NCT00018759

Treatment Effects on Platelet Calcium in Hypertensive and Depressed Patients

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: —
• Sponsor: US Department of Veterans Affairs · Federal
• Sex: Male
• Age: 25 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study aims to determine if treatment with an SSRI antidepressant medication, paroxetine, is associated with cellular calcium response to serotonin, platelet serotonin receptors, and improvement in mood in depressed patients with or without hypertension. It is hypothesized that platelets of hypertensive patients with depressive symptomatology with be hyper-responsive to serotonin. Additionally, treatment with an SSRI antidepressant is expected to produce a down-regulation of the serotonin receptor with an associated reduction in platelet cytosolic calcium response as well as improved mood.

Conditions

• Depression
• Hypertension

Interventions

Type	Name	Description
DRUG	paroxetine
BEHAVIORAL	ongoing psychological screening

Timeline

• Start date: 2001-03-01
• Completion: 2003-10-01
• First posted: 2001-07-05
• Last updated: 2009-01-21

Locations

1 site across 1 country: United States