| Withdrawn | UNITY VCS Vitreoretinal Surgery NCT07054281 | Alcon Research | N/A |
| Not Yet Recruiting | New Pattern of Retinal Laser Treatment for PDR NCT07315802 | Eye & ENT Hospital of Fudan University | N/A |
| Recruiting | Single Session vs Multiple-Session Panretinal Photocoagulation for Treatment of Proliferative Diabetic Retinop NCT06549023 | Vastra Gotaland Region | N/A |
| Completed | Biological Changes in Fibrovascular Membranes of Patients With Proliferative Diabetic Retinopathy Following Fa NCT07144865 | Bojie Hu | N/A |
| Unknown | OCT and OCT-A Afer Diabetic Vitrectomy in PDR NCT05938491 | Assiut University | — |
| Completed | VISUPRIME® Eye Drops NCT05677685 | VISUfarma SpA | N/A |
| Completed | Outcomes of Retinal Re-surgeries in Silicone Oil Filled Eyes NCT06583798 | Ahalia Foundation Eye Hospital | — |
| Unknown | Establishment and Validation of a Risk Prediction Model for Long-term Low Vision After Vitrectomy in PDR Patie NCT05631054 | Tianjin Medical University Eye Hospital | — |
| Active Not Recruiting | Phase 2 Spectra Study to Evaluate the Safety and Efficacy of OPL-0401 in Patients With Diabetic Retinopathy NCT05393284 | Valo Health, Inc. | Phase 2 |
| Completed | Observation of the Efficacy of Different Vitrectomy Systems to Treat Proliferative Diabetic Retinopathy NCT05446948 | Tianjin Medical University Eye Hospital | N/A |
| Unknown | Effect of Postvitrectomy Proactive Use of Conbercept on Postoperative Complications in PDR Patients NCT05642793 | Peking University Third Hospital | Phase 2 |
| Unknown | Anti-VEGF in Real-world NCT05222633 | Wenbin Wei | — |
| Completed | A Study on the Treatment Strategy of NVG Secondary to PDR NCT05156021 | Ruijin Hospital | N/A |
| Completed | Discovering Early Biomarkers in Circulating Endothelial Cells for Diabetes Complications by Single Cell RNA Se NCT05169502 | Aarhus University Hospital | — |
| Completed | Comparison of Surgery Outcome Between Preoperative IVR and Intraoperative IVR in PPV for PDR NCT05408416 | Peking University People's Hospital | N/A |
| Completed | Efficacy and Safety Comparison of IVR and IVC Before Vitrectomy in Proliferative Diabetic Retinopathy NCT05414149 | Peking University People's Hospital | N/A |
| Completed | Macular Perfusion Changes After Anti-VEGF Versus Targeted Retinal Photocoagulation in Proliferative Diabetic R NCT04674254 | Cairo University | Phase 4 |
| Completed | Study of Efficacy and Safety of Brolucizumab Versus Panretinal Photocoagulation Laser in Patients With Prolife NCT04278417 | Novartis Pharmaceuticals | Phase 3 |
| Unknown | Pre-vitrectomy Intravitreal Ranibizumab for Patients With Proliferative Diabetic Retinopathy Combined With Dia NCT04464694 | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | Phase 4 |
| Unknown | Gas Tamponade for Prevention of Postoperative Vitreous Hemorrhage in Diabetics NCT04380077 | Rush Eye Associates | N/A |
| Unknown | Intravitreal Bevacizumab vs Laser vs Combination of Bevacizumab and Modified Laser in PDR NCT04800679 | Shahid Beheshti University of Medical Sciences | Phase 2 |
| Unknown | Conbercept vs Panretinal Photocoagulation for the Management of Proliferative Diabetic Retinopathy NCT02911311 | Sun Yat-sen University | N/A |
| Completed | The Effect of IVA for Preventing Postvitrectomy Hemorrhage in PDR NCT05478967 | Peking University People's Hospital | N/A |
| Unknown | Anti-VEGF Instead of Intraoperative PRP in Proliferative Diabetic Retinopathy NCT03633266 | Wenzhou Medical University | N/A |
| Unknown | Retrospective Review of Proliferative Diabetic Retinopathy Patients NCT03609996 | Elman Retina Group | — |
| Unknown | Cryoapplication Versus Anti-VEGF Before Diabetic Vitrectomy NCT05514925 | Khairallah Moncef | Phase 4 |
