Trials / Completed
CompletedNCT00032123
Erlotinib in Treating Patients With Locally Advanced or Metastatic Stomach Cancer or Gastroesophageal Junction Cancer
A Phase II Study Of OSI-774 (NSC 718781) In Unresectable Or Metastatic Adenocarcinoma Of The Stomach And Gastroesophageal Junction
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- —
- Sponsor
- SWOG Cancer Research Network · Network
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Biological therapies such as erlotinib may interfere with the growth of tumor cells and slow the growth of the tumor. PURPOSE: Phase II trial to study the effectiveness of erlotinib in treating patients who have locally advanced or metastatic stomach cancer or cancer of the gastroesophageal junction.
Detailed description
OBJECTIVES: * Determine the overall response rate of patients with locally advanced or metastatic adenocarcinoma of the stomach or gastroesophageal junction treated with erlotinib. (Gastric stratum temporarily closed to accrual as of 03/01/2003.) * Determine the frequency and severity of toxic effects of this drug in these patients. * Determine the overall survival and time to treatment failure in patients treated with this drug. * Determine the value of intratumoral expression of epidermal growth factor receptor in predicting patient response to this drug. OUTLINE: This is a multicenter study. Patients are stratified according to cancer site (stomach vs gastroesophageal junction). (The gastric stratum is temporarily closed to accrual as of 03-01-2003.) Patients receive oral erlotinib once daily. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients are followed every 6 months for 3 years. PROJECTED ACCRUAL: A total of 40-80 patients (20-40 per stratum) will be accrued for this study within 14-40 months. (The gastric stratum is temporarily closed to accrual as of 03-01-2003.)
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | erlotinib hydrochloride |
Timeline
- Start date
- 2002-06-01
- Completion
- 2006-05-01
- First posted
- 2003-01-27
- Last updated
- 2013-06-24
Locations
107 sites across 2 countries: United States, Canada
Source: ClinicalTrials.gov record NCT00032123. Inclusion in this directory is not an endorsement.