| Terminated | A Study of Oral Decitabine/Cedazuridine in Combination With Magrolimab in Participants With Intermediate- to V Myelodysplastic Syndromes | Phase 2 | 2023-06-27 |
| Completed | Thorough QT Assessment of Cedazuridine in Healthy Subjects Healthy Volunteers | Phase 1 | 2021-07-01 |
| Terminated | A Study of TAS1553 in Subjects With Relapsed or Refractory Acute Myeloid Leukemia (AML) and Other Myeloid Neop Acute Myeloid Leukemia, Myeloproliferative Neoplasm, Myelodysplastic/Myeloproliferative Neoplasm | Phase 1 | 2020-12-21 |
| Completed | A Phase 1 Study to Evaluate the Effect of Food on Pharmacokinetics of ASTX029 Healthy Volunteers | Phase 1 | 2020-07-23 |
| Completed | Effect of Food on the Pharmacokinetics of ASTX660 in Healthy Volunteers Healthy Volunteer | Phase 1 | 2020-07-20 |
| Terminated | A Study of ASTX660 as a Single Agent and in Combination With ASTX727 in Subjects With Relapsed/Refractory Acut Acute Myeloid Leukemia | Phase 1 | 2020-06-12 |
| Completed | A Study to Investigate the Effect of CYP3A4 Inhibition on the Single Dose Pharmacokinetics of ASTX660 and the Healthy Volunteer | Phase 1 | 2020-05-20 |
| Completed | Effect of Food on Blood Levels of ASTX727 Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, Acute Myeloid Leukemia | Phase 1 | 2018-11-08 |
| Terminated | Guadecitabine Extension Study Acute Myeloid Leukemia, Myeloid Dysplastic Syndrome | Phase 2 | 2018-07-18 |
| Completed | Study of ASTX727 vs IV Decitabine in Participants With MDS, CMML, and AML Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, Acute Myeloid Leukemia | Phase 3 | 2018-02-15 |
| Completed | Phase 3 Randomized, Open-Label Study of Guadecitabine vs Treatment Choice in Previously Treated Acute Myeloid Acute Myeloid Leukemia | Phase 3 | 2017-03-16 |
| Completed | Guadecitabine (SGI-110) vs Treatment Choice in Adults With MDS or CMML Previously Treated With HMAs Myelodysplastic Syndromes, Leukemia, Myelomonocytic, Chronic | Phase 3 | 2017-01-13 |
| Completed | SGI-110 in Adults With Untreated Acute Myeloid Leukemia (AML), Not Considered Candidates for Intensive Remissi Leukemia, Myeloid, Acute | Phase 3 | 2015-03-19 |
| Completed | Pharmacokinetic Guided Dose Escalation and Dose Confirmation With Oral Decitabine and Oral Cytidine Deaminase Myelodysplastic Syndrome, MDS | Phase 1 / Phase 2 | 2014-10-28 |
| Completed | SGI-110 in the Treatment of Advanced Hepatocellular Carcinoma (HCC) Hepatocellular Carcinoma | Phase 2 | 2012-12-01 |
| Completed | A Study of AT13387 in Patients With Non-Small Cell Lung Cancer (NSCLC) Alone and in Combination With Crizotini Non-small Cell Lung Cancer(NSCLC) | Phase 1 / Phase 2 | 2012-10-01 |
| Completed | A Study of HSP90 Inhibitor AT13387 Alone or in Combination With Abiraterone Acetate Prostate Cancer | Phase 1 / Phase 2 | 2012-09-01 |
| Completed | SGI-110 in Combination With Carboplatin in Ovarian Cancer Ovarian Cancer | Phase 2 | 2012-09-01 |
| Completed | A Phase 2, Open-Label Study of Amuvatinib in Combination With Platinum-Etoposide Chemotherapy in Small Cell Lu Small Cell Lung Carcinoma | Phase 2 | 2011-05-01 |
| Completed | A Study to Investigate the Safety and Efficacy of AT13387, Alone or in Combination With Imatinib, in Patients Gastrointestinal Stromal Tumor (GIST) | Phase 2 | 2011-03-01 |
| Completed | SGI-110 in Participants With Myelodysplastic Syndromes (MDS) or Acute Myelogenous Leukemia (AML) MDS, CMML, AML | Phase 1 / Phase 2 | 2011-01-04 |
| Completed | Effect of AT7519M Alone and AT7519M Plus Bortezomib in Patients With Previously Treated Multiple Myeloma Multiple Myeloma | Phase 1 / Phase 2 | 2010-11-01 |
