| Not Yet Recruiting | Vaginal Estradiol vs Moisturizer to Improve Postmenopausal Vaginal Aging Symptoms and the Microbiome in Women NCT07526948 | Albert Einstein College of Medicine | Phase 4 |
| Not Yet Recruiting | Testing Laser Therapy for Treatment of Vaginal Dryness in Survivors of Breast Cancer, The Revitalize Trial NCT05379153 | Alliance for Clinical Trials in Oncology | Phase 3 |
| Not Yet Recruiting | Compare Vaginal Estrogen and Platelet-rich Plasma Over Women With Genitourinary Syndrome of Menopause NCT05483634 | Mackay Memorial Hospital | — |
| Recruiting | ASSIST-VLA: Assessment of Symptom-Specific Improvement in Diagnosed Vaginal Atrophy Following Laser Therapy NCT07346287 | Stratpharma AG | Phase 4 |
| Not Yet Recruiting | Hydration and Acceptability of the Genital and Skin Mucosa of a Vaginal Moisturizer in Menopausal Women NCT06564883 | Biolab Sanus Farmaceutica | Phase 3 |
| Recruiting | Postpartum Vaginal Estrogen for Breastfeeding Patients NCT05457972 | University Hospitals Cleveland Medical Center | Phase 4 |
| Not Yet Recruiting | The Efficacy of Topical Vaginal Oxytocin Gel in Postmenopausal Women With Vulvovaginal Atrophy NCT06514586 | Oxagon | Phase 3 |
| Completed | Perceived Effectiveness of the Vaginal Moisturizer Investigational Product Under Normal Conditions of Use. NCT06353945 | Herbarium Laboratorio Botanico Ltda | N/A |
| Active Not Recruiting | Effect of Local Estriol Treatment Before Vaginal Repair Surgery NCT06391372 | Hatice Tukenmez Kurnaz | Phase 3 |
| Active Not Recruiting | PRP Injections for Genitourinary Syndrome of Menopause NCT06028009 | Medstar Health Research Institute | N/A |
| Recruiting | VALOR: Vaginal Atrophy & Long-term Observation of Recovery NCT05953090 | Stratpharma AG | N/A |
| Completed | Elastographic Improvement of Vaginal Atrophy Treated by Erbium Yag Laser NCT06000202 | Istanbul University - Cerrahpasa | N/A |
| Completed | Clinical Performance and Safety of the VITA AV Clinical System NCT06207227 | AVeta Medical | N/A |
| Terminated | Vaginal Estradiol Use in Pessary Care NCT05458375 | University of South Florida | EARLY_Phase 1 |
| Terminated | Effects of Vaginal Oxytocin Gel on Vaginal Cytologic Parameters in Postmenopausal Woman NCT05627791 | Department of Medical Services Ministry of Public Health of Thailand | Phase 2 / Phase 3 |
| Withdrawn | Laser Treatment of Genito-urinary Syndrome in Women NCT03238053 | Herning Hospital | N/A |
| Completed | Low-level Laser Therapy for Genitourinary Syndromes and Stress Urinary Incontinence NCT06136975 | National Taiwan University Hospital | — |
| Recruiting | Clinical and Molecular Study to Evaluate the Effect of the Pixel CO2 Laser (FemiLiftTM) for the Treatment of V NCT07024667 | Hillel Yaffe Medical Center | N/A |
| Completed | Clinical Trial of "Magic Gyno" Laser Device NCT05463081 | MeLSyTech, Ltd | N/A |
| Recruiting | Treatment of Vaginal Atrophy With Low Intensity Nanosecond Neodymium Laser NCT05335317 | MeLSyTech, Ltd | N/A |
| Completed | Real-world Evidence Study on the Performance and Safety of Halova Ovules NCT05654610 | Perfect Care Distribution | — |
| Completed | Investigation of Efficacy and Tolerability of WO 2707, a MoistCream Cremolum, in Postmenopausal Women Sufferin NCT05211505 | Dr. August Wolff GmbH & Co. KG Arzneimittel | Phase 4 |
| Completed | Vulvovaginal Atrophy Correction Using Neodymium Laser NCT04735549 | MeLSyTech, Ltd | N/A |
| Completed | Clinical Evaluation of Fractional Bi-Polar Radio-Frequency for Symptoms of Vulvovaginal Atrophy NCT05398172 | InMode MD Ltd. | N/A |
