| Not Yet Recruiting | ENA-001 for Post Operative Respiratory Depression (PORD) NCT06137638 | Enalare Therapeutics Inc. | Phase 2 |
| Recruiting | Dexmedetomidine vs Propofol in High-Risk ERCP Patients NCT07166614 | Sisli Hamidiye Etfal Training and Research Hospital | N/A |
| Active Not Recruiting | ENA-001 for Opioid Induced Respiratory Depression NCT06967259 | Enalare Therapeutics Inc. | Phase 1 |
| Recruiting | Transcutaneous Electrical Stimulation for Apnea Detected by Capnography NCT06823661 | University of Toronto | N/A |
| Recruiting | Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments NCT06777758 | Kaohsiung Veterans General Hospital. | Phase 4 |
| Not Yet Recruiting | Effect of Propofol Versus Remimazolam Intravenous Anesthesia on Respiratory Depression NCT06816173 | Second Affiliated Hospital of Wenzhou Medical University | Phase 4 |
| Recruiting | Effect of Percutaneous Electrical Acupoint Stimulation on the Improvement of Incidence of Adverse Respiratory NCT06772961 | Nanjing First Hospital, Nanjing Medical University | N/A |
| Not Yet Recruiting | Hemidiaphragmatic Paralysis Following Supraclavicular Brachial Plexus Blockade. NCT06491498 | Sohag University | — |
| Withdrawn | Precision Medicine in Anesthesia NCT04495452 | University of Alabama at Birmingham | — |
| Recruiting | Closed-Loop O2 Use During High Flow Oxygen Treatment of Critical Care Adult Patients (CLOUDHFOT) NCT06374589 | Başakşehir Çam & Sakura City Hospital | N/A |
| Completed | VitalThings Guardian Contactless Monitoring NCT06083272 | VitalThings | — |
| Unknown | Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prosp NCT06064409 | Yonsei University | — |
| Completed | Oliceridine in Patients With Acute Burn Injuries NCT05465226 | University of Tennessee | Phase 4 |
| Completed | Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age NCT05391555 | University of California, San Francisco | Phase 2 / Phase 3 |
| Unknown | Influence of Δ9-tetrahydrocannabinol (THC) on Oxycodone Induced Ventilatory Depression in Healthy Volunteers NCT05235503 | Leiden University Medical Center | Phase 4 |
| Active Not Recruiting | Vital Signs-Integrated Patient-Assisted Intravenous Opioid Analgesia for Post Surgical Pain NCT04011163 | KK Women's and Children's Hospital | Phase 2 / Phase 3 |
| Unknown | Multimodal Perioperative Pain Management: ComfortSafe Program NCT04046068 | Georgetown University | — |
| Completed | IPI-Guided Monitoring for Oxygen Desaturation in ERCP NCT07451704 | Merve Gökçe | N/A |
| Unknown | Incidence OIRD Medical and Trauma Patients NCT03948880 | Community Health System | — |
| Completed | Single Dose Crossover Study to Compare the Respiratory Drive After Administration of Belbuca, Oxycodone and Pl NCT03996694 | BioDelivery Sciences International | Phase 1 |
| Completed | Effect of Opioids on Ventilation in Children With Obstructive Sleep Apnea NCT03938259 | Baylor College of Medicine | — |
| Completed | Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression NCT04301895 | University of California, San Francisco | Phase 1 |
| Unknown | TAES Improve the Function of Respiration and Circulation on Elderly Patients Undergoing Colonoscopy Procedure NCT03775122 | RenJi Hospital | N/A |
| Terminated | Precision Medicine in Anesthesia: Genetic Component in Opioid-induced Respiratory Depression NCT03441282 | University of Alabama at Birmingham | — |
| Withdrawn | Incidence of Opioid-Induced Respiratory Depression in Medical and Trauma Patients NCT03647696 | Poudre Valley Health System | — |
| Completed | Detection of Postoperative Respiratory Depression in High Risk Patients Utilizing Minute Ventilation Monitorin NCT04017702 | Yale University | — |
| Unknown | Respiratory Depression in Women With BMI≥30 Underwent Spinal Anesthesia With Intrathecal Morphine in Elective NCT02819661 | Rambam Health Care Campus | N/A |
| Completed | Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Ton NCT02987985 | University of Saskatchewan | Phase 3 |