| Withdrawn | Study of SGI-1776, a PIM Kinase Inhibitor, in Subjects With Relapsed/Refractory Leukemias Relapsed/Refractory Leukemias | Phase 1 | 2010-10-01 |
| Terminated | Safety of SGI-1776, A PIM Kinase Inhibitor in Refractory Prostate Cancer and Relapsed/Refractory Non Hodgkin's Prostate Cancer, Non-Hodgkins Lymphoma | Phase 1 | 2009-02-01 |
| Completed | Study to Assess the Safety of Escalating Doses of AT13387 in Patients With Metastatic Solid Tumors Metastatic Solid Tumors | Phase 1 | 2008-05-01 |
| Completed | Safety of MP470 in Combination With Standard-of-Care Chemotherapy Regimens to Treat Solid Tumors Malignant Disease | Phase 1 | 2007-11-01 |
| Completed | Safety Study to Determine the Maximum Tolerated Dose, Pharmacokinetics and Pharmacodynamics of Oral MP470, a M Solid Tumors | Phase 1 | 2007-05-01 |
| Terminated | MP470 in Treating Patients With Unresectable or Metastatic Solid Tumor or Lymphoma Lymphoma, Unspecified Adult Solid Tumor, Protocol Specific | N/A | 2007-05-01 |
| Terminated | Study to Assess the Safety of Escalating Doses of AT9283, in Patients With Leukemias Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myeloid Leukemia | Phase 1 / Phase 2 | 2006-09-01 |
| Terminated | Orathecin + Gemcitabine Versus Placebo + Gemcitabine in Chemonaive Non-Resectable Pancreatic Cancer Pancreatic Cancer | Phase 2 / Phase 3 | 2005-02-01 |
| Completed | Phase II Trial of Decitabine in Patients With Chronic Myelogenous Leukemia Blast Phase Who Are Refractory to I Chronic Myelogenous Leukemia | Phase 2 | 2002-07-01 |
| Completed | Phase II Trial of Decitabine in Patients With Chronic Myelogenous Leukemia Accelerated Phase Who Are Refractor Chronic Myelogenous Leukemia | Phase 2 | 2002-07-01 |
| Completed | Phase II Trial of Decitabine in Patients With Chronic Myelogenous Leukemia Chronic Phase Who Are Refractory to Chronic Myelogenous Leukemia | Phase 2 | 2002-07-01 |
| Terminated | Dose-finding Study Using Pentostatin for Injection in the Treatment of Steroid-refractory aGvHD Acute Graft Versus Host Disease | Phase 1 / Phase 2 | 2002-01-30 |
| Completed | Study of Rubitecan in Cancer Patients With Renal or Hepatic Dysfunction Tumors | Phase 1 | 2001-08-01 |
| Completed | Decitabine Versus Supportive Care in Adults With Advanced-stage MDS Myelodysplastic Syndrome | Phase 3 | 2001-04-01 |
| Unknown | Nitrocamptothecin in Treating Patients With Locally Advanced or Metastatic Stomach Cancer That Cannot Be Remov Esophageal Cancer, Gastric Cancer | Phase 2 | 2000-04-01 |
| Unknown | Nitrocamptothecin in Treating Patients With Advanced or Recurrent Colorectal Cancer Colorectal Cancer | Phase 2 | 1999-09-01 |
| Completed | Nitrocamptothecin in Treating Patients With Locally Recurrent or Metastatic Breast Cancer Breast Cancer | Phase 2 | 1999-09-01 |
| Completed | Nitrocamptothecin in Treating Patients With Soft Tissue Sarcomas Gastrointestinal Stromal Tumor, Sarcoma, Small Intestine Cancer | Phase 2 | 1999-06-01 |
| Completed | Nitrocamptothecin in Treating Patients With Recurrent Non-small Cell Lung Cancer Lung Cancer | Phase 2 | 1999-05-01 |
| Unknown | Nitrocamptothecin Compared With Other Chemotherapy in Treating Patients With Recurrent or Refractory Cancer of Pancreatic Cancer | Phase 3 | 1999-03-01 |
| Completed | Nitrocamptothecin in Treating Patients With Metastatic Melanoma Melanoma (Skin) | Phase 2 | 1999-01-01 |
| Unknown | Nitrocamptothecin or Fluorouracil in Treating Patients With Recurrent or Refractory Pancreatic Cancer Pancreatic Cancer | Phase 3 | 1998-11-01 |
| Unknown | Nitrocamptothecin Compared With Gemcitabine in Treating Patients With Unresectable Locally Advanced or Metasta Pancreatic Cancer | Phase 3 | 1998-11-01 |