NCT00071643

Preventing Post-Stroke Depression

Prevention of Post-Stroke Depression - Treatment Strategy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 201 (actual)
• Sponsor: Robert G. Robinson · Academic / Other
• Sex: All
• Age: 31 Years – 89 Years
• Healthy volunteers: Not accepted

Summary

This study will evaluate the effectiveness of both drug and non-drug treatments in preventing depression after a stroke.

Detailed description

The development of depression after a stroke is a serious condition that can have negative effects on thought, emotions, and overall daily functioning, particularly in the first year following the stroke. Evidence suggests that antidepressants may be used to prevent post-stroke depression. This study will treat nondepressed stroke patients with antidepressants or problem solving therapy (PST) to determine the most effective treatments for preventing depression. Participants in this study will be randomly assigned to receive PST, escitalopram, or placebo (an inactive pill) for 12 months. Participants who display depressive symptoms for 2 weeks or more will be removed from the study. After 12 months, treatment will be discontinued and participants will be monitored for an additional 6 months.

Conditions

• Depression
• Cerebrovascular Accident

Interventions

Type	Name	Description
BEHAVIORAL	Problem Solving Therapy	Problem solving therapy aims to make patients aware of symptoms of problems and link those with behaviors associated with solving them.
DRUG	Escitalopram	Participants will receive escitalopram, a selective serotonin reuptake inhibitor.
OTHER	Placebo	Participants will receive a placebo pill.

Timeline

• Start date: 2002-09-01
• Primary completion: 2008-11-01
• Completion: 2008-11-01
• First posted: 2003-10-30
• Last updated: 2017-09-05

Locations

3 sites across 1 country: United States