| Not Yet Recruiting | Testing a Smart Medication Dispenser (Mobili®) to Help People With Chronic Conditions Take Their Medicine NCT07175545 | Lusofona University | N/A |
| Recruiting | Evaluation of the Impact of a Collaboration Between Hospital and Community Pharmacists at Hospital Discharge NCT06902779 | Pharmacie des Hopitaux de l'Est Lemanique | N/A |
| Recruiting | Empowering Patients to Improve Safety in Polymedication NCT06956820 | Leiden University Medical Center | N/A |
| Active Not Recruiting | Population Health Approach to Optimizing Medications in Older Adults NCT06110156 | Cedars-Sinai Medical Center | N/A |
| Recruiting | Improving Medication Management in World Trade Center Responders NCT07022990 | Icahn School of Medicine at Mount Sinai | N/A |
| Not Yet Recruiting | Holistic Integration for Healthy Longevity and Aging in Place NCT06882434 | National Taiwan University Hospital | N/A |
| Not Yet Recruiting | The Critical Care Recovery Program: Use of a Structured Clinic Visit to Reduce Adverse Drug Events in ICU Surv NCT06723860 | University of British Columbia | — |
| Active Not Recruiting | Prescribing Outcomes of a GP-Targeted Deprescribing Educational Intervention: A Cluster Randomized Trial NCT06470308 | University of Crete | N/A |
| Recruiting | Prioritising Patient Medication Review: Hospitals Reaching Out NCT06451692 | University of Southern Denmark | N/A |
| Enrolling By Invitation | The Effect of a Medication Coordinator on the Quality of Patients Medication Treatment NCT06383364 | University of Southern Denmark | N/A |
| Recruiting | Reduction of Polypharmacy in Elderly People With Multiple Diseases NCT05526963 | Martin-Luther-Universität Halle-Wittenberg | N/A |
| Completed | ALIGN: Aligning Medications With What Matters Most (Demonstration) NCT06335953 | Johns Hopkins University | N/A |
| Completed | Effect of Longitudinal Care in Primary Health Care: An Analysis From the Patient's Perspective NCT07320053 | IBS Granada | — |
| Recruiting | Evaluation of Medication Management Service NCT06273761 | The University of Hong Kong | N/A |
| Completed | Adapting the Shed-MEDS Deprescribing Intervention to Dementia Care in Assisted Living NCT05956665 | Vanderbilt University | N/A |
| Active Not Recruiting | Impact of Medications Review on Potentially Inappropriate Medications and Clinical Outcomes Among Hospitalized NCT05875623 | Monash University | N/A |
| Active Not Recruiting | Reducing High-Risk Geriatric Polypharmacy Via EHR Nudges R01 Trial NCT05656560 | Northwestern University | N/A |
| Active Not Recruiting | Less Is More: Optimized Pharmacotherapy With Improved coNtinuity of CarE in hospitaLized oLder peOple NCT05899114 | Radboud University Medical Center | N/A |
| Completed | Shared Decision Making About Medication Use for People With Multiple Health Problems NCT05156073 | Johns Hopkins University | N/A |
| Completed | A Patient-facing Tool to Reduce Opioid-Psychotropic Polypharmacy in People Living With Dementia (PLWD) NCT05628181 | University of Michigan | N/A |
| Unknown | Medication Review in Chronic Complex or Polymedicated Patients After Hospital Discharge. NCT05799430 | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | N/A |
| Completed | Deprescribing for Older Adults After Hospital Discharge in Home Health Care NCT05630144 | University of Rochester | N/A |
| Active Not Recruiting | Preemptive Pharmacogenomics Testing Among Geriatric Patients NCT05091879 | Geisinger Clinic | N/A |
| Unknown | Effectiveness of an Intervention of Pharmacotherapeutic Plans to Reduce Medication-related Problems in Geriatr NCT05944328 | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | N/A |
