NCT00015457

Amlodipine Plus Botulinum Toxin for Focal Dystonia

Trial of Amlodipine Combined With Botulinum Toxin Injections for Focal Dystonia

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) · NIH
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Objective: To determine if the calcium channel blockers, amlodipine can augment the effect of botulinum toxin injections in the treatment of focal dystonia. Study Population: 20 patients with cervical dystonia Design: Double-bind, placebo-controlled clinical trail. Outcome measures: For patients: dystonia rating scales (Twistrs, Fahn-Marsden dystonia scale, NINDS subjective patient rating scale), and hand grip strength. For healthy volunteers: Amplitude of EDB MEP.

Detailed description

Objective: To determine if the calcium channel blocker, amlodipine can augment the effect of botulinum toxin injections in the treatment of focal dystonia. Study Population: 20 patients with cervical dystonia Design: Double-bind, placebo-controlled clinical trail. Outcome measures: dystonia rating scales (TWISTRS)

Conditions

• Focal Dystonia

Interventions

Type	Name	Description
DRUG	Amlodipine plus Botulinum toxin

Timeline

• Start date: 2001-04-01
• Primary completion: 2009-04-01
• First posted: 2001-04-19
• Last updated: 2013-04-01
• Results posted: 2013-04-01

Locations

1 site across 1 country: United States