NCT00033098

Cocaine-Metyrapone Interaction Study - 1

Cocaine-Metyrapone Interaction Study

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 12 (planned)
• Sponsor: National Institute on Drug Abuse (NIDA) · NIH
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine the safety of two consecutive days of metyrapone (MRP) in subjects who may use cocaine concurrently.

Detailed description

To evaluate the safety of metyrapone (MRP) for using in an outpatient study in which participants would be given 2 750 mg doses of MRP per week. Secondary study goals are to evaluate the possible efficacy of MRP as a treatment for cocaine dependence and to compare 3 factors hypothesized to induce cocaine craving: cocaine cues, stress, and cocaine itself. This study will utilize a Double Blind, placebo-controlled crossover design with 3 factors: 1) medication 2) relapse trigger and 3) infusion for an 11 day in-patient treatment.

Conditions

• Cocaine-Related Disorders
• Infusions, Intravenous

Interventions

Type	Name	Description
DRUG	Metyrapone

Timeline

• Start date: 2001-11-01
• Completion: 2002-05-01
• First posted: 2002-04-08
• Last updated: 2017-01-11

Locations

1 site across 1 country: United States