| Not Yet Recruiting | Mineral Trioxide Aggregate (MTA) vs Gutta-Percha for Non-Surgical Endodontic Retreatment in Teeth With Apical NCT07477171 | University of Santiago de Compostela | N/A |
| Recruiting | Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment NCT07448571 | Marmara University | N/A |
| Completed | The Effect of Different Hemostatic Agents on Hemorrhage Control, Pain and Quality of Life After Endodontic Mic NCT07311291 | University of Turin, Italy | N/A |
| Not Yet Recruiting | Postoperative Pain in Photodynamic Therapy Using Curcumin As a Photosensitizer NCT06752655 | Ataturk University | N/A |
| Completed | Effect of Targeted Endodontic Microsurgery on Quality of Life and Healing on Mandibular Molars NCT06643676 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Recruiting | Role of GTR on Healing Outcome & Quality of Life in Combined Endo Perio Lesions With Communication NCT06643663 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Completed | Postoperative Pain After Conservative Root Canal Preparation NCT06545773 | Istanbul University | N/A |
| Completed | The Use of Artificial Intelligence in the Dental X-rays Analysis NCT06258798 | Hospital of the Ministry of Interior, Kielce, Poland | — |
| Unknown | Microbial Load After Apical Enlargement in Asymptomatic Teeth With Periapical Lesion NCT06035185 | Istanbul Medipol University Hospital | — |
| Completed | Effect of Aloe Vera Gel as an Intra Canal Medicament NCT06243601 | Islamabad Medical and Dental College | N/A |
| Completed | PRF Membrane and Recovery After Periapical Surgery: A 3D Imaging Study NCT06739200 | Semmelweis University | N/A |
| Enrolling By Invitation | Clinical Efficacy of AH Plus Bioceramic Sealer NCT05763420 | Ministry of Health, Kuwait | N/A |
| Unknown | Effectiveness of Photodynamic Therapy in the Disinfection of Root Canals in Patients With Apical Lesion NCT05916859 | Universidad de La Frontera | N/A |
| Enrolling By Invitation | Calcium Silicate Sealer-based Obturation in Root Canal Retreatment NCT05714384 | Ministry of Health, Kuwait | — |
| Unknown | Cell-free Autologous Regenerative Endodontics Treatment for Teeth With Periapical Lesions (CARETT) NCT05305417 | Universidad de Valparaiso | N/A |
| Active Not Recruiting | Survival and Success of Two Different Filling Techniques NCT06252337 | University of Bologna | N/A |
| Completed | Comparison of Clinical Outcomes Between GentleWave® and Biolase® NCT05555043 | University of North Carolina, Chapel Hill | N/A |
| Recruiting | Detection of Periapical Lesions on Dental Panoramic Radiographs Based on Artificial Intelligence NCT05888935 | Centre Hospitalier Régional Metz-Thionville | — |
| Unknown | Evaluation of RANKL/OPG Levels in Gingival Crevicular Fluid at 1st and 3rd Months of Activation of NaOCl With NCT05478811 | Yuzuncu Yil University | N/A |
| Completed | Effect of EDDY Sonic Irrigation on Root Canal Microbiota and Pain in Asymptomatic Apical Periodontitis NCT07120126 | Abdulkadir Tiftik,DDS | N/A |
| Completed | Post-Operative Evaluation of Endodontic Microsurgeries Done Using a Piezoelectric Ultrasonic Technique: An in NCT05863728 | Al-Azhar University | N/A |
| Completed | The Impact of Root End Filling Material Type and the Application of Bone Graft on Healing of Periapical Tissue NCT05943769 | Ain Shams University | N/A |
| Completed | Effect of MTAD on The Outcome of Primary Root Canal Treatment NCT05555563 | Cukurova University | N/A |
| Completed | Impact of Periapical Radiography and Cone Beam Computed Tomography on Periapical Assessment Following Surgical NCT04333940 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Completed | Comparing Efficacy of a Stainless-steel Rotary File with Two Nickel-titanium Systems on Periapical Lesion Heal NCT06752837 | Beirut Arab University | N/A |
| Completed | Efficiency of Diode Laser in Control of Post-endodontic Pain NCT04315259 | Ain Shams University | N/A |
| Completed | Efficiency of Soft Tissue Diode Laser Application on Healing of Periapical Tissues NCT04311879 | Ain Shams University | N/A |
| Completed | Efficiency of Diode Laser Activated Irrigation on Healing of Periapical Tissues NCT04311905 | Ain Shams University | N/A |
| Completed | Apicoectomy Longterm Results NCT03108183 | Medical University of Graz | — |
| Completed | Effect of QMix 2in1 as Final Irrigation Protocol on Periapical Healing NCT04348578 | Cukurova University | N/A |
| Unknown | Research of the Application of Triple Antibiotic Paste in Primary Teeth With Pericpical Periodontitis NCT02196740 | Lin Jiacheng | N/A |
| Completed | Differential Diagnosis Between Granuloma and Radicular Cyst: Effectiveness of Magnetic Resonance Imaging. NCT03227172 | University of Bologna | — |
| Completed | Use of Mineral Trioxide Aggregate in the Treatment of Traumatized Teeth NCT02625298 | Association of Paediatric and Preventive Dentists of Serbia | Phase 2 |
| Completed | Retreat or Replace: Retrospective Investigation on a Cohort of Local Patients NCT06250114 | University of Bologna | — |