| Not Yet Recruiting | Design and Rationale of the COLT Study NCT07432529 | Azienda Sanitaria Locale ASL 6, Livorno | Phase 3 |
| Recruiting | Non-healing Venous Leg Ulcers Treated With Standard Care With or Without BR-AC NCT06811909 | BioStem Technologies | N/A |
| Completed | Digital Supported Compression Bandaging in Patients With Chronic Edema in the Lower Limbs NCT06438133 | Carsten Bogh Juhl | — |
| Recruiting | The ROle of Compression StocKings in Heart Failure Patients NCT06350695 | University of Maryland, Baltimore | N/A |
| Terminated | PICO Venous Leg Ulcers (VLU) Reimbursement Study NCT06510777 | Smith & Nephew, Inc. | N/A |
| Completed | Investigation of the Transmission Pathways of Reflux in Patients With Chronic Venous Insufficiency NCT06369207 | Golestan University of Medical sciences | — |
| Unknown | Comparison of Zero- and Two-centimeter Distance From Sapheno-femoral Junction in Laser Ablation of Varicose Ve NCT05707169 | Mansoura University | N/A |
| Completed | A Clinical Study to Evaluate the Effectiveness of a Novel Portable Non-Pneumatic Active Compression Device vs. NCT05507346 | Koya Medical, Inc. | N/A |
| Unknown | Outcomes of Sclerotherapy of the Ulcer Bed Compared to a Combination of Ablation and Injections NCT05633277 | ProMedica Health System | N/A |
| Recruiting | Prospective Cohort Study for Varicose Veins Incidence and Natural Course NCT04546750 | Russian Phlebological Association | — |
| Unknown | Efficacy and Safety of Endovenous Microwave Ablations for Treatment of Varicose Veins in Singapore NCT04524793 | Singapore General Hospital | N/A |
| Unknown | Inspiratory Muscle Training Versus Calf Muscle on Venous Function NCT04215133 | Istanbul University - Cerrahpasa | N/A |
| Completed | Retrospective Review of Saphenous Vein Incompetence: Venaseal Versus Endovenous Thermal Ablation NCT04006184 | Lake Washington Vascular | — |
| Completed | Exercise Training in Venous Insufficiency NCT03755180 | Istanbul University - Cerrahpasa | N/A |
| Unknown | The Effectiveness of Trans-catheter Foam Sclerotherapy of Pelvic and Atypical Lower Limb Varicosities NCT03652025 | Assiut University | N/A |
| Completed | The Effect of Manual Lymphatic Drainage NCT04461132 | Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey | N/A |
| Active Not Recruiting | Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy (The C-TRACT Trial) NCT03250247 | Washington University School of Medicine | N/A |
| Terminated | A Study Evaluating ClariVein With a Sclerosing Agent for the Treatment of Venous Insufficiency NCT03311269 | Vascular Insights, LLC | Phase 2 |
| Completed | The Effect of Training on Hemodynamic Factors in Ballet Dancer NCT04469361 | Marmara University | — |
| Completed | Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in Symptomatic Chronic Venous Insu NCT03471910 | Fundação Educacional Serra dos Órgãos | Phase 4 |
| Terminated | Amniotic Membrane Allograft Application in the Management of Venous Leg Ulcerations NCT02929056 | Prisma Health-Upstate | Phase 4 |
| Completed | Effectiveness of a Pressure Indicator Guided and a Conventional Bandaging in Treatment of Venous Leg Ulcer NCT02729688 | Mahidol University | N/A |
| Completed | Evaluation of Electrocardiographic Guidance in Accurate Peripherally Inserted Central Catheter Placement in Ch NCT02324504 | Boston Children's Hospital | N/A |
| Completed | VEINEX : Venous Investigations During Exercise NCT02689557 | University Hospital, Angers | N/A |
| Completed | DESIVI: Dosing of Electrical Stimulation in Venous Insufficiency NCT03850496 | Imperial College London | N/A |
| Completed | Copper Impact on Venous Insufficiency and Lipodermatosclerosis NCT03283800 | Croydon Health Services NHS Trust | N/A |
| Completed | Cooling Leg and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence NCT02626156 | Medical University of South Carolina | Phase 2 |
