| Not Yet Recruiting | A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use Nausea and Vomiting, Obesity | Phase 3 | 2026-02-25 |
| Not Yet Recruiting | Open Label Study to Investigate the Safety and Efficacy of Ponesimod in Moderate-to-Severe Chronic Plaque Psor Moderate-to-severe Chronic Plaque Psoriasis | Phase 3 | 2026-01-01 |
| Recruiting | An Eight-Week Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Dry Eye | Phase 2 | 2025-10-01 |
| Recruiting | Study to Evaluate the Efficacy and Safety of VQW-765 for the On-Demand Treatment of Social Anxiety Disorder Social Anxiety Disorder (SAD) | Phase 3 | 2025-09-22 |
| Recruiting | Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertens Hypertension, Uncontrolled Hypertension | Phase 2 | 2025-09-15 |
| Recruiting | Randomized Withdrawal Study in Patients With Schizophrenia Schizophrenia | Phase 3 | 2025-05-14 |
| Active Not Recruiting | Treatment of Charcot-Marie-Tooth Disease, Axonal, Type 2S (CMT2S) in an Individual Patient Charcot Marie Tooth Disease (CMT), Neuromuscular Diseases (NMD) | Phase 1 / Phase 2 | 2025-05-13 |
| Active Not Recruiting | Safety, Tolerability and Efficacy of Trichostatin A in Patients With Mild to Severe Onychomycosis Onychomycosis of Toenail | Phase 2 | 2025-05-05 |
| Recruiting | Evaluating the Effects of Tasimelteon vs. Placebo in Treating Pediatric Insomnia Insomnia Disorder | Phase 3 | 2025-04-21 |
| Recruiting | Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Dis Major Depressive Disorder (MDD) | Phase 3 | 2025-03-03 |
| Completed | A Study to Measure the Effects of Using Tradipitant on Nausea and Vomiting After GLP-1R Agonist Use Obesity | Phase 2 | 2025-02-25 |
| Recruiting | Evaluating the Effects of Tasimelteon Vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD) and the CRY1Δ11 Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Chronobiology Disorders | Phase 3 | 2024-10-08 |
| Completed | Pharmacokinetic Study of VHX-896 and Iloperidone Tablets Under Steady-State Conditions Schizophrenia, Bipolar I Disorder | Phase 1 | 2024-07-11 |
| Unknown | A Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye Dry Eye | Phase 2 | 2024-02-29 |
| Recruiting | Open Label Safety Study of Tradipitant in Idiopathic and Diabetic Gastroparesis Idiopathic Gastroparesis, Diabetic Gastroparesis, Gastroparesis | Phase 3 | 2024-01-09 |
| Completed | Motion Serifos: A Study to Investigate the Efficacy of Tradipitant in Participants Affected by Motion Sickness Motion Sickness | Phase 3 | 2023-09-09 |
| Recruiting | Safety and Tolerability of Open-Labeled Iloperidone in Adolescents Schizophrenia, Bipolar I Disorder | Phase 4 | 2023-05-24 |
| Active Not Recruiting | Motion Delos: An Open Label Safety and Efficacy of Tradipitant in Participants Affected by Motion Sickness Motion Sickness | Phase 3 | 2023-02-27 |
| Completed | Food Effect Study of VHX-896 in Healthy Volunteers Healthy | Phase 1 | 2022-06-21 |
| Withdrawn | A Study to Evaluate Iloperidone for the Treatment of Parkinson's Disease Psychosis Parkinson Disease Psychosis | Phase 2 | 2022-06-01 |
| Completed | Bioequivalence Study Between Tasimelteon Capsule Formulation and Liquid Suspension Formulation in Healthy Volu Healthy | Phase 1 | 2022-05-18 |
| Terminated | Study to Evaluate the Long-Term Safety and Efficacy of Imsidolimab (ANB019) in the Treatment of Subjects With Generalized Pustular Psoriasis | Phase 3 | 2022-04-21 |
| Completed | Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Subjects With GPP Generalized Pustular Psoriasis | Phase 3 | 2022-04-14 |
| Completed | Motion Syros: A Study to Investigate the Efficacy of Tradipitant in Subjects Affected by Motion Sickness Motion Sickness | Phase 3 | 2021-11-15 |
| Unknown | Evaluating the Effects of Tasimelteon in Individuals With Autism Spectrum Disorder (ASD) and Sleep Disturbance Autism Spectrum Disorder, Sleep Disorder, Neurological Disorder | Phase 3 | 2021-07-28 |
| Completed | A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Participants With Hidr Hidradenitis Suppurativa | Phase 2 | 2021-07-07 |
| Completed | Bioequivalence Study Between VHX-896 Tablets and Iloperidone Tablets in Healthy Volunteers Healthy | Phase 1 | 2021-06-30 |
