NCT00018499

Genotype Influence on Recovery After Traumatic Brain Injury

The Influence of APOE Genotype on Recovery After Traumatic Brain Injury

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: —
• Sponsor: US Department of Veterans Affairs · Federal
• Sex: All
• Age: 17 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

Genetic differences in response to brain injury may reasonably be expected to play a role in the initial consequences of traumatic brain injury and in the rate of recovery from such injury.

Detailed description

Polymorphisms in the Apolipoprotein E gene encode functional variants which differentially determine the rate at which neuronal repair can occur, and are associated with differences in expression of neurodegenerative processes, including traumatic brain injury. It is proposed that the accuracy of prediction of outcome after head injury will be significantly increased by inclusion of APOE genotype alone, or in combination with other variables such as severity of head injury, cognitive, electroencephalographic or neuroradiologic measures, or treatment strategies.

Conditions

• Brain Injury

Timeline

• Start date: 1998-10-01
• Completion: 2001-10-01
• First posted: 2001-07-05
• Last updated: 2009-01-21

Locations

1 site across 1 country: United States