| Not Yet Recruiting | Intraoperative Wound Irrigation for Pilonidal Disease NCT07417202 | Stanford University | N/A |
| Recruiting | Effect of Antiseptic Irrigations With 0.05% Chlorhexidine Gluconate (Irrisept) Versus Normal Saline on Fascioc NCT07321704 | Yosef Nasseri, MD | N/A |
| Recruiting | Pilot Trial Assessing the Effectiveness of Laser Hair Depilation on Pilonidal Disease Recurrence in Patients W NCT06406621 | Nemours Children's Clinic | N/A |
| Recruiting | Topical Anti-Androgens in Pilonidal Sinus Disease NCT06286397 | University of Pennsylvania | Phase 2 |
| Completed | Pain Control for Laser Epilation in Pilonidal Disease NCT06640946 | David Mooney | Phase 4 |
| Not Yet Recruiting | Comparing Minimally Invasive Treatments for Pilonidal Disease: LA POPA Trial (Laser And Pit-picking OR Pit-pic NCT06140199 | dr. IJM Han-Geurts | N/A |
| Recruiting | The Role of Mesenchymal Stem Cell and Exosome in Treating Pilonidal Sinus Disease in Children NCT06391307 | Mustafa Azizoğlu | N/A |
| Enrolling By Invitation | A Trial in Mini-invasive Pilonidal Sinus Disease Surgery NCT06964763 | Helsinki University Central Hospital | N/A |
| Unknown | Injection of Freshly Collected Autologous Adipose Tissue Additional to Bascom's Cleft Lift Surgery NCT05830734 | University of Aarhus | N/A |
| Unknown | Comparison of Laser Destruction of Pilonidal Sinus Disease (SILAC) and Bascom II Procedure. NCT05715983 | Russian Society of Colorectal Surgeons | N/A |
| Recruiting | Comparing Operative vs Non Operative Treatment for Pilonidal Disease NCT05439291 | Stanford University | N/A |
| Completed | Unroofing Curettage for Pilonidal Disease NCT05339828 | Ankara Diskapi Training and Research Hospital | — |
| Completed | Effect of Platelet Rich Plasma (PRP) on Healing Time in Patients Following Pilonidal Sinus Surgery NCT06206330 | İsmail Oskay Kaya | N/A |
| Completed | Clinical Trial to Test the Phenolization in Sacrococcygeal Pilonidal Disease NCT05404243 | HJ23 | Phase 4 |
| Completed | Surgical Approach for Pilonidal Disease NCT04334681 | Konya Meram State Hospital | — |
| Terminated | The Management of Pilonidal Wounds With ACell MicroMatrix® and Cytal® Wound Matrix: A Case Series NCT04041037 | Integra LifeSciences Corporation | — |
| Completed | Laser Hair Removal for Treatment of Pilonidal Disease NCT03949140 | University of Wisconsin, Madison | N/A |
| Terminated | Randomized Trial Comparing Prevena and ActiV.A.C. System to Convetional Care After Bascom's Cleft Lift Surgery NCT03458663 | University of Aarhus | N/A |
| Active Not Recruiting | MIPE for Pilonidal Disease NCT03772873 | Northwell Health | — |
| Terminated | Excision and Reconstruction of the Natal Cleft With a Parasacral Perforator Flap Versus Open Excision With Sec NCT03534700 | University Hospital, Toulouse | N/A |
| Unknown | Non-Powered Negative Pressure Wound Therapy vs Open Technique for Pilonidal Disease NCT03483480 | The National Children's Hospital, Tallaght | N/A |
| Unknown | De-roofing and Curettage vs WLE for Pilonidal Abscess NCT03415347 | London North West Healthcare NHS Trust | N/A |
| Completed | Application of Platelet-rich Plasma in Pilonidal Sinus Disease NCT04697082 | Cihangir Akyol | N/A |
| Completed | Debridement and Laser Ablation Versus Debridement Alone in Pilonidal Disease NCT05569135 | Istanbul Medipol University Hospital | — |
| Unknown | Effectiveness of Laser Hair Removal in Pilonidal Disease NCT03276065 | Nationwide Children's Hospital | N/A |
| Completed | Pilot Study of Laser Hair Depilation for Pilonidal Disease NCT02778152 | Peter Minneci | N/A |
| Unknown | Feasibility of a Novel Technique for Pilonidal Wound Healing NCT02330159 | Southeast Clinical Research Associates, Houston, Texas | — |
| Unknown | Pilonidal Disease Wound Healing Study NCT01857128 | Walter Reed National Military Medical Center | Phase 4 |
| Completed | Comparison of Tension Free Primary Closure, Karydaks and Limberg Flap Methods NCT02186964 | Konya Meram State Hospital | N/A |
| Withdrawn | Open Wide Excision Versus Minimal Surgery for Pilonidal Disease NCT01241136 | United States Naval Medical Center, Portsmouth | N/A |
| Completed | Comparison Between Two Different Technique in Treatment of Chronic Pilonidal Disease NCT01268969 | Mansoura University | N/A |