| Completed | Appropriate Prescribing for Older Adults With Multimorbidity (Pro-M) NCT05756478 | Geriatric Education and Research Institute | N/A |
| Unknown | OPTImization of Medication by Transdisciplinary Assessment of Drug Treatment in Elderly Hospitalized Patients NCT05387096 | University College Cork | N/A |
| Completed | Effects of Communication Training to Involve Older People in Decisions to DEPRESCRIBE Cardiometabolic Medicati NCT05507177 | University Medical Center Groningen | N/A |
| Recruiting | Telecommunication Technology-based Online Survey NCT06159699 | Tomsk National Research Medical Center of the Russian Academy of Sciences | — |
| Completed | Optimising Medication With Focus on Deprescribing in Frail Older People With Multidose Drug Dispensing Systems NCT05609981 | SIR Institute for Pharmacy Practice and Policy | N/A |
| Unknown | A Clinical Decision Support System and Patient Portal for Preventing Medication-related Falls in Older Patient NCT05449470 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Not Yet Recruiting | Individual Risk Profiles for Adverse Drug Reactions in Geriatric Patients NCT05247814 | RWTH Aachen University | — |
| Withdrawn | Protocol for a Multi-site Pilot Study of the OptiMed Clinical Trial NCT06688591 | HES-SO Valais-Wallis | N/A |
| Unknown | Pharmacogenomic Testing in a Program of All-inclusive Care for the Elderly (PACE) Setting NCT05053815 | Tabula Rasa HealthCare | — |
| Unknown | Spread and Scale of a Polypharmacy App NCT04762303 | Centre for Innovation and Research in Aging, Canada | N/A |
| Unknown | Pharmacological Optimization by a Specialized Outpatient Consultation Team NCT05408598 | Fundacion Miguel Servet | — |
| Completed | Aligning Medications With What Matters Most NCT04938648 | Johns Hopkins University | N/A |
| Completed | Deprescription of Gabapentinoids in Medical Inpatients NCT04855578 | McGill University Health Centre/Research Institute of the McGill University Health Centre | N/A |
| Completed | MIDAS Cluster Randomized Controlled Trial of Implementation Strategies to Optimize Use of Medications in VA Cl NCT05065502 | VA Office of Research and Development | N/A |
| Unknown | A Multidisciplinary Intervention Including a Clinical Decision Support System and an App for Drug Therapy Mana NCT04391218 | A.O.U. Città della Salute e della Scienza | N/A |
| Completed | Tailored Medication Management Intervention NCT04717297 | Washington University School of Medicine | N/A |
| Unknown | Polypharmacy and Associated Risk Factors and Clinical Outcomes for Surgical Patients Discharged From Hospital NCT04805151 | University of Iceland | — |
| Withdrawn | MedSafer E-care: an Automated Deprescribing Solution (E-CARE Study) NCT04087109 | McGill University Health Centre/Research Institute of the McGill University Health Centre | N/A |
| Completed | Psychological and Clinical Factors That Predict Intent to Deprescribe Medications Among Older Adults NCT04676282 | University of Michigan | — |
| Completed | Reducing Treatment Risk in Older Adults With Diabetes NCT04585191 | Kaiser Permanente | N/A |
| Unknown | Physician-initiated Medication Review in a Type 2 Diabetes Outpatient Clinic NCT05501223 | Bispebjerg Hospital | N/A |
| Completed | Development & Pilot of the Technology-Enabled Alliance for Medication Therapy Management NCT04575155 | Northwestern University | N/A |
| Completed | Bundled Hyperpolypharmacy Deprescribing NCT05616689 | Kaiser Permanente | N/A |
| Recruiting | Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine NCT04615065 | University Medical Center Groningen | — |
| Unknown | Malnutrition in Older Adults: An Intervention Based on Medication Review and Individual Nutritional Plan NCT04228900 | University of Oslo | N/A |
