| Recruiting | Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors NCT07443020 | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | Phase 1 |
| Recruiting | Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease NCT07192900 | David Bartlett, MD | Phase 1 |
| Not Yet Recruiting | Comparison of Talc Slurry Versus Talc Insufflation: A Study on Effectiveness, Safety, and Hospital Outcomes in NCT07167992 | University of Health Sciences Lahore | N/A |
| Not Yet Recruiting | Pleurodesis in Small-bore Chest Tube NCT07208409 | The University of Hong Kong | N/A |
| Completed | PMCF Study of the CE-marked Drainova® ArgentiC Catheter NCT06436807 | ewimed GmbH | — |
| Unknown | Medical Thoracoscopy for Diagnosing Unexplained Pleural Effusion: a National Multicenter Retrospective Study NCT06275178 | China-Japan Friendship Hospital | — |
| Not Yet Recruiting | Cancer Ratio,Pleural Fluid Adenosine Deaminase,Lactate Dehydrogenase, interferonY, Tumor Necrosis Factor,and I NCT05693727 | Assiut University | — |
| Recruiting | First Local Anaesthesia Thoracoscopy for Pleural Effusion Diagnosis. NCT06946498 | National and Kapodistrian University of Athens | N/A |
| Recruiting | Clinical Study on Intraluminal Injection of FOLactis NCT06512896 | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | N/A |
| Recruiting | IFN-γ Combined With T Cells in the Treatment of Refractory Malignant Pleural Effusion and Ascites NCT05268172 | Affiliated Hospital of Jiangnan University | Phase 1 |
| Recruiting | Pleural Carcinomatosis Tissue Banking NCT04844827 | Hospices Civils de Lyon | — |
| Completed | Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx) NCT05461430 | Travera Inc | — |
| Unknown | Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including NCT05278975 | RS Oncology LLC | Phase 1 / Phase 2 |
| Recruiting | Dual-targeting HER2 and PD-L1 CAR-T for Solid Tumors NCT04684459 | Sichuan University | EARLY_Phase 1 |
| Unknown | Longitudinal Follow up of Patients With Pleural Effusion NCT04670562 | Seoul National University Bundang Hospital | — |
| Terminated | Comparing Different Sizes of Small-bore Chest Drains in Malignant Pleural Effusion NCT04669223 | The University of Hong Kong | N/A |
| Unknown | Prospective Data Collection on Clinical, Radiological and Patient Reported Outcomes After Pleural Intervention NCT05910112 | University of Oxford | — |
| Completed | Intrapleural Instillation of the Nivolumab in Cancer Patients With Pleural Effusion. NCT04749602 | Kidney Cancer Research Bureau | Phase 2 |
| Unknown | Use of Guidance Videos to Increase Engagement and Decrease Anxiety in Patients Undergoing Pleural Tap NCT04254445 | GistMed Ltd. | N/A |
| Unknown | A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia NCT05077111 | Mohamed Reda Ashour | Phase 4 |
| Terminated | A Randomised Study Evaluating Diagnostics of Pleural Effusion Among Patients Suspect of Cancer. NCT04233359 | Naestved Hospital | N/A |
| Unknown | Management of Malignant Pleural Effusion With Indwelling Pleural Catheter Versus Silver Nitrate Pleurodesis NCT03781908 | Assiut University | Phase 1 / Phase 2 |
| Completed | Respiratory Function of Dexmedetomidine in Patients Undergoing Pleuroscopy NCT03597828 | Attikon Hospital | — |
| Terminated | Rapid Pleurodesis Through an Indwelling Pleural Catheter NCT03325192 | University of Pennsylvania | N/A |
| Completed | The Value of PET-CT in Pleural Effusions NCT03272997 | Naestved Hospital | — |
| Completed | The Added Value of CT Scanning in Patients With an Unilateral Pleural Effusion NCT03270215 | Naestved Hospital | — |
| Unknown | EDIT Management Feasibility Trial NCT03319186 | NHS Greater Glasgow and Clyde | N/A |
| Unknown | Management of Malignant Pleural Effusion - Indwelling Pleural Catheter or Talc Pleurodesis NCT02825095 | Rambam Health Care Campus | EARLY_Phase 1 |
| Completed | Intrapleural Docetaxel Administration Using Medical Pleuroscopy in Malignant Effusion With Lung Cancer NCT03394105 | Asan Medical Center | Phase 2 |
| Completed | Prognostic Factors on Malignant Pleural Effusion NCT03276715 | The University of Hong Kong | — |
| Unknown | Manometry vs Clinical Assessment in the Detection of Trapped Lung in Patients With Suspected Pleural Malignanc NCT02805062 | NHS Greater Glasgow and Clyde | — |
| Terminated | Photo-induction as a Means to Improve Cisplatin Delivery to Pleural Malignancies NCT02702700 | Centre Hospitalier Universitaire Vaudois | Phase 1 |
| Completed | Out Patient Talc Slurry Via Indwelling Pleural Catheter for Malignant Pleural Effusion Vs Usual Inpatient Mana NCT02517749 | Guy's and St Thomas' NHS Foundation Trust | N/A |
| Unknown | Cisplatin for Malignant Pleural Effusion in Patients With Non-small-cell Lung Cancer NCT02407912 | Shantou University Medical College | N/A |
| Terminated | Intrapleural Bevacizumab After Pleural Drainage in the Context of Breast Cancer NCT02250118 | Institut Curie | Phase 1 |
| Terminated | The Effect of Non-Steroidal Anti-Inflammatory Drug Naproxen on Pleural Effusion Formation After Lung Resection NCT01612975 | McMaster University | Phase 2 |
| Unknown | Multicentre Study Comparing Indwelling Pleural Catheter With Talc Pleurodesis for Malignant Pleural Effusion M NCT02045121 | National University Hospital, Singapore | N/A |
| Unknown | Relationship Between Pleural Elastance and Effectiveness of Pleurodesis on Recurrent Malignant Pleural Effusio NCT01819363 | Grupo de Pesquisa em Pleura e Oncologia Toracica | — |
| Completed | Safety Profile of Iodopovidone as an Agent for Pleurodesis in Malignant Pleural Effusion NCT01670786 | Grupo de Pesquisa em Pleura e Oncologia Toracica | Phase 4 |
| Completed | Impact of Aggressive Versus Standard Drainage Regimen Using a Long Term Indwelling Pleural Catheter NCT00978939 | Duke University | Phase 4 |
| Terminated | Multiple Biomarkers in Undiagnosed Pleural Effusion NCT00316134 | Fujirebio Diagnostics, Inc. | — |
| Completed | Non-small Cell Lung Cancer Registry NCT00099541 | Novartis Pharmaceuticals | Phase 4 |