| Completed | Venavine Intensive® in the Treatment of Symptoms Associated With Chronic Venous Insufficiency NCT02483962 | University of Johannesburg | Phase 2 |
| Completed | Evaluation of the Safety of Compressive Socks to Treat Venous Insufficiency in Patients With Peripheral Arteri NCT02431819 | Centre Hospitalier Universitaire de Saint Etienne | N/A |
| Completed | The Efficacy of Venavine Intensive® on the Quality of Life in Females With Chronic Venous Insufficiency NCT02498327 | University of Johannesburg | Phase 2 |
| Completed | Evaluation of a Dual Action Pneumatic Compression System: Tolerance and Comfort in Patients With Venous Leg Ul NCT02395302 | Tactile Medical | N/A |
| Active Not Recruiting | Lower Limb Venous Insufficiency and the Effect of Radiofrequency Treatment Versus Open Surgery NCT02397226 | University Hospital, Linkoeping | N/A |
| Withdrawn | Does Minimal Post-operative Compression Affect the Outcome for Endovenous Ablation in Treating Varicose Vein P NCT02241707 | NYC Surgical Associates | — |
| Withdrawn | Treatment of Chronic Wound Biofilms NCT01646502 | University of British Columbia | N/A |
| Completed | The Effects of Compression Stockings on Pressure Parameters in Patients With Chronic Venous Insufficiency NCT01558024 | Centre Hospitalier Universitaire de Nīmes | N/A |
| Completed | Transient Elastography DEdicated to Cosmetology And Dermatology (TEDECAD) NCT02061254 | University Hospital, Tours | N/A |
| Completed | REVITIVE for the Treatment of Patients With Venous Insufficiency NCT02114307 | Imperial College London | N/A |
| Completed | Radiofrequency Ablation vs Conventional Surgery for Superficial Venous Insufficiency NCT02588911 | Nelson Wolosker | N/A |
| Completed | Venous Insufficiency and Neuromuscular Stimulation NCT02137499 | Imperial College London | N/A |
| Completed | SocknLeg - a User Friendly Medical Compression Study of a Modified Application of a Medical Device NCT02621632 | University of Zurich | Phase 4 |
| Withdrawn | Compliance of Compression Therapy in Healed Venous Ulcerations NCT01680809 | University Hospitals Cleveland Medical Center | N/A |
| Completed | BRAVE-DREAMS (BRAin VEnous DRainage Exploited Against Multiple Sclerosis) NCT01371760 | S. Anna Hospital | N/A |
| Completed | Effects of Non Contact Low Frequency Ultrasound in Healing Venous Leg Ulcers NCT01549860 | Celleration, Inc. | N/A |
| Completed | Preventing the Development of Venous Insufficiency in Pregnant Women Through Use of Compression Stockings NCT01793194 | Johns Hopkins University | N/A |
| Completed | The Party Balloon Assisted Valsalva in Diagnosis of Superficial Venous Valvular Reflux of Lower Limb NCT02051439 | Mahidol University | N/A |
| Completed | Cooling Lower Leg Skin to Prevent Venous Leg Ulcers in Patients With Poor Vein Circulation NCT01509599 | Medical University of South Carolina | Phase 1 / Phase 2 |
| Unknown | Safety and Efficacy of the External Synchronized Vein Valve (ESVV) in Treatment of Chronic Venous Insufficienc NCT01346553 | GB-Veintech | N/A |
| Completed | Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia Later in Life NCT01367977 | Genetic Disease Investigators | — |
| Completed | Feasibility, Efficacy, and Safety of Venous Ulcer Treatment Using a Hand Plasma Generator (PlasmaDerm) Chronis NCT01415622 | Cinogy GmbH | N/A |
| Unknown | Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treat NCT01110512 | Azidus Brasil | Phase 3 |
| Withdrawn | Comparison Study for Safety and Efficacy of Two Devices for the Treatment of the Great Saphenous Vein NCT01173419 | Angiodynamics, Inc. | N/A |
| Unknown | Endoluminale Obliteration Der Stammvene Mit Dem 1470nm Laser Versus VNUS Closure Fast NCT01972633 | Ludwig Boltzmann Institute for Operative Laparoscopy | Phase 1 / Phase 2 |
| Terminated | RFS (Radiofrequency Stylet) - Radiofrequency Perforator Vein Treatment Study NCT01079598 | Medtronic Endovascular | N/A |
| Completed | Non-Invasive Management of Chronic Venous Insufficiency NCT00950378 | University of Utah | — |
