| Not Yet Recruiting | Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions NCT06876038 | University of Massachusetts, Boston | Phase 2 |
| Recruiting | Dual-energy CT vs. MRI in the Evaluation of Squamous Cell Carcinomas of the Oral Cavity and Oropharynx NCT07343271 | University Hospital, Strasbourg, France | — |
| Recruiting | A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Canc NCT07063212 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Recruiting | Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer NCT06627270 | Case Comprehensive Cancer Center | Phase 2 |
| Recruiting | People Living With HIV, Oral and Oropharyngeal Cancer, and Health Equity NCT06055868 | University of California, San Francisco | — |
| Recruiting | Validity of Viome's Oral/throat Cancer Test NCT06174428 | Viome | — |
| Recruiting | Safety and Efficacy Study of PRV111 and PRV211 in Subjects With Oral Squamous Cell Carcinoma NCT05893888 | Privo Technologies | Phase 2 / Phase 3 |
| Not Yet Recruiting | NBI for Early Diagnosis of OPMD/OSCC NCT06438939 | Cardarelli Hospital | N/A |
| Recruiting | SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomograph NCT06321003 | University of Palermo | — |
| Recruiting | Neoadjuvant Immunochemotherapy for LAOSCC NCT06258811 | Lai-ping Zhong | Phase 3 |
| Unknown | A Prospective, Single-arm Phase II Clinical Trial of Tislelizumab Combined With Platinum Doublet Neoadjuvant T NCT06130007 | Xuekui Liu | Phase 2 |
| Recruiting | Neoadjuvant Anti-PD-1 Immunotherapy With Chemotherapy in Resectable Locally Advanced Oral Squamous Cell Carcin NCT05798793 | Hospital of Stomatology, Wuhan University | Phase 3 |
| Completed | Salivary Expression of SOX7 in Oral Squamous Cell Carcinoma: Diagnostic Accuracy Study NCT06031337 | Fayoum University | — |
| Unknown | WORST PATTERN OF INVASION IN ORAL SQUAMOUS CELL CARCINOMA NCT05927220 | Armed Forces Institute of Pathology Rawalpindi | — |
| Active Not Recruiting | Neoadjuvant Tislelizumab Plus Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer (NeoSPOT) NCT06009861 | Peking University Hospital of Stomatology | Phase 2 |
| Terminated | A Study of Vobramitamab Duocarmazine in Participants With Metastatic Castration Resistant Prostate Cancer and NCT05551117 | MacroGenics | Phase 2 |
| Recruiting | Neoadjuvant Treatment of Tislelizumab Combined Chemotherapy for Locally Advanced Oral Squamous Cell Carcinoma NCT05862168 | Weijia Fang, MD | Phase 2 |
| Unknown | Neoadjuvant Toripalimab Plus Nimotuzumab in Oral Squamous Cell Carcinoma Prior to Radical Therapy NCT05803915 | Peking Union Medical College Hospital | Phase 2 |
| Not Yet Recruiting | Elective vs Therapeutic Neck Dissection in Treatment of Patients With Clinical T1/2N1M0 Oral Squamous Cell Car NCT05806073 | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | N/A |
| Recruiting | Tolerance and Benefits of Mandibular Advanced Device for Snoring and Sleep Apnea in Oropharyngeal Cancer. NCT05719779 | Centre hospitalier de l'Université de Montréal (CHUM) | N/A |
| Completed | The Long Non Coding MALAT1 as a Potential Salivary Diagnostic Biomarker in Oral Squamous Cell Carcinoma Throug NCT05708209 | Fayoum University | — |
| Completed | Postoperative Radiotherapy for Oral Squamous Cell Carcinoma After Neoadjuvant Therapy and Surgery NCT05455632 | Shanghai Jiao Tong University School of Medicine | — |
| Recruiting | Detection of Oral and Throat Cancers Using OralViome Cancer Testing System NCT05451303 | Viome | — |
| Completed | Neoadjuvant Imiquimod Immunotherapy for Oral Cancer NCT04883645 | Medical University of South Carolina | EARLY_Phase 1 |
| Recruiting | TPExtreme Induced Chemotherapy Followed by Surgery and Radiotherapy in the Oral Carcinoma. NCT05872880 | Xiangya Hospital of Central South University | — |
| Unknown | Epigenetic Biomarkers in the Saliva for the Diagnosis of Squamous Cells Carcinoma of the Oral Cavity NCT05791149 | Centre Hospitalier Universitaire, Amiens | N/A |
| Completed | Salivary LINC00657 as a Diagnostic Biomarker for Oral Squamous Cell Carcinoma NCT05821179 | Fayoum University | — |
| Unknown | Oral Microbioma and Oral Malignant Disease NCT05766150 | Academisch Ziekenhuis Maastricht | — |
| Recruiting | Neoadjuvant Anti-PD-1 and TP Versus TPF on Pathological Response in OSCC NCT05125055 | Shanghai Jiao Tong University School of Medicine | Phase 2 / Phase 3 |