| Completed | Macular Hole After Diabetic Vitrectomy NCT03525899 | National Taiwan University Hospital | — |
| Completed | Effectiveness of Multimodal Imaging for the Evaluation of Retinal Oedema And New vesseLs in Diabetic Retinopat NCT03490318 | Belfast Health and Social Care Trust | — |
| Unknown | Day Regimes of CONbercept on CytokinEs of PDR Patients Undergoing Vitrectomy - Trial (CONCEPT) NCT03506750 | The First Affiliated Hospital with Nanjing Medical University | Phase 4 |
| Completed | The Individually-Marked Panretinal Laser phoTocoagulation for Proliferative Diabetic Retinopathy Study (TREAT) NCT03113006 | Odense University Hospital | N/A |
| Completed | Anti-VEGF vs. Prompt Vitrectomy for VH From PDR NCT02858076 | Jaeb Center for Health Research | Phase 2 / Phase 3 |
| Completed | Intravitreal Aflibercept for Retinal Non-Perfusion in Proliferative Diabetic Retinopathy NCT02863354 | Charles C Wykoff, PhD, MD | Phase 2 |
| Completed | Conbercept Injection in Treatment of Severe Proliferative Diabetic Retinopathy NCT02816710 | Ruijin Hospital | Phase 4 |
| Unknown | Endolaserless Vitrectomy With Intravitreal IAI for PDR-Related VH NCT02976012 | Southeast Retina Center, Georgia | Phase 1 / Phase 2 |
| Completed | Study to Evaluate Effects of Emixustat Hydrochloride in Subjects With Proliferative Diabetic Retinopathy NCT02753400 | Kubota Vision Inc. | Phase 2 |
| Completed | PRP vs Bevacizumab for PDR Treatment NCT02705274 | Marashi Eye Clinic | Phase 2 / Phase 3 |
| Unknown | Evaluation of Treatment of High riSk proLiferative Diabetic retinopathY With Intravitreal Aflibercept injectio NCT02630277 | Valley Retina Institute | Phase 2 |
| Unknown | Analysis of Aqueous and Vitreous Humor NCT02067013 | California Retina Consultants | Phase 2 |
| Unknown | 25-G Vitrectomy With Ranibizumab or Triamcinolone Acetonide on PDR in China-Randomized Clinical Trial NCT02447185 | JUNYAN ZHANG | Phase 3 |
| Unknown | 25-Gauge Vitrectomy With Ranibizumab or Triamcinolone Acetonide on Proliferative Diabetic Retinopathy in China NCT02328118 | JUNYAN ZHANG | Phase 2 / Phase 3 |
| Completed | Nd:YAG Laser Hyaloidotomy for Premacular Hemorrhage in Diabetic Eyes NCT04285151 | Tanta University | N/A |
| Completed | The Individually Marked Panretinal lasEr phoTokoagUlation for Proliferative Diabetic Retinopathy Study - DETEC NCT02157350 | Odense University Hospital | Phase 3 |
| Completed | Intravitreal Injection of Ranibizumab Versus Sham Before Vitrectomy in Patients With Proliferative Diabetic Re NCT02857491 | Sun Yat-sen University | N/A |
| Completed | Genetic Markers and Proliferative Diabetic Retinopathy NCT02879422 | CHU de Reims | N/A |
| Completed | Diabetes PRP and OCT NCT01928550 | Oregon Health and Science University | — |
| Completed | Bevacizumab and Peripheral Retinal Changes on Wide Field Angiography in Diabetic Macular Edema NCT02096874 | King Khaled Eye Specialist Hospital | Phase 4 |
| Completed | Treatment With Intravitreal Aflibercept Injection For Proliferative Diabetic Retinopathy, The A.C.T Study NCT01813773 | Ophthalmic Consultants of Long Island | Phase 2 / Phase 3 |
| Unknown | Diabetic Macular Edema and Diabetic Retinopathy Screening (TeleMed) With Automated Retinal Photography NCT01790945 | Retina Institute of Hawaii | — |
| Completed | Surgical Outcomes for Proliferative Diabetic Retinopathy by Preoperative Glycemic Control and Renal Function NCT03522311 | Kyorin University | — |
| Terminated | Safety and Efficacy of Low-Fluence PRP for PDR NCT01737957 | Asociación para Evitar la Ceguera en México | N/A |
| Completed | Impact of Intravitreal Aflibercept Injections on Capillary Non-Perfusion NCT01724554 | Ophthalmic Consultants of Boston | Phase 1 / Phase 2 |