| Completed | Effect of Medication Management at Home Via Pharmacy Home Televisits NCT04340570 | VA Office of Research and Development | N/A |
| Unknown | A Pharmaceutical Intervention to Reduce Drug-Related Problems in a Home Healthcare Program NCT05820945 | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | N/A |
| Completed | MultiPAP Plus: Improving Prescription in Primary Care Patients With Multimorbidity and Polypharmacy NCT04147130 | Instituto Aragones de Ciencias de la Salud | N/A |
| Completed | Medication Monitoring for Older Adults in Primary Care NCT04663360 | Swansea University | N/A |
| Active Not Recruiting | Pharmacist Intervention to Reduce Post-Hospitalization Utilization NCT04071951 | Cedars-Sinai Medical Center | N/A |
| Completed | Reducing Costs by Deprescribing Medications NCT04553107 | The University of Texas Health Science Center, Houston | N/A |
| Active Not Recruiting | Effectiveness of PGx Testing NCT04120480 | Kaiser Permanente | N/A |
| Terminated | Team Approach to Polypharmacy Evaluation and Reduction in a Long-Term Care Setting NCT04055896 | McMaster University | N/A |
| Unknown | Appropriate Polypharmacy in Older People in Primary Care NCT04181879 | Queen's University, Belfast | N/A |
| Unknown | Deprescribing: a Portrait and Out-comes of the Reduction of Polypharmacy in Portugal NCT03283735 | University of Beira Interior | N/A |
| Suspended | Drug Interactions in Outpatients. NCT03943524 | University of Buenos Aires | N/A |
| Unknown | Team Approach to Polypharmacy Evaluation and Reduction (Pharmacy) NCT03557944 | McMaster University | N/A |
| Completed | Deprescribing in Primary Health Care NCT03903484 | Nova Scotia Health Authority | N/A |
| Completed | Evaluation of a Drug Interactions Software to Limit Polypharmacy NCT03901820 | University of Buenos Aires | N/A |
| Completed | Optimizing PharmacoTherapy In the Multimorbid Elderly in Primary CAre: the OPTICA Trial NCT03724539 | University of Bern | N/A |
| Completed | The Adverse Drug Reaction (ADRe) Profile for Polypharmacy NCT03955133 | Swansea University | N/A |
| Completed | Randomised, Controlled Trial of an Individual Deprescribing Intervention for Nursing Homes Residents NCT03655405 | Anne Niquille | N/A |
| Withdrawn | Rationalisation of Polypharmacy by the RASP-instrument and Discharge Counselling of Geriatric Inpatients NCT05816967 | Universitaire Ziekenhuizen KU Leuven | N/A |
| Unknown | Epidemiology of Polipharmacy and Potential Drug-Drug Interactions in Elderly Cardiac Outpatients NCT03370523 | Muğla Sıtkı Koçman University | — |
| Completed | Team Approach to Polypharmacy Evaluation and Reduction NCT02942927 | McMaster University | N/A |
| Completed | Feasibility Study of a Systematic Approach for Deprescribing of Statins and PPI's. NCT04204590 | Zuyderland Medisch Centrum | N/A |
| Unknown | Discontinuation of Long-term Medications in Older People Entering Nursing Home Care NCT03501108 | University College Cork | N/A |
| Enrolling By Invitation | SPIDER: A Research & QI Collaboration Supporting Practices in Improving Care for Complex Elderly Patients NCT03689049 | University of Toronto Practice Based Research Network | N/A |
| Completed | Application for an Electronic Medication Management Support System NCT03430336 | BARMER | N/A |
| Withdrawn | Structured Polypharmacy Management Before Elective Non-cardiac Surgery in Frail and Elderly People NCT03445767 | Ottawa Hospital Research Institute | N/A |
| Completed | Opportunities and Limits to Deprescribing in Nursing Homes:Quality Circle Deprescribing Module NCT03688542 | Anne Niquille | N/A |
| Completed | Elderly Appropriate Treatment in Primary Care (EAT) NCT03298386 | Assistance Publique - Hôpitaux de Paris | N/A |