| Completed | A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Participants With Acne Acne Vulgaris | Phase 2 | 2021-05-15 |
| Terminated | A Study to Evaluate of the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Acneiform Rash Acneiform Eruptions | Phase 2 | 2021-05-04 |
| Completed | Evaluation of Efficacy and Safety of Iloperidone in the Acute Treatment of Manic or Mixed Episodes Associated Bipolar I Disorder | Phase 3 | 2021-03-22 |
| Completed | Evaluating the Effects of VQW-765 vs. Placebo in Performance Anxiety Performance Anxiety | Phase 2 | 2021-02-23 |
| Completed | Effects of Tradipitant on Satiation, Gastric Volume, Gastric Accommodation, and Gastric Emptying in Healthy Vo Healthy Volunteer | Phase 1 / Phase 2 | 2021-02-01 |
| Terminated | A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Participants With Icht Ichthyosis | Phase 2 | 2021-01-25 |
| Completed | A Study to Evaluate Iloperidone Long-acting Injection (LAI) for the Treatment of Schizophrenia Schizophrenia | Phase 1 | 2021-01-13 |
| Recruiting | Evaluating the Effects of Tasimelteon vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD) Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Chronobiology Disorders | Phase 3 | 2020-12-09 |
| Completed | Safety and Efficacy of VSJ-110 in the Treatment of Allergic Conjunctivitis in Adults With a History of Ocular Allergic Conjunctivitis | Phase 2 | 2020-11-21 |
| Completed | WGS Analysis of COVID-19 Positive Patients Coronavirus Infection, COVID-19 | — | 2020-08-03 |
| Enrolling By Invitation | ODYSSEY: A Study to Investigate the Efficacy of Tradipitant in Treating Severe or Critical COVID-19 Infection Coronavirus Infection | Phase 3 | 2020-04-13 |
| Terminated | Evaluating the Effects of Tradipitant vs. Placebo in Atopic Dermatitis (EPIONE2) Atopic Dermatitis | Phase 3 | 2019-10-21 |
| Completed | Evaluating a New Iloperidone Titration Scheme in Bipolar I Disorder or Schizophrenia Bipolar I Disorder, Schizophrenia | Phase 1 | 2019-10-07 |
| Completed | Evaluating the Safety and Efficacy of Tradipitant vs. Placebo in Idiopathic and Diabetic Gastroparesis Idiopathic Gastroparesis, Diabetic Gastroparesis, Gastroparesis | Phase 3 | 2019-08-20 |
| Completed | A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in Adults With Palmoplantar Pustulosis Palmoplantar Pustulosis | Phase 2 | 2019-05-20 |
| Completed | A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in Adults With Generalized Pustular Psoria Generalized Pustular Psoriasis | Phase 2 | 2019-01-30 |
| Completed | Motion Sifnos: A Study to Investigate the Efficacy of Tradipitant in Subjects Affected by Motion Sickness Motion Sickness | Phase 2 | 2018-12-20 |
| Recruiting | Tolerability Study of Trichostatin A In Subjects With Relapsed or Refractory Hematologic Malignancies Relapsed or Refractory Hematologic Malignancies | Phase 1 | 2018-09-27 |
| Completed | Evaluation of Next-Day Residual Effects of Tasimelteon Compared With Placebo and Active Control in Healthy Sub Healthy Volunteers | Phase 1 | 2018-07-19 |
| Completed | Evaluating the Effects of Tradipitant vs. Placebo in Atopic Dermatitis (EPIONE) Atopic Dermatitis | Phase 3 | 2018-07-09 |
| Completed | Evaluating the Effects of Tasimelteon vs. Placebo on Jet Lag Type Insomnia Jet Lag Type Insomnia | Phase 3 | 2017-10-16 |
| Completed | Study to Assess the Efficacy of VLY-686 in Relieving Symptoms of Gastroparesis Gastroparesis | Phase 2 | 2016-11-01 |
| Completed | Study of the Pharmacokinetics and Safety of Tasimelteon in Children and Adolescents Circadian Rhythm Sleep Disorders, Non-24 Hour Sleep-Wake Disorder, Autism Spectrum Disorder | Phase 1 | 2016-10-04 |
| Completed | A Proof of Concept Study to Evaluate the Effects of Tasimelteon and Placebo in Travelers With Jet Lag Disorder Jet Lag Disorder | Phase 2 | 2016-07-01 |
| Completed | Tradipitant in Treatment-resistant Pruritus Associated With Atopic Dermatitis Atopic Dermatitis | Phase 2 | 2016-01-19 |
| Recruiting | Development of Clinical Database of Individuals With Smith-Magenis Syndrome and Sleep Disturbances Sleep Disturbances in Smith-Magenis Syndrome | — | 2016-01-01 |
| Completed | Study to Assess the Effect of Multiple Doses of Tradipitant on CYP3A4 Using Midazolam as a Substrate in Health Healthy Volunteers | Phase 1 | 2015-11-01 |