| Completed | Assess the Efficacy and Tolerability of Antistax Film-coated Tablets in Patients With Chronic Venous Insuffici NCT00855179 | Boehringer Ingelheim | Phase 3 |
| Completed | Pilot Study for VeinoPlus to Improve Symptoms of Postthrombotic Syndrome (PTS) NCT00858130 | University of North Carolina, Chapel Hill | N/A |
| Completed | THERMES ET VEINES: Spa for Prevention of Leg Ulcers NCT00838500 | Association Francaise pour la Recherche Thermale | Phase 3 |
| Completed | Taliderm Dressing for Venous Ulcers NCT00720239 | Medical University of South Carolina | EARLY_Phase 1 |
| Completed | Comparison of Treatments in Venous Insufficiency NCT01298908 | Helsinki University Central Hospital | N/A |
| Completed | Safety and Efficacy of Endovenous Laser Ablation for the Resolution of Incompetent Perforator Veins NCT00565604 | Vascular Solutions LLC | N/A |
| Completed | Feasibility Study of Cryotherapy for Chronic Venous Disorders NCT00617825 | Medical University of South Carolina | N/A |
| Completed | Obtaining and Storing Blood Samples and Debridement Samples for Wound Related Research NCT00762697 | Southwest Regional Wound Care Center | — |
| Completed | Evaluating the Relationship Between Blood Clotting Disorders, Inflammation, and Obesity in Individuals With Ve NCT00395265 | University of Vermont | — |
| Completed | Evaluation of DermStream(tm) - an Irrigation Product for Chronic Wound Management NCT00310752 | EnzySurge | Phase 1 / Phase 2 |
| Completed | Efficacy and Tolerability CVI (A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial (CVI NCT00292435 | Boehringer Ingelheim | Phase 3 |
| Unknown | Endovenous Laser Therapy (EVLT) for Sapheno-Popliteal Incompetence and Short Saphenous Vein (SSV) Reflux: A RC NCT00841178 | Hull University Teaching Hospitals NHS Trust | N/A |
| Unknown | The Evaluation of OrCel for the Treatment of Venous Ulcers NCT00270972 | Ortec International | N/A |
| Completed | Compression Device Safety Study NCT00732823 | ConvaTec Inc. | Phase 2 |
| Completed | The Influence of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Disease NCT00196443 | University Medicine Greifswald | Phase 2 / Phase 3 |
| Completed | Efficacy and Safety of the Use of Venocur Triplex® in Patients With Chronic Venous Insufficiency NCT00835822 | Abbott | Phase 4 |
| Completed | Epidemiology of Thromboembolism Disease: A Cohort Study NCT00670540 | University Hospital, Grenoble | — |
| Completed | Compression Therapy Versus Surgery in the Treatment of Superficial Venous Reflux NCT01701661 | Helsinki University Central Hospital | N/A |
| Completed | Clinical Study of BNS003 on Swelling in Legs Due to Venous Reflux NCT02211898 | Boehringer Ingelheim | Phase 3 |
| Completed | Efficacy and Tolerability of Antistax® in Male and Female Patients Suffering From Chronic Venous Insufficiency NCT02191254 | Boehringer Ingelheim | Phase 3 |
| Completed | A New Method of Surgically Treating Varicose Veins and Venous Ulcers - a Study to Assess Clinical and Economic NCT00759434 | Hull University Teaching Hospitals NHS Trust | N/A |
| Completed | ESGVS: Sclerotherapy With Lauromacrogol NCT00348764 | University Hospital, Grenoble | Phase 3 |
| Completed | Efficacy of Antistax® in Improving Microcirculation of the Skin in the Leg in Patients Suffering From Chronic NCT02191163 | Boehringer Ingelheim | Phase 2 |
| Completed | Tolerability of Antistax® in Patients Suffering From Chronic Venous Insufficiency (CVI) NCT02184234 | Boehringer Ingelheim | Phase 4 |
| Completed | Physical Conditioning in Management of Chronic Venous Insufficiency NCT00013273 | US Department of Veterans Affairs | Phase 2 |
| Completed | Antistax® in Patients With Chronic Venous Insufficiency NCT02191280 | Boehringer Ingelheim | Phase 2 |
| Completed | The Fate Of Calf Perforators After Endovenous Laser Ablation Of Saphenous Veins NCT01458795 | Baskent University | Phase 4 |