| Completed | Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy NCT01627977 | Federal University of São Paulo | Phase 3 |
| Unknown | Effect of Folic Acid, Vitamin B6 and Vitamin B12 in Diabetic Retinopathy NCT01921192 | University of Catania | Phase 4 |
| Completed | Intravitreal Bevacizumab for Proliferative Diabetic Retinopathy NCT01724385 | Khon Kaen University | Phase 4 |
| Unknown | Gene Expression in Patients With Epiretinal Membranes NCT01946451 | Medical University of Silesia | — |
| Completed | Retinal Laser by Multi-spot Photocoagulator and Driving Eligibility NCT01383772 | Moorfields Eye Hospital NHS Foundation Trust | N/A |
| Completed | Prospective Randomized Controlled Study of Intravitreal Injection of Bevacizumab for Proliferative Diabetic Re NCT01854593 | Nihon University | Phase 4 |
| Terminated | A Pilot Study on the Effects of ILARIS® on Patients With Proliferative Diabetic Retinopathy (PDRP) NCT01589029 | PD Dr. med. Stephan Michels | Phase 1 |
| Withdrawn | A Study of the Safety, Tolerability, and Efficacy of IVT Pre-op 0.3mg Pegaptanib Sodium Versus Sham, for Manag NCT01589718 | Greater Houston Retina Research | Phase 3 |
| Completed | Ozurdex for Treatment of Recalcitrant Diabetic Macular Edema NCT01571232 | Retina Macula Institute | Phase 2 |
| Completed | Prompt Panretinal Photocoagulation Versus Ranibizumab+Deferred Panretinal Photocoagulation for Proliferative D NCT01489189 | Jaeb Center for Health Research | Phase 3 |
| Completed | Propranolol for Diabetic Retinopathy NCT01535495 | University of Wisconsin, Madison | Phase 1 |
| Withdrawn | Changes in Vitreous Temperature During Phacoemulsification NCT01568242 | Asociación para Evitar la Ceguera en México | N/A |
| Unknown | PASCAL Laser Versus ETDRS Laser Associated With Intravitreal Ranibizumab (IVR) Versus Only IVR for Proliferati NCT02005432 | University of Sao Paulo | Phase 4 |
| Completed | Intravitreal Ozurdex After Pars Plana Vitrectomy for Proliferative Diabetic Retinopathy NCT01478737 | Anders Kvanta | Phase 2 |
| Unknown | Bevacizumab as Adjunctive Treatment to Laser Panretinal Photocoagulation for Proliferative Diabetic Retinopath NCT01389505 | Instituto do Coracao | Phase 2 |
| Unknown | Macular Tractional Retinoschisis in Proliferative Diabetic Retinopathy NCT01312207 | National Taiwan University Hospital | — |
| Completed | Vitrous Analysis in Proliferative Diabetic Retinopathy NCT01478763 | Anders Kvanta | — |
| Completed | Intravitreal Ranibizumab for Vitreous Hemorrhage Due to Proliferative Diabetic Retinopathy (N) NCT00996437 | Jaeb Center for Health Research | Phase 2 / Phase 3 |
| Unknown | Trial of Yellow 577 nm Laser Versus Green 532 nm Laser for Proliferative Diabetic Retinopathy NCT01044875 | University of Malaya | N/A |
| Completed | Topic Ketorolac Added to Panphotocoagulation in Proliferative Diabetic Retinopathy NCT00907114 | Hospital Juarez de Mexico | Phase 2 |
| Completed | Ocular Growth Factors Profile in Proliferative Retinopathies Before and After Intravitreal Bevacizumab NCT00776763 | Ophthalmological Association Edelweiss | Phase 2 |
| Unknown | Intravitreal Ranibizumab For Persistent New Vessels In Diabetic Retinopathy(Inipe Study) NCT00993525 | University of Sao Paulo | Phase 1 / Phase 2 |
| Completed | Compliance to Ophthalmic Follow-up Examinations and Surgical Outcome for Proliferative Diabetic Retinopathy NCT01307072 | Kyorin University | — |
| Completed | Pre- and Intra-operative Intravitreal Bevacizumab Injection in Diabetic Vitrectomy NCT00745498 | Seoul National University Bundang Hospital | N/A |
| Completed | Bevacizumab Versus Ranibizumab for Diabetic Retinopathy NCT00545870 | Ursula Schmidt-Erfurth, M.D. | Phase 3 |
| Terminated | Pain Using Reduced Fluence Parameters in Photocoagulation for Diabetic Retinopathy. NCT00802269 | Asociación para Evitar la Ceguera en México | Phase 4 |
