NCT00030680

Radiation Therapy in Treating Patients With Aggressive Fibromatoses

Phase II Pilot Study Of Moderate Dose Radiotherapy For Inoperable Aggressive Fibromatoses

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: European Organisation for Research and Treatment of Cancer - EORTC · Network
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. PURPOSE: Phase II trial to study the effectiveness of radiation therapy in treating patients who have aggressive fibromatoses.

Detailed description

OBJECTIVES: * Determine the efficacy of moderate-dose radiotherapy, in terms of local control, in patients with aggressive fibromatoses. * Determine the acute and late side-effects of this regimen in these patients. OUTLINE: This is a multicenter study. Patients receive radiotherapy 5 days a week for 5.5 weeks for a total of 56 Gy in 28 fractions. Patients are followed every 3 months for 2 years and then every 6 months thereafter. PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study within 3 years.

Conditions

• Desmoid Tumor

Interventions

Type	Name	Description
RADIATION	radiation therapy

Timeline

• Start date: 2001-11-01
• Primary completion: 2012-03-01
• Completion: 2012-03-01
• First posted: 2003-01-27
• Last updated: 2013-08-27

Locations

21 sites across 7 countries: Belgium, France, Germany, Netherlands, Poland, Switzerland, United Kingdom