| Completed | PRediction of Opioid-induced Respiratory Depression In Patients Monitored by capnoGraphY NCT02811302 | Medtronic - MITG | N/A |
| Completed | Determination of the Clinical Impact of Continuous Surveillance Monitoring (SM) and Utility of IPI. NCT03050983 | Medtronic - MITG | — |
| Active Not Recruiting | Vital-signs-integrated Patient-assisted Intravenous Opioid Analgesia NCT02804022 | KK Women's and Children's Hospital | Phase 2 |
| Completed | The Use of Low Dose Prophylactic Naloxone Infusion to Prevent Respiratory Depression With Intrathecal Morphine NCT02885948 | University College Dublin | Phase 4 |
| Terminated | Assessment of a Oral Endotracheal Tube Fastener on Patients Intubated With Oral Endotracheal Tubes NCT02760927 | Hollister Incorporated | N/A |
| Completed | Clinical Utility of Capnography in the PACU( Post-anaesthesia Care Unit) NCT02707003 | Medtronic - MITG | — |
| Completed | Anesthetic Optimization in Scoliosis Surgery NCT02481570 | University of Florida | N/A |
| Terminated | OSA Screen Negative With Spinal Duramorph NCT03151226 | Wake Forest University Health Sciences | N/A |
| Completed | Postoperative Respiratory Monitoring After Neuraxial Opioid Administration for Cesarean Delivery NCT02417038 | Stanford University | — |
| Completed | Predictors of Opioid-Induced Respiratory Depression (OIRD) NCT02473354 | Duke University | Phase 1 |
| Completed | An Observational Study of Post-cesarean Delivery Respiratory Patterns Using a Non-invasive Minute Ventilation NCT02903173 | Duke University | — |
| Completed | Effects of Sequential Exposure to Nitrogen Dioxide and Ozone in Healthy Adult Human Volunteers. NCT02133586 | Environmental Protection Agency (EPA) | N/A |
| Completed | The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures NCT01969227 | Massachusetts General Hospital | N/A |
| Completed | Detecting Post-Operative Respiratory Depression in Children NCT01843933 | Yale University | N/A |
| Completed | Safer Births - Reducing Perinatal Mortality NCT01869582 | Helse Stavanger HF | N/A |
| Completed | Reformative Versus Single Step Dilation Percutaneous Dilatational Tracheostomy NCT03141294 | The First Affiliated Hospital with Nanjing Medical University | N/A |
| Unknown | Magnesium for Neonatal Neuroprotection and Mothers NCT01482078 | University of British Columbia | — |
| Completed | Effect of Interscalene Block on Ventilatory Function NCT01740453 | Pierre and Marie Curie University | Phase 4 |
| Terminated | Study of Respiratory Depression When Using a Hydromorphone Pain Protocol NCT01784991 | Albert Einstein Healthcare Network | N/A |
| Completed | Acupuncture for Sedation in the Intensive Care Unit (ICU) NCT01362270 | Oregon Health and Science University | N/A |
| Unknown | Effect of Postoperative Girdle Following Abdominal Surgery on Pulmonary Function, Mobilisation and Postoperati NCT01517217 | Karolinska Institutet | N/A |
| Completed | Vital Sign Monitoring With Continuous Pulse Oximetry and Wireless Clinician Notification After Surgery NCT02907255 | McMaster University | N/A |
| Completed | Cardiopulmonary Responses to Exposure to Ozone and Diesel Exhaust NCT01874834 | Environmental Protection Agency (EPA) | N/A |
| Terminated | Incidence of Respiratory Depression in Cesarean Section NCT01181843 | Wake Forest University | — |
| Terminated | Effects of Osteopathic Treatment on Pulmonary Function After Coronary Artery Bypass Graft Surgery NCT01714791 | Hartcentrum Hasselt | N/A |
| Completed | Testing of the Apnea Prevention Device NCT00875134 | Oregon Health and Science University | Phase 1 / Phase 2 |
| Completed | Long-term Extension Study of BEMA™ Fentanyl NCT00696137 | BioDelivery Sciences International | Phase 3 |
| Completed | Dexmedetomidine for the Control of Post-Operative Pain in Thoracotomy Patients NCT00345384 | Baylor Research Institute | Phase 1 / Phase 2 |
| Completed | Observation of Respiration Following Regional Anaesthesia With Intrathecal Opioids for Caesarean Section NCT00544947 | NHS Greater Clyde and Glasgow | — |