NCT00005890

Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 56 (planned)
• Sponsor: National Center for Research Resources (NCRR) · NIH
• Sex: All
• Age: 1 Month – 18 Years
• Healthy volunteers: Not accepted

Summary

OBJECTIVES: I. Examine adrenal cortical function and the incidence of adrenal dysfunction in children with septic shock. II. Examine the mortality, length of stay in the PICU, and incidence of multiorgan failure in children with adrenal dysfunction and septic shock.

Detailed description

PROTOCOL OUTLINE: Patients undergo a corticotropin stimulation test within 8 hours of admission to the PICU. Blood samples for plasma cortisol and corticotropin levels are drawn at time 0 followed by corticotropin 1-24 IV. Additional cortisol levels are drawn at 30 and 60 minutes. Corticotropin is measured by immunoradiometric assay and cortisol is measured by radioimmunoassay. Mean arterial blood pressure, heart rate, and respiratory rate are recorded at baseline and at 60 minutes. Patients receive routine management for septic shock and multiple organ system failure.

Conditions

• Septic Shock

Interventions

Type	Name	Description
DRUG	corticotropin

Timeline

• Start date: 1996-03-01
• First posted: 2000-06-05
• Last updated: 2005-06-24

Locations

1 site across 1 country: United States