| Terminated | Vaginal Dehydroepiandrosterone (DHEA) in Postmenopausal Breast Cancer Survivors on Aromatase Inhibitors NCT04493333 | University of Arkansas | Phase 2 |
| Withdrawn | A Randomized Controlled Phase 2 Study to Determine Lowest Efficacious Dose of Ovestin in Vulvar and Vaginal At NCT04159493 | Aspen USA Inc | Phase 2 |
| Completed | Non-Interventional Multicentre Post-market Study of Ectoin® Vaginal Gel for Symptomatic Treatment of Vaginal A NCT04910906 | Bitop AG | — |
| Recruiting | Prevention of Recurrent UTI Using Vaginal Testosterone Versus Placebo Placebo NCT04807894 | Maimonides Medical Center | Phase 4 |
| Completed | Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial NCT04079218 | Kerry Murphy | Phase 4 |
| Completed | Histological Modifications of Postmenopausal Vaginal Mucosa After Repeated Carbon Dioxide (CO2) Laser Treatmen NCT04868812 | IRCCS San Raffaele | N/A |
| Completed | Evaluation of the Efficacy and Safety of the Dermal Filler for Female Intimate Area Hydration and Atrophy of t NCT04659668 | Mesoestetic Pharma Group S.L. | N/A |
| Active Not Recruiting | LASER and Radiofrequency for Treatment of Vaginal Vulvar Atrophy (VVA) in Women Treated for Breast Cancer (EPM NCT04081805 | Federal University of São Paulo | N/A |
| Completed | Clinical Study to Compare the Efficacy of Erbium-Yag Laser or CO2RE Intimate Laser With Sham (COER) NCT04039555 | Instituto Palacios | N/A |
| Completed | A Clinical Clinical Observation of CO2 Fractional Laser in Female Vaginal Repair NCT04492176 | Xijing Hospital | N/A |
| Completed | Investigation of Microbiomes of Postmenopausal Women Looking for Outcomes and Response to Estrogen Therapy NCT03996603 | University of Alabama at Birmingham | Phase 4 |
| Completed | Evaluation of VagiVital® for Treatment of Vaginal Atrophy NCT03998722 | PepTonic Medical AB | N/A |
| Unknown | Effect of Hybrid Laser 10600+1540 nm on GSM NCT03956563 | Quanta System, S.p.A. | N/A |
| Unknown | Effect of Laser Therapy on Vaginal Tissue NCT05898191 | Institute for the Care of Mother and Child, Prague, Czech Republic | N/A |
| Unknown | Vaginal Laser Therapy in Breast Cancer Survivors NCT03738605 | National and Kapodistrian University of Athens | N/A |
| Completed | Exploratory Study on Two Different Doses of VML-0001 on the Effects on Vaginal pH in Healthy Post-Menopausal W NCT03770065 | Viramal Limited | — |
| Completed | Comparative Study: Vaginal Promestriene Use, Fractional CO2 LASER and Radiofrequency in the Vaginal Atrophy Tr NCT04717245 | University of Sao Paulo General Hospital | N/A |
| Completed | Vaginal Estrogen on Postpartum Atrophy, Perineal Pain, and Sexual Function NCT03493126 | Ohio State University | Phase 4 |
| Suspended | A Prospective Trial to Assess Breast Cancer Survivors and Vaginal Atrophy Treatment Outcomes NCT03547089 | W. Grant Stevens, MD | N/A |
| Completed | Radiofrequency and Hybrid Fractional Laser for Vaginal Rejuvenation NCT03316950 | University of Texas Southwestern Medical Center | N/A |
| Completed | CO2 Laser in the Treatment of the GSM - (Genitourinary Syndrome of Menopause) Genitourinary Syndrome of Menopa NCT03939078 | Universidade Federal Fluminense | — |
| Unknown | Evaluation of Efficacy and Safety of Votiva for Vaginal Rejuvenation NCT03520426 | Walden, Jennifer L., M.D.,P.L.L.C. | N/A |
| Unknown | Vaginal CO2 Laser and the Genitourinary Syndrome of Menopause NCT03754205 | National and Kapodistrian University of Athens | N/A |
