NCT00004353

Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 35 (estimated)
• Sponsor: National Center for Research Resources (NCRR) · NIH
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

OBJECTIVES: I. Study the metabolism of pyruvate and related problems in patients with lactic acidemia. II. Define the nature of the metabolic defect.

Detailed description

PROTOCOL OUTLINE: Patients fast for 6 hours. Glucagon IM is administered after the 6 hour fast. Glucose level is measured at 0, 15, 30, 45, 60, and 90 minutes. In children of sufficient size, alanine and lactic acid should also be measured at each or most of these time points. Fasting continues for at least 18 hours. Glucagon IM is administered again at end of fast. Glucose level is measured at time 0, 15, 30, 45, 60, and 90 minutes.

Conditions

• Mitochondrial Myopathy
• MELAS Syndrome
• Lactic Acidosis

Timeline

• Start date: 1978-12-01
• First posted: 1999-10-19
• Last updated: 2008-07-10

Locations

1 site across 1 country: United States