NCT00006273

Study of Total Energy Expenditure in Infants and Children With Moderate to Severe Cystic Fibrosis

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 60 (planned)
• Sponsor: National Center for Research Resources (NCRR) · NIH
• Sex: All
• Age: 0 Years – 10 Years
• Healthy volunteers: Accepted

Summary

OBJECTIVES: I. Compare the resting energy expenditure using respiratory calorimetry in infants and children with moderate to severe cystic fibrosis versus age matched healthy controls. II. Determine the total energy expenditure and energy spent on physical activity using the doubly labeled water method in these patient populations.

Detailed description

PROTOCOL OUTLINE: Patients and healthy controls receive an oral dose of doubly labeled water following initial urine collection on day 1. Patients undergo additional urine collection at 4-6 hours following doubly labeled water consumption and then daily for 7 days. Additionally, at the beginning of the study, patients and healthy controls undergo respiratory calorimetry over approximately 45 minutes at rest, starting approximately 2-3 hours after the last meal consumption and last use of aerosol bronchodilators (if required).

Conditions

• Cystic Fibrosis

Timeline

• Start date: 1996-06-01
• First posted: 2000-09-12
• Last updated: 2005-06-24

Locations

1 site across 1 country: United States