| Completed | Fractional / Pixel CO2 Laser Treatment of Vulvar Atrophy and Lichen Sclerosus NCT03063684 | Hadassah Medical Organization | N/A |
| Completed | Hybrid Fractional Laser for Symptoms of Genitourinary Syndrome of Menopause NCT03178825 | Sciton | N/A |
| Completed | Study Evaluating the Efficacy and Safety of Three Formulations of Ultra-low Dose Estriol Vaginal Gel (0.005%, NCT02967510 | ITF Research Pharma, S.L.U. | Phase 2 |
| Completed | Effects of a Moisturizing Cream on Vaginal and Vulvar Mucous Membranes NCT02937805 | Petra Larmo | N/A |
| Completed | Prospective, Open-Label, Single-Center, Non-Comparative Study to Assess the Use of Pixel CO2 Laser System (Fem NCT02747641 | Alma Lasers Inc. | N/A |
| Completed | A Clinical Trial to Assess the Safety of 0.005 % Estriol Vaginal Gel in Hormone Receptor-Positive Postmenopaus NCT02413008 | ITF Research Pharma, S.L.U. | Phase 2 |
| Unknown | Evaluate the Efficacy, Safety and Tolerability of a Non-hormonal Intravaginal Gel in Postmenopausal Women With NCT02571127 | Farmoquimica S.A. | Phase 4 |
| Unknown | Clinical Study of the CO2RE Laser Device Performance for Vaginal Atrophy Treatments NCT02704741 | Syneron Medical | N/A |
| Completed | Intravaginal Prasterone (DHEA) Against Vulvovaginal Atrophy Associated With Menopause NCT02013544 | EndoCeutics Inc. | Phase 3 |
| Completed | A Pharmacokinetic Study of Vaginally and Intravenously Administered Oxytocin NCT01975129 | PepTonic Medical AB | Phase 2 |
| Terminated | Efficacy and Safety Of Spil's Estradiol Vaginal Tablet NCT01753102 | Sun Pharmaceutical Industries Limited | Phase 3 |
| Unknown | VG101 Phase I/II to Treat Vulvar and Vaginal Atrophy in Post-Menopausal Women NCT00453089 | Bionovo | Phase 1 / Phase 2 |
| Completed | Dose-relationship of Vaginally Administrated Oxytocin in Postmenopausal Women NCT01987804 | PepTonic Medical AB | Phase 2 |
| Completed | Dehydroepiandrosterone (DHEA) Against Vaginal Atrophy NCT01358760 | EndoCeutics Inc. | Phase 3 |
| Completed | DHEA Against Vaginal Atrophy - Safety Study of 12 Months NCT01256671 | EndoCeutics Inc. | Phase 3 |
| Completed | DHEA Against Vaginal Atrophy - 3-Month Efficacy Study NCT01256684 | EndoCeutics Inc. | Phase 3 |
| Completed | Vaginal Inflammation Markers in Postmenopausal Women With and Without Symptoms of Vaginal Inflammation NCT01899612 | Insel Gruppe AG, University Hospital Bern | — |
| Completed | Study of Oxytocin to Treat Vaginal Atrophy in Postmenopausal Women NCT01432470 | PepTonic Medical AB | Phase 2 |
| Completed | The Effects of Local Vaginal Estrogen in Postmenopausal Women With Pelvic Organ Prolapse NCT00803335 | TriHealth Inc. | Phase 3 |
| Completed | Study to Determine Efficacy & Safety of a Low Concentration Estriol (0.005%) in Postmenopausal Vaginal Atrophy NCT04574999 | Italfarmaco S.A | Phase 3 |
| Completed | Efficacy and Safety of Clino-san on Vaginal Dryness of Breast Cancer Patients NCT00607295 | Seoul National University Hospital | Phase 3 |
| Completed | Topical DHEA Against Vaginal Atrophy NCT01846442 | EndoCeutics Inc. | Phase 3 |
| Completed | DHEA Bioavailability Following Administration of Vaginal Suppositories in Post-Menopausal Women With Vaginal A NCT00429806 | CHU de Quebec-Universite Laval | Phase 1 |
| Completed | Study Evaluating Bazedoxifene/Conjugated Estrogen Combinations in Vasomotor Symptoms Associated With Menopause NCT00238732 | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 3 |