NCT00067899

Oxidative Stress and Vitamin E Requirements

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 99 (planned)
• Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · NIH
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine if oxidative stress derived from cigarette smoking increases vitamin E requirements. The study will also assess the role of vitamin C in modulating vitamin E requirements. Vitamin E requirements will be assessed by measuring vitamin E in plasma as well as by measuring the excreted vitamin E metabolite in the urine.

Detailed description

We will be investigating the fractional disappearance rate of tocopherols in cigarette smokers compared to nonsmokers. This will be accomplished by supplementing individuals with deuterium labeled alpha- and gamma-tocopherols. Quantification of plasma tocopherols as well as urinary metabolites, alpha- and gamma-carboxy ethyl hydroxychromanol, will be determined using liquid chromatography/mass spectrometry analysis. In addition, the role of vitamin C as it pertains to its influence on the fraction disappearance rate of vitamin E will also be evaluated.

Conditions

• Smoking

Interventions

Type	Name	Description
DRUG	Vitamin E with and without Vitamin C

Timeline

• Start date: 2000-09-01
• Primary completion: 2005-12-01
• Completion: 2005-12-01
• First posted: 2003-09-08
• Last updated: 2013-06-19

Locations

1 site across 1 country: United States