| Recruiting | A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BAL2420 in Healthy Adult Subject Healthy | Phase 1 | 2026-03-04 |
| Recruiting | A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Patients With Invasive Mold Inf Invasive Mold Infections | Phase 3 | 2025-08-26 |
| Completed | A Study of Fosmanogepix in Healthy Adult Chinese Subjects Healthy | Phase 1 | 2025-04-14 |
| Completed | A Study to Assess the Effect of Ceftobiprole on the PK of Pitavastatin and on Plasma Levels of Coproporphyrin Drug-drug Interaction Study | Phase 1 | 2025-01-17 |
| Recruiting | Safety and PK of Ceftibuten-ledaborbactam Etzadroxil Fixed-dose Combination Healthy Volunteer, Pharmacokinetics, Safety | Phase 1 | 2025-01-07 |
| Recruiting | A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia an Candidemia, Candidiasis, Invasive | Phase 3 | 2024-12-11 |
| Completed | Plasma and Intrapulmonary Pharmacokinetics of Ceftibuten and Ledaborbactam in Healthy Male and Female Particip Pharmacokinetics, Healthy Volunteers | Phase 1 | 2024-11-04 |
| Completed | Late-onset Sepsis in Term and Pre-term Neonates and Infants up to 3 Months of Age Neonatal Sepsis | Phase 3 | 2023-08-06 |
| Completed | A Clinical Trial of the Study Medicine (Called Fosmanogepix) in Participants With Varying Degrees of Hepatic F Hepatic Impairment | Phase 1 | 2022-10-31 |
| Completed | Ceftibuten/VNRX-7145 in Participants With Varying Degrees of Renal Function Pharmacokinetics | Phase 1 | 2022-10-12 |
| Completed | Food Effect on Ceftibuten/VNRX-7145 in Healthy Participants Pharmacokinetics | Phase 1 | 2022-09-13 |
| Completed | VNRX-7145 Drug-Drug Interaction in Healthy Adult Volunteers Healthy Subjects | Phase 1 | 2021-06-08 |
| Completed | A Bioequivalence Study of APX001 High-load and Low-load Tablets Invasive Fungal Infections | Phase 1 | 2021-03-02 |
| Terminated | Derazantinib Alone or in Combination With Paclitaxel, Ramucirumab or Atezolizumab in Gastric Adenocarcinoma Gastric Adenocarcinoma | Phase 1 / Phase 2 | 2020-10-06 |
| Completed | VNRX-5024 Safety and PK in Healthy Adult Volunteers Healthy Subjects | Phase 1 | 2020-07-27 |
| Completed | VNRX-7145 SAD/MAD Safety and PK in Healthy Adult Volunteers Healthy Volunteers | Phase 1 | 2020-01-20 |
| Terminated | Open-label Study of APX001 for Treatment of Patients With Invasive Mold Infections Caused by Aspergillus or Ra Invasive Fungal Infections | Phase 2 | 2020-01-04 |
| Completed | An Open-label Study of APX001 for Treatment of Patients With Candidemia/Invasive Candidiasis Caused by Candida Candidemia, Invasive Candidiases, Candida Infection | Phase 2 | 2019-12-13 |
| Completed | A Drug-Drug Interaction Study of CYP3A4 Inhibition and Pan-CYP Induction on APX001 Fungal Infection | Phase 1 | 2019-11-12 |
| Completed | Mass Balance and Pharmacokinetics Study of Derazantinib in Healthy Male Subjects Healthy Volunteers | Phase 1 | 2019-08-08 |
| Completed | Derazantinib and Atezolizumab in Patients With Urothelial Cancer Urothelial Carcinoma | Phase 1 / Phase 2 | 2019-08-02 |
| Completed | An Efficacy and Safety Study of APX001 in Non-Neutropenic Patients With Candidemia Candidemia | Phase 2 | 2018-10-03 |
| Completed | Ceftobiprole in the Treatment of Patients With Staphylococcus Aureus Bacteremia Staphylococcus Aureus Bacteremia | Phase 3 | 2018-08-26 |
| Completed | A Study to Assess the Mass Balance Recovery and Metabolite Profile & Identification of [14C]-APX001 in Healthy Fungal Infection | Phase 1 | 2018-08-17 |
| Completed | Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections Acute Bacterial Skin and Skin Structure Infections | Phase 3 | 2018-02-19 |
| Terminated | Microtubule-Targeted Agent BAL101553 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblast Glioblastoma, MGMT-Unmethylated Glioblastoma | Phase 1 | 2017-12-15 |
| Completed | Ceftobiprole in the Treatment of Pediatric Patients With Pneumonia Community-acquired Pneumonia (CAP), Hospital-acquired Pneumonia (HAP) | Phase 3 | 2017-11-27 |
| Completed | Safety and Pharmacokinetics of Intravenous and Oral APX001 in Patients With Acute Myeloid Leukemia (AML) and N Acute Myeloid Leukemia | Phase 1 | 2017-11-27 |
| Completed | Derazantinib in Subjects With FGFR2 Gene Fusion-, Mutation- or Amplification- Positive Inoperable or Advanced Intrahepatic Cholangiocarcinoma, Combined Hepatocellular and Cholangiocarcinoma | Phase 2 | 2017-09-28 |
| Terminated | Pharmacokinetics and Safety of Ceftobiprole in Neonates and Infants up to 3 Months Treated With Systemic Antib Bacterial Infections | Phase 1 | 2016-11-22 |
