| Not Yet Recruiting | Rapid Identification of Infectious Pathogens in Severe Pneumonia Guided by Bronchoscopic Imaging and Lung CT NCT07308340 | The First Hospital of Jilin University | — |
| Active Not Recruiting | AI-Driven Accurate Diagnosis of Pathogens in Severe Pneumonia NCT07461714 | Guangzhou Medical University | — |
| Enrolling By Invitation | Diagnostic Application of AI-ROSE in Severe Pneumonia NCT07113951 | The First Affiliated Hospital with Nanjing Medical University | — |
| Not Yet Recruiting | Herpes Simplex Virus Type 1 Infection/Reactivation of Patients With Severe Pneumonia（the HSV-SP Study） NCT06936683 | Second Affiliated Hospital of Guangzhou Medical University | — |
| Not Yet Recruiting | Enhancing Pediatric Acute Care Through Adaptive E-Learning and In-Person Skills Practice in Tanzania NCT06635733 | Stanford University | N/A |
| Not Yet Recruiting | Species-specific Bacterial Detector for Fast Pathogen Diagnosis of Severe Pneumonia NCT05143593 | Chinese Medical Association | N/A |
| Not Yet Recruiting | Rapid Diagnosis of Severe Respiratory Tract Infectious Diseases and Screening of Biomarkers for Stratified Dia NCT06533514 | Chinese PLA General Hospital | — |
| Active Not Recruiting | Dynamic Pattern of Etiology, Immunoinflammatory Factors and Their Association With Prognosis of Severe Pneumon NCT06538441 | Shanghai General Hospital, China | — |
| Recruiting | The Application of Different Sedation Protocols in ICU Patients With Severe Pneumonia NCT06514781 | Xiangya Hospital of Central South University | — |
| Completed | Fiberoptic Bronchoscopy in Severe Ventilator-associated Pneumonia NCT07149909 | Benha University | N/A |
| Recruiting | Microbiome and Host Susceptibility in Severe Pneumonia, a Prospective, Multicenter, Cohort Study NCT06114784 | First Affiliated Hospital of Zhejiang University | — |
| Unknown | Research on the Treatment of Severe Community-acquired Pneumonia in Children NCT05768204 | Baoping XU | Phase 4 |
| Completed | Efficacy of Intravenous Amboxol Hydrochloride as an Adjunct Therapy for Severe Pneumonia in Critically Ill Pat NCT05663905 | National University of Malaysia | Phase 4 |
| Completed | Lung Response to a Higher PEEP During Severe Pneumonia: a CT Study NCT07112976 | Istituto Clinico Humanitas | — |
| Suspended | Yinhu Qingwen Granula for the Treatment of Severe CoVID-19 NCT04310865 | Zhong Wang | Phase 2 / Phase 3 |
| Completed | Treatment of COVID-19 Positive/Negative Bangladeshi Adults With Severe Respiratory Complaints by a Locally Mad NCT05158842 | International Centre for Diarrhoeal Disease Research, Bangladesh | N/A |
| Unknown | Early Identification and Severity Prediction of Acute Respiratory Infectious Disease NCT04955756 | Huashan Hospital | N/A |
| Unknown | Construction of Special Disease Cohort Database and Biological Sample Holographic Database of Severe Pneumonia NCT04882436 | Ruijin Hospital | — |
| Unknown | Serum IL-6 and Soluble IL-6 Receptor in Severe COVID-19 Pneumonia Treated With Tocilizumab NCT04359667 | University Hospital for Infectious Diseases, Croatia | — |
| Unknown | Molecular Diagnosis and Prognosis of Severe Pulmonary Infection Immunosuppressed Hosts NCT04395066 | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | — |
| Completed | One Year Follow-ups of Patients Admitted to Spanish Intensive Care Units Due to COVID-19 NCT04457505 | Consorcio Centro de Investigación Biomédica en Red (CIBER) | — |
| Terminated | Reparixin in COVID-19 Pneumonia - Efficacy and Safety NCT04794803 | Dompé Farmaceutici S.p.A | Phase 2 / Phase 3 |
| Unknown | Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cells for the Treatment of Severe Viral Pneumonian NCT04282928 | Shanghai East Hospital | Phase 1 |
| Completed | Feasibility and Acceptability Followed by Effectiveness of bCPAP for Treatment of Children Aged 1-59 Months Wi NCT03870243 | International Centre for Diarrhoeal Disease Research, Bangladesh | N/A |
| Completed | Impact of Pulse Oximetry on Hospital Referral Acceptance in Children Under 5 With Severe Pneumonia NCT03588377 | Aga Khan University | N/A |
| Unknown | The Effect of Prone Position Drainage on the Efficacy of Severe Pneumonia，a Multicenter Randomized Controlled NCT03891212 | Xiangya Hospital of Central South University | N/A |
| Completed | Impact of Systematic Early Tuberculosis Detection Using Xpert MTB/RIF Ultra in Children With Severe Pneumonia NCT03831906 | Institut National de la Santé Et de la Recherche Médicale, France | N/A |
| Recruiting | Fulminant Severe CAP - an Observational Study NCT06516601 | University of Trieste | — |
| Recruiting | Detection and Characterization of Lower Respiratory Infections in Critically Ill Patients NCT01068990 | Asan Medical Center | — |
| Completed | Community Case Management of the Severe Pneumonia With Oral Amoxicillin in Children 2-59 Months of Age NCT01192789 | Aga Khan University | N/A |
| Completed | Randomized Controlled Trial (RCT) in Children With Severe Pneumonia NCT00455468 | International Centre for Diarrhoeal Disease Research, Bangladesh | N/A |