| Recruiting | Machine Learning-based Surgical Guidance System for Robot-assisted Rectal Surgery NCT05652361 | Technische Universität Dresden | N/A |
| Active Not Recruiting | The Effect of Art Therapy in Patients Undergoing Colorectal Cancer NCT07137000 | Saglik Bilimleri Universitesi | N/A |
| Recruiting | Neoadjuvant FOLFIRINOX and Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer Patients NCT06812728 | Menoufia University | Phase 2 |
| Recruiting | Target-specific immunoPET Imaging of Digestive System Carcinoma NCT06715839 | RenJi Hospital | N/A |
| Recruiting | Biological Tumor Infiltrating Lymphocytes Therapy With Immunotherapy for Colon and Rectum Cancer NCT06530303 | Essen Biotech | Phase 1 / Phase 2 |
| Completed | A Clinical Evaluation of AI Solutions Developed in the CHAIMELEON Project for Cancer: Prostate, Lung, Breast, NCT06950996 | Instituto de Investigacion Sanitaria La Fe | — |
| Not Yet Recruiting | Conformal Sphincter-Preservation Operation Versus InterSphincteric Resection on Anal Function in Low Rectal Ca NCT06567756 | Changhai Hospital | N/A |
| Not Yet Recruiting | Assessment of DW-MRI Measures : Reproducibility and Repeatability in Pelvic Imaging on MR-Linac With Healthy V NCT06458725 | Jules Bordet Institute | N/A |
| Recruiting | Image-Guided Surgery In The Treatment Of Rectal Cancer (AR_CRC) NCT06805045 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | N/A |
| Unknown | End to End Versus Side to End Anastomosis After Anterior Resection of Cancer Rectum NCT06311279 | Sohag University | N/A |
| Recruiting | SGM-101 in Colorectal Brain Metastases. NCT04755920 | Leiden University Medical Center | Phase 2 |
| Recruiting | Online Adaptive Radiotherapy Using a Novel Linear Accelerator (ETHOS) NCT06116019 | Charite University, Berlin, Germany | — |
| Not Yet Recruiting | Reconstruction of the Pelvic Floor and Perineal Wound After Rectal ELAPE NCT06066931 | Kuban State Medical University | N/A |
| Withdrawn | Regorafenib and XmAb20717 in Treatment of High-risk Patients With Colorectal Cancer With Radiographic Occult M NCT05900648 | M.D. Anderson Cancer Center | Phase 2 |
| Recruiting | Adaptive Symptom Self-Management Immunotherapy Study NCT05715255 | University of Arizona | N/A |
| Active Not Recruiting | Exploring the Effect of Colonic J-pouch in Anorectal Preservation Surgery for Ultra-low Rectal Cancer. NCT06601985 | Shanghai 10th People's Hospital | — |
| Suspended | Natural Killer (NK) Cells in Combination With Interleukin-2 (IL-2) and Transforming Growth Factor Beta (TGFbet NCT05400122 | David Wald | Phase 1 |
| Recruiting | Improving Care for Rural Patients With Solid Tumors NCT04916990 | University of Colorado, Denver | N/A |
| Unknown | Perioperative Exercise and Nutritional Optimisation Prehabilitation Before Surgery for Patients With Peritonea NCT05305820 | Dublin City University | N/A |
| Unknown | Low Tie Versus High Tie of the Inferior Mesenteric Vein During Colorectal Cancer Surgery: A Randomized Clinica NCT05411783 | San Carlo di Nancy Hospital | N/A |
| Unknown | Bacteriological Differences Between Transanal and Laparoscopic Total Mesorectal Excision for Rectal Cancer. NCT05201872 | Yanhong Deng | — |
| Unknown | Oncological Differences Between Transanal and Laparoscopic Total Mesorectal Excision for Rectal Cancer. NCT05201885 | Yanhong Deng | — |
| Recruiting | Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes NCT04907643 | Cedars-Sinai Medical Center | N/A |
| Active Not Recruiting | Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer NCT04963283 | University of Colorado, Denver | Phase 2 |
| Recruiting | Effects of Modified Precision Functional Sphincter-Preserving Surgery (PPS) on Ultralow Rectal Cancer NCT05245565 | Shanghai 10th People's Hospital | — |
| Unknown | MRI Split Scar Sign as a Predictor to Complete Pathologic Response After Neoadjuvant Chemoradiation in Rectal NCT04745091 | Alexandria University | — |
| Completed | Patient-Derived Organoids for Rectal Cancer NCT04371198 | Duke University | N/A |
| Unknown | The Role of Pelvic Peritonization in Laparoscopic or Robotic Low Anterior Resection NCT03699761 | Southwest Hospital, China | N/A |
| Recruiting | Neo-adjuvant Pembrolizumab and Radiotherapy in Localised MSS Rectal Cancer NCT04109755 | University Hospital, Geneva | Phase 2 |
| Completed | A Cohort of Predictive Factor of Pathologic Complete Response After Preoperative Neoadjuvant in Rectum Cancer NCT04443985 | Mahidol University | — |
| Unknown | Total Neoadjuvant Therapy Followed by 'Watch and Wait' Approach or Organ Preservation for Low-risk Rectal Canc NCT04405206 | Peking University Cancer Hospital & Institute | — |