| Completed | Ranibizumab for Treatment of Persistent Diabetic Neovascularization Assessed by Wide-Field Imaging NCT00606138 | Rush University Medical Center | Phase 1 / Phase 2 |
| Unknown | Macugen for Proliferative Diabetic Retinopathy Study With Extended Dosing (M-PDRS ED) NCT01486771 | Valley Retina Institute | Phase 4 |
| Completed | Morphological and Functional Retinal Changes Following Retinal Photocoagulation NCT00682240 | Medical University of Vienna | Phase 4 |
| Terminated | Changes in Macular Thickness After Patterns Scan Laser NCT00563628 | Asociación para Evitar la Ceguera en México | Phase 4 |
| Terminated | Changes in Electroretinogram and Contrast Sensitivity After PASCAL Treatment NCT00563043 | Asociación para Evitar la Ceguera en México | Phase 4 |
| Completed | Comparison of Small-gauge Vitrectomy and Conventional Vitrectomy for Proliferative Diabetic Retinopathy NCT01758757 | Kyorin University | N/A |
| Unknown | Evaluation of Ranibizumab in Proliferative Diabetic Retinopathy (PDR) Requiring Vitrectomy NCT00516464 | Retina Associates, Kansas City | Phase 3 |
| Completed | Use of Ranibizumab to Treat Rubeosis in Diabetics Prior to Cataract Surgery NCT01069341 | Bhagat, Neelakshi, M.D., M.P.H. | Phase 1 |
| Completed | Efficacy of PreOperative Bevacizumab for Diabetic Eye Disease NCT01041690 | Cairo University | N/A |
| Completed | Efficacy of Higher Cutting Rate in Microincision Vitrectomy for Proliferative Diabetic Retinopathy NCT02464800 | Kyorin University | — |
| Completed | Intravitreal Bevacizumab Pretreatment for Reducing Preretinal Hemorrhage in Diabetic Vitrectomy NCT00596505 | National Taiwan University Hospital | — |
| Completed | Laser-Ranibizumab-Triamcinolone for Proliferative Diabetic Retinopathy NCT00445003 | Jaeb Center for Health Research | Phase 3 |
| Terminated | Intravitreal Ranibizumab to Treat Macular Edema After Panretinal Photocoagulation (Phase II) NCT00668785 | Jumper, J. Michael, M.D. | Phase 2 |
| Completed | Bevacizumab and Long Acting Gas in Diabetic Vitrectomy NCT00656435 | National Taiwan University Hospital | Phase 3 |
| Completed | Effect of Macugen(Pegaptanib)on Surgical Outcomes and VEGF Levels in Diabetic Patients With PDR (Diabetic Reti NCT00446381 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Unknown | Intravitreal Bevacizumab for Retinal Disorders NCT00403026 | Narayana Nethralaya | N/A |
| Completed | Analgesic Effect of Etoricoxib (ARCOXIA®) 120MG During Retinal Laser Photocoagulation NCT00529594 | University of Sao Paulo | N/A |
| Terminated | Intravitreal Bevacizumab for Diabetic Retinopathy NCT00600262 | Asociación para Evitar la Ceguera en México | Phase 2 / Phase 3 |
| Completed | Macular Appearance After Diabetic Vitrectomy NCT00737022 | National Taiwan University Hospital | — |
| Completed | Vitreous Levels of Cysteine-rich 61 in Patients With Proliferative Diabetic Retinopathy NCT01920984 | National Taiwan University Hospital | N/A |
| Withdrawn | HLA and it Relation With the Development of Proliferative Diabetic Retinopathy in Mexican Population NCT00600236 | Asociación para Evitar la Ceguera en México | Phase 3 |
| Terminated | Study to Assess the Efficacy and Safety of Monthly Octreotide Intramuscular Injections in Patients With Prolif NCT00170742 | Novartis | Phase 3 |
| Completed | Macular Hole in Diabetic Retinopathy NCT00737074 | National Taiwan University Hospital | — |
| Completed | Fractalkine, a CX3C Chemokine, Act as a Mediator of Ocular Angiogenesis NCT00728598 | National Taiwan University Hospital | — |
| Completed | Intravitreal Bevacizumab for Surgical Treatment of Severe Proliferative Diabetic Retinopathy NCT01025934 | University of Campania Luigi Vanvitelli | Phase 4 |