States