| Withdrawn | Determining Early Development of Faecal Incontinence and Anorectal Muscle Function After Surgery for Rectal Ca NCT03257332 | Slagelse Hospital | — |
| Completed | Effectiveness and Implementation of mPATH-CRC NCT03843957 | Wake Forest University Health Sciences | N/A |
| Recruiting | Biomarkers for Predicting Neoadjuvant Chemoradio-resistance for Middle-low Advanced Rectal Cancer NCT03573791 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | — |
| Active Not Recruiting | PRELOOP Trial: Synthetic Versus Biological Mesh for Prevention of Incisional Hernia After Loop-ileostomy Closu NCT03445936 | University of Oulu | N/A |
| Completed | Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery NCT02997553 | Institut de Cancérologie de Lorraine | Phase 3 |
| Completed | Efficacy of Colonoscopy, Colon Capsule and Fecal Immunological Test for Colorectal Cancer Screening NCT02738359 | Hôpital Edouard Herriot | — |
| Completed | Effects of High-intensity Training Compared to Resistance Training in Cancer Patients Undergoing Radiotherapy NCT03252821 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | N/A |
| Completed | Project HERO: Health Empowerment & Recovery Outcomes NCT03345563 | Rutgers, The State University of New Jersey | N/A |
| Unknown | Clinical Effect of Neoadjuvant Hierarchical Treatment Based on Chemotherapy NCT03071198 | Harbin Medical University | N/A |
| Unknown | Removal Time of Urinary Catheter After Laparoscopic Anterior Resection of the Rectum NCT03065855 | Peking Union Medical College Hospital | N/A |
| Unknown | Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery NCT02958566 | University of Illinois College of Medicine at Peoria | Phase 4 |
| Completed | Non-Operative Radiation Management of Adenocarcinoma of the Lower Rectum NCT02641691 | Washington University School of Medicine | Phase 2 |
| Completed | Phase I of SGM-101 in Patients With Cancer of the Colon, Rectum or Pancreas NCT02973672 | Surgimab | Phase 1 / Phase 2 |
| Completed | Robotic Low Rectum Anterior Resection NCT04015804 | Institut du Cancer de Montpellier - Val d'Aurelle | N/A |
| Terminated | Effects of S-1 and Capecitabine on Coronary Artery Blood Flow NCT02216149 | Heikki Joensuu | Phase 2 |
| Completed | Self-monitoring and Reminder Texts to Increase Physical Activity After Cancer: a Pilot Randomized Controlled T NCT02966054 | University of California, San Francisco | N/A |
| Unknown | BASE HSP110 : A New Therapeutic Target and a New Marker for Prognosis of Type MSI Colorectal Cancer NCT02458664 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Engagement of Patients With Advanced Cancer NCT02966509 | Stanford University | N/A |
| Completed | The Value of Laparoscopic Ultrasound in Patients Undergoing Laparoscopic Resection for Cancer of the Colon or NCT02079389 | Odense University Hospital | N/A |
| Completed | Study of the Preservation of the Left Colic Artery on Rectum Cancer Surgery NCT01979029 | Jian Suo | N/A |
| Completed | A Lymph Node Metastasis Predictor (LN-MASTER) in Rectal Cancer NCT05493930 | Peking Union Medical College | — |
| Unknown | Treatment of Patients With Advanced Rectum Cancer With Capecitabine and Oxaliplatin Before, Under and After Ra NCT00964457 | Copenhagen University Hospital at Herlev | Phase 2 |
| Completed | Study of Neoadjuvant CT With Selective Radiotherapy in Patients With Intermediate-Risk Cancer Rectum NCT00909987 | Grupo Espanol Multidisciplinario del Cancer Digestivo | Phase 2 |
| Completed | Evaluating Factors Affecting Survival in Colon and Rectum Cancer NCT05388513 | Umraniye Education and Research Hospital | — |
| Completed | Computed Tomography-guided Brachytherapy Plus Chemotherapy for Locally Recurrent Rectum Cancer NCT02423226 | The First People's Hospital of Changzhou | Phase 2 |
| Completed | Rectal Study: Value of Repeated FDG-PET-CT Scans in Rectal Cancer NCT00576563 | Maastricht Radiation Oncology | N/A |
| Completed | Cancer Prevention and Treatment Among African American Older Adults: Treatment Trial NCT00509444 | Johns Hopkins Bloomberg School of Public Health | Phase 3 |
| Completed | Partnership for Healthy Seniors NCT00379743 | Johns Hopkins Bloomberg School of Public Health | N/A |
| Completed | Safety Study of Rapamycin Administered Before and During Radiotherapy to Treat Rectum Cancer NCT00409994 | Maastricht Radiation Oncology | Phase 1 / Phase 2 |
| Completed | Irinotecan and Cetuximab for Colorectal Cancer as Second Line Therapy NCT00336856 | University of Pittsburgh | Phase 2 |
| Completed | QoL of Colorectal Cancer Patients and Spouses NCT04744792 | Cihangir Akyol | — |