| Completed | An Observational Study to Investigate the Effects of Rapid Transmeridian Travel Jet Lag Disorder | — | 2015-09-01 |
| Completed | Evaluating the Effects of Tasimelteon vs Placebo on Sleep Disturbances in SMS Smith-Magenis Syndrome, Circadian | Phase 2 / Phase 3 | 2015-09-01 |
| Unknown | Observational Study to Investigate the Melatonin and Cortisol Circadian Rhythms of Individuals With Smith-Mage Smith Magenis Syndrome | — | 2014-06-01 |
| Completed | Open Label Study to Assess the Absolute Bioavailability of Tasimelteon (HETLIOZ™) Non-24-Hour-Sleep-Wake Disorder | Phase 4 | 2014-05-01 |
| Completed | Proof of Concept of VLY-686 in Subjects With Treatment-Resistant Pruritus Associated With Atopic Dermatitis Treatment-resistant Pruritus Associated With Atopic Dermatitis | Phase 2 | 2013-12-10 |
| Completed | Study of Itch Control by VLY-686 in Healthy Volunteers After Intradermal Injections of Substance P Pruritus | Phase 1 | 2013-08-01 |
| Completed | Pharmacokinetics of Tasimelteon Alone and in Combination With a CYP3A4 Inhibitor, Ketoconazole, or a CYP3A4 In Healthy | Phase 1 | 2012-06-01 |
| Completed | Evaluation of the Pharmacodynamic and Pharmacokinetic Interactions of Tasimelteon and Ethanol Pharmacodyamics and Pharmacokinetics of Tasimelteon Alone and in Combination With Ethanol | Phase 1 | 2012-04-01 |
| Completed | Pharmacokinetics of Tasimelteon in Subjects With Renal Impairment and Matched Control Subjects With Relatively Renal Impairment | Phase 1 | 2012-02-01 |
| Completed | Pharmacokinetics of Tasimelteon Alone and in Combination With CYP1A2 Inhibitor, Fluvoxamine Healthy Volunteers | Phase 1 | 2012-02-01 |
| Completed | Effects of Smoking, Age and Body Size on Pharmacokinetics, Safety and Tolerability on Tasimelteon in Healthy S Healthy Volunteers | Phase 1 | 2011-11-01 |
| Completed | Tolerability and Pharmacokinetics of Iloperidone in Adolescent Patients Safety and Tolerability of Iloperidone | Phase 1 | 2011-10-01 |
| Completed | Tasimelteon for the Treatment of Non-24-hour Sleep-Wake Disorder (N24HSWD) in Blind Individuals With no Light Non-24-Hour Sleep-Wake Disorder | Phase 3 | 2011-10-01 |
| Completed | Melatonin Agonist Effects of Tasimelteon Versus Placebo in Patients With Major Depressive Disorder Major Depressive Disorder | Phase 2 / Phase 3 | 2011-09-01 |
| Completed | Withdrawal Study to Demonstrate the Maintenance Effect in the Treatment of Non-24-Hour Sleep-Wake Disorder Non-24-Hour Sleep-Wake Disorder | Phase 3 | 2011-09-01 |
| Completed | A Study to Assess the Effect Tasimelteon on the Cytochrome P450 3A4 and 2C8 Enzymes in Healthy Subjects Healthy Volunteers | Phase 1 | 2011-08-01 |
| Completed | Relapse Prevention Study in Patients With Schizophrenia Schizophrenia | Phase 3 | 2011-02-01 |
| Completed | Pharmacokinetics of Tasimelteon in Subjects With Mild or Moderate Hepatic Impairment Hepatic Impairment | Phase 1 | 2011-01-01 |
| Active Not Recruiting | Safety Study of Tasimelteon for Treatment of Non-24-Hour-Sleep-Wake Disorder in Blind Individuals With No Ligh Non 24 Hour Sleep Wake Disorder | Phase 3 | 2010-10-28 |
| Completed | Efficacy and Safety of Tasimelteon Compared With Placebo in Totally Blind Subjects With Non-24-Hour Sleep-Wake Non-24-Hour Sleep-Wake Disorder | Phase 3 | 2010-08-01 |
| Recruiting | Patient Registry of Blind Subjects With Sleep-related Problems Sleep-wake Disorder in Blind Individuals | — | 2010-04-01 |
| Completed | VEC-162 Study in Adult Patients With Primary Insomnia Primary Insomnia | Phase 3 | 2007-11-01 |
| Completed | VEC-162 Study in Healthy Adult Volunteers in a Model of Insomnia Insomnia | Phase 3 | 2006-02-01 |
| Completed | Efficacy and Safety of Iloperidone Compared With Placebo and Active Control in Subjects With Acute Schizophren Schizophrenia | Phase 3 | 2005-11-18 |
| Completed | Safety and Efficacy of VEC-162 on Circadian Rhythm in Healthy Adult Volunteers Circadian Rhythm Sleep Disorders | Phase 2 | 2004-07-01 |
| Available | Single-Patient Expanded Access Protocol for Tradipitant In A Single Patient With Gastroparesis Gastroparesis, Diabetic Gastroparesis | — | — |
| Completed | VSF-173 Study in Healthy Adult Volunteers for Treatment of Induced Excessive Sleepiness Excessive Somnolence | Phase 2 | — |