NCT00006270

Study of the Approximate Entropy of Adrenocorticotropic Hormone and Cortisol Secretion in Patients With Head Injury

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 32 (planned)
• Sponsor: National Center for Research Resources (NCRR) · NIH
• Sex: All
• Age: 20 Years – 35 Years
• Healthy volunteers: Not accepted

Summary

OBJECTIVES: I. Determine the randomness of adrenocorticotropic hormone (ACTH) and cortisol secretion using approximate entropy in patients who have sustained a head injury. II. Determine the correlation between randomness of ACTH and cortisol secretion and stages of sleep in these patients.

Detailed description

PROTOCOL OUTLINE: Patients are stratified according to type of injury (closed head injury due to trauma vs vascular accidents). Patients are admitted two times for overnight assessment. Admission 1: Patients receive cosyntropin IV. Blood is drawn at 30 and 60 minutes after IV infusion. Patients receive oral metyrapone before sleep. A sham sleep study is conducted through the night and patients' blood is drawn in the morning. Admission 2: At least 2 weeks after admission 1, patients return for an overnight admission. Starting in the evening, blood is drawn every 15 minutes for 12 hours. A sleep study is conducted through the night.

Conditions

• Brain Injury
• Craniocerebral Trauma

Interventions

Type	Name	Description
DRUG	cosyntropin
DRUG	metyrapone

Timeline

• Start date: 1998-02-01
• First posted: 2000-09-12
• Last updated: 2005-06-24

Locations

2 sites across 1 country: United States