MELAS Syndrome

18 registered clinical trials studyying MELAS Syndrome — 4 currently recruiting.

Status	Trial	Sponsor	Phase
Recruiting	A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic A NCT06792500	George Washington University	Phase 1 / Phase 2
Recruiting	A Study to Assess TTI-0102 vs Placebo in MELAS Patients NCT06644534	Thiogenesis Therapeutics, Inc.	Phase 2
Not Yet Recruiting	Effectiveness of Ketogenic Diet in MELAS Syndrome NCT06013397	Second Affiliated Hospital, School of Medicine, Zhejiang University	N/A
Unknown	Clinical Long Term Evaluation of Glutamine Supplement in MELAS Syndrome NCT05255328	Hospital Universitario 12 de Octubre	N/A
Completed	Glutamine Supplement in MELAS (Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes) Syndro NCT04948138	Jesús González de la Aleja Tejera	N/A
Completed	L-Citrulline Dose Finding Safety Study in MELAS NCT03952234	Baylor College of Medicine	Phase 1
Completed	The KHENERGYZE Study NCT04165239	Khondrion BV	Phase 2
Completed	A Phase Ia/Ib, SAD and MAD Study of of KL1333 in Healthy Subjects and Patients With Primary Mitochondrial Dise NCT03888716	Abliva AB	Phase 1
Completed	Safety, Tolerability and Pharmacokinetic Study of KL1333 in Healthy Male Volunteers NCT03056209	Yungjin Pharm. Co., Ltd.	Phase 1
Unknown	Mitochondrial nt3243 A>G Mutation in Taiwan NCT02114554	National Taiwan University Hospital	—
Completed	L-arginine Therapy on Endothelium-dependent Vasodilation & Mitochondrial Metabolism in MELAS Syndrome NCT01603446	The Hospital for Sick Children	Phase 2
Completed	Ketones & Mitochondrial Heteroplasmy NCT01252979	The University of Texas Health Science Center, Houston	EARLY_Phase 1
Completed	Responses to Influenza Vaccine in Patients With Mitochondrial Disorders (MELAS) NCT01831934	Stanford University	Phase 4
Completed	Nitric Oxide Production in MELAS Syndrome NCT01339494	Baylor College of Medicine	EARLY_Phase 1
Completed	Study of Idebenone in the Treatment of Mitochondrial Encephalopathy Lactic Acidosis & Stroke-like Episodes NCT00887562	Michio Hirano	Phase 2
Recruiting	Global Registry and Natural History Study for Mitochondrial Disorders NCT05554835	LMU Klinikum	—
Unknown	Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome NCT00068913	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Phase 2
Completed	Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia NCT00004353	National Center for Research Resources (NCRR)	—