| Completed | Safety, Pharmacokinetics, Bioavailability, Food Effect, Drug-Drug Interaction Study of APX001 Administered Ora Fungal Infection | Phase 1 | 2016-10-31 |
| Completed | Phase 1/2a Study of BAL101553 as 48-hour Infusions in Patients With Advanced Solid Tumors or Recurrent Gliobla Neoplasms | Phase 1 / Phase 2 | 2016-08-24 |
| Completed | Study to Assess Safety, Tolerability and Pharmacokinetics of APX001 Administered by Intravenous Infusion to He Fungal Infection | Phase 1 | 2016-05-24 |
| Completed | Phase 1/2a Study of Oral BAL101553 in Adult Patients With Solid Tumors or Glioblastoma or High-grade Glioma Neoplasms | Phase 1 / Phase 2 | 2015-05-20 |
| Completed | Phase 1/2 Study of Derazantinib (ARQ 087) in Adult Subjects With Advanced Solid Tumors With FGFR Genetic Alter Solid Tumor | Phase 1 / Phase 2 | 2012-12-10 |
| Completed | An Open-Label Study of Intravenous BAL101553 in Adult Patients With Solid Tumors Solid Organ Tumors | Phase 1 / Phase 2 | 2011-06-01 |
| Completed | Effect of Ceftobiprole on Human Intestinal Microflora Antimicrobial Agent, Cephalosporins, Drug Resistance | Phase 1 | 2009-04-01 |
| Completed | Pharmacokinetic Study of the Penetration of Ceftobiprole in the Bone Total Hip Replacement Surgery | Phase 1 | 2009-04-01 |
| Completed | Open Label Study of Ceftobiprole to Evaluate Pharmacokinetics in Adults Hospitalized in the ICU ICU | Phase 1 | 2008-11-01 |
| Terminated | Open Label Pharmacokinetic in Adult Patients With Ventilator-Associated Pneumonia Ventilator Associated Pneumonia | Phase 1 | 2008-10-01 |
| Terminated | A Study of Ceftobiprole in Patients With Fever and Neutropenia. Fever, Neutropenia, Gram-positive Bacterial Infections | Phase 3 | 2007-10-01 |
| Completed | A Single-Dose Pharmacokinetics and Safety Study of Ceftobiprole in Pediatric Patients =3 Months to <18 Years o Staphylococcal Skin Infections, Streptococcal Infections | Phase 1 | 2007-08-01 |
| Completed | A Study Evaluating the Pharmacokinetics of Ceftobiprole When Taken by Obese Patients Obesity, Staphylococcal Skin Infections, Streptococcal Infections | Phase 1 | 2007-08-01 |
| Completed | Evaluation of Penetration of Ceftobiprole Into Soft Tissue Determined by Microdialysis in Healthy Volunteers Staphylococcal Skin Infections, Streptococcal Infections | Phase 1 | 2007-06-01 |
| Completed | Pharmacokinetic Study,Ceftobiprole,Healthy Volunteers,Healthy Patients With End Stage Renal Disease Staphylococcal Skin Infections, Streptococcal Infections | Phase 1 | 2007-05-01 |
| Completed | Alitretinoin in the Treatment of Chronic Hand Eczema Eczema | Phase 3 | 2007-05-01 |
| Completed | Ceftobiprole in the Treatment of Patients With Community-Acquired Pneumonia Pneumonia | Phase 3 | 2006-06-01 |
| Completed | Safety, Efficacy and Pharmacokinetics of an Antifungal in Patients Undergoing Chemotherapy Acute Myeloid Leukemia | Phase 2 / Phase 3 | 2006-05-01 |
| Completed | Safety and Efficacy of a Retinoid for the Treatment of Severe Chronic Hand Dermatitis Hand Dermatoses | Phase 3 | 2006-04-01 |
| Completed | Ceftobiprole in Hospital Acquired Pneumonia Pneumonia | Phase 3 | 2005-11-01 |
| Completed | Ceftobiprole in the Treatment of Resistant Staphylococcus Aureus Skin and Skin Structure Infections Skin Diseases, Infectious, Skin Diseases, Bacterial, Staphylococcal Skin Infections | Phase 3 | 2005-09-01 |
| Completed | Ceftobiprole in Hospital Acquired Pneumonia Pneumonia | Phase 3 | 2005-04-01 |
| Completed | Follow-up Efficacy and Safety of Alitretinoin in Severe Chronic Hand Dermatitis Hand Dermatoses | Phase 3 | 2005-03-01 |
| Completed | Efficacy and Safety of a Retinoid for the Treatment of Severe Chronic Hand Dermatitis Hand Dermatoses | Phase 3 | 2004-12-01 |
| Completed | Ceftobiprole in the Treatment of Resistant Staphylococcus Aureus Skin and Skin Structure Infections Skin Diseases, Infectious, Skin Diseases, Bacterial, Staphylococcal Skin Infections | Phase 3 | 2004-10-01 |
| No Longer Available | Expanded Access Use of Derazantinib for Advanced Intrahepatic Cholangiocarcinoma (iCCA) With FGFR Genomic Alte Intrahepatic Cholangiocarcinoma | — | — |
| Available | Expanded Access to Fosmanogepix for Patients With Serious or Life-threatening Invasive Fungal Infections Invasive Fungal Infections | — | — |
| Withdrawn | Ceftobiprole in the Treatment of Hospitalized Patients With Staphylococcus Aureus Bacteremia Bacteremia | Phase 2 | — |