| Terminated | Team Approach to Polypharmacy Reduction to Improve Mobility Long-Term Care NCT03202264 | McMaster University | — |
| Completed | Polypharmacy Outpatient Clinic NCT03911934 | Bispebjerg Hospital | N/A |
| Completed | Supporting Prescribing in Irish Primary Care: General Practice Pharmacist Study NCT04326062 | Royal College of Surgeons, Ireland | N/A |
| Unknown | Nutritional Status and Medication Treatment in Home-dwelling Older Adults NCT04229238 | University of Oslo | — |
| Completed | Deprescribing in a Long Term Care Facility NCT03091153 | Memorial University of Newfoundland | N/A |
| Completed | A Randomized Controlled Trial to Deprescribe for Older Patients With Polypharmacy NCT02979353 | Vanderbilt University Medical Center | N/A |
| Completed | Multi-PAP: Improving Prescription in Primary Care Patients With Multimorbidity and Polypharmacy NCT02866799 | Instituto Aragones de Ciencias de la Salud | N/A |
| Unknown | Biological Aging, Medication, Malnutrition and Inflammation Among Acutely Ill and Healthy Elderly. NCT03052192 | Hvidovre University Hospital | — |
| Completed | Reducing Post-discharge Potentially Inappropriate Medications Among Older Adults NCT02918058 | McGill University Health Centre/Research Institute of the McGill University Health Centre | N/A |
| Completed | Effectiveness of a Medication Wallet Card NCT02820129 | McMaster University | Phase 1 |
| Completed | Longitudinal Analysis of Drug Burden Index NCT03024541 | University of Groningen | — |
| Unknown | Deprescribing of Symptomatic Medications in Rehabilitative or Subacute Care Patients NCT03354845 | Bright Vision Hospital | N/A |
| Unknown | Oncogeriatric Intervention and Follow-up at Home NCT02837679 | Aarhus University Hospital | N/A |
| Completed | Development of a Coordinated, Community-Based Medication Management Model for Home-Dwelling Aged in Primary Ca NCT02545257 | University of Helsinki | N/A |
| Unknown | The Interprofessional Medication Assessment for Older Patients NCT02398812 | East Savo Hospital District | N/A |
| Completed | DBI - Tool for Medication Reviews in Older People NCT02317666 | University of Groningen | N/A |
| Completed | Risk Factors for Polypharmacy in Older Adults NCT03524560 | Karabuk University | — |
| Completed | Care Planning for Older Persons With Multiple Conditions: Encouraging a Tailored Approach (COMET): Stage II NCT02501967 | Yale University | N/A |
| Withdrawn | Measuring the Impact of an Interdisciplinary Polypharmacy Clinic Within a Patient-centered Medical Home NCT02077725 | Ohio State University | — |
| Withdrawn | Medication Minimization for Long-term Care Residents NCT01932632 | University of British Columbia | N/A |
| Completed | Educational Intervention to Reduce Drug-related Hospitalizations in Elderly Primary Health Care Patients NCT01732302 | Karolinska Institutet | N/A |
| Completed | Polymedication Check - a Randomised Controlled Trial NCT01739816 | Kurt Hersberger | N/A |
| Completed | Clinical and Economical Assessment of an Intervention to Reduce Potentially Inappropriate Medication in Polyme NCT02275572 | Consorci Sanitari del Maresme | N/A |
| Unknown | Treatment of Salivary Gland Hypofunction With Neuro- Electrostimulation NCT01174329 | Universidad Autonoma de Nuevo Leon | Phase 2 / Phase 3 |
| Terminated | An Intervention Study to Reduce the Use and Impact of Potentially Inappropriate Medications Among Older Adults NCT01148186 | Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal | Phase 4 |
| Completed | Improving Compliance Among Elderly Polypharmacy Users Through Community Pharmacy Based Pharmaceutical Care Pro NCT00916214 | Ringkobing Love Apotek | Phase 2 |
| Completed | Polypharmacy and Outcomes After Elective Noncardiac Surgery NCT03133182 | Ottawa Hospital Research Institute | — |