| Unknown | Dissecting the Heterogeneity of Oral Cancer Pain NCT05024383 | NYU College of Dentistry | N/A |
| Recruiting | Neoadjuvant Sintilimab Combined With Reduction of Cycles of Chemotherapy in Resectable Oral Cavity or Orophary NCT05098119 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Phase 2 |
| Recruiting | Neoadjuvant Personalized Anti-PD-1 and Anti-VEGFR Therapy in OSCC Patients NCT05069857 | Shanghai Jiao Tong University School of Medicine | Phase 2 |
| Unknown | Using Vitamin D to Reduce Oral Mucosal Inflammation in Chemotherapy Patients With Oral Squamous Cell Carcinoma NCT06016400 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Phase 2 / Phase 3 |
| Unknown | Differential Mobility Spectrometry (DMS) Based Oral Tumor Analysis NCT05902455 | Tampere University Hospital | — |
| Completed | Neoadjuvant PD-1 Blockade in Resectable Oral Squamous Cell Carcinoma NCT04649476 | Hospital of Stomatology, Wuhan University | Phase 2 |
| Active Not Recruiting | Neoadjuvant Sintilimab in Combination With Carboplatin and Nab-paclitaxel in Resectable Oral Cavity or Orophar NCT04718415 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Phase 2 |
| Unknown | Association of Salivary Amino Acid Level With OSCC Identified By Liquid Chromatography Mass Spectroscopy NCT05150509 | DR. MALA KHAN | — |
| Unknown | Predicting Metastatic Oral Squamous Cell Carcinomas With Molecular Biomarkers Using Machine Learning NCT04543266 | The University of Hong Kong | — |
| Unknown | A Study of TC(Docetaxel and Carboplatin) Regimen With or Without Nimotuzumab in Recurrent Metastatic Oral Squa NCT04367909 | Xin-Hua Xu | Phase 2 |
| Unknown | Camrelizumab Plus Docetaxel and Cisplatin in Recurrent or Metastatic Oral Squamous Cell Carcinoma Patients NCT05611463 | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | Phase 2 |
| Completed | Carrimycin in Patients With Locally Advanced, Recurrent, or Metastatic HNSCC (Non NPC): A Phase I Trial NCT04413214 | Shanghai Jiao Tong University School of Medicine | Phase 1 |
| Unknown | Assessment of Anti-cancerous Effect of Green, Roasted and Decaffeinated Coffee on Oral Squamous Cell Carcinoma NCT03619304 | Cairo University | N/A |
| Completed | Toluidine Blue Versus Frozen Sections for Assessment of Tumor Margins in Oral Squamous Cell Carcinoma NCT03554967 | Cairo University | — |
| Completed | Safety and Efficacy Study of PRV111 in Subjects With Oral Squamous Cell Carcinoma NCT03502148 | Privo Technologies | Phase 1 / Phase 2 |
| Recruiting | "Ultra-High Frequency intraOral UltraSonography of the TONgue" (HOUSTON) NCT06336941 | University of Pisa | N/A |
| Unknown | The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related NCT03418454 | Barzilai Medical Center | — |
| Unknown | Assessment of Bmi-1 on Protein and Molecular Levels in Oral Dysplasia and Squamous Cell Carcinoma: A Diagnosti NCT03345966 | Cairo University | N/A |
| Completed | Melatonin Effect in Combination With Neoadjuvant Chemotherapy to Clinical Response in Locally Advanced Oral Sq NCT04137627 | Indonesia University | Phase 3 |
| Unknown | Effect of COX-2 and EGFR Suppression on Molecular Markers of Angiogenesis and Proliferation in Squamous Cell C NCT02748707 | Tata Memorial Hospital | Phase 2 |
| Unknown | Concurrent Radiotherapy and/or Cisplatin With or Without Celecoxib in Patients With Primary Oral Squamous Cell NCT02739204 | China Medical University Hospital | Phase 2 |
| Unknown | Comparison of Morphometric Assessment Using Methyl Green Pyronin and AgNOR Staining of Oral Squamous Cell Carc NCT01987934 | Academy of Interdisciplinary Dental Education and Research | — |
| Unknown | Developing an In-vitro Diagnostic Risk-Stratification Test for Oral Cancer NCT01587573 | PeriRx | — |
| Unknown | Survival Benefit of Elective Neck Dissection in T1,2N0M0 Oral Squamous Cell Carcinoma NCT01334320 | Sun Yat-sen University | N/A |
| Completed | Verification of Saliva MMP-1 as a Diagnostic Marker of Oral Cavity Cancer NCT05049408 | S&T Biomed Co., Ltd. | — |
| Completed | Molecular Mechanisms of the Development of Precancerous and Cancerous Lesions of the Oral Cavity NCT03026361 | University of Zagreb | — |
| Unknown | Laser Mucite ORL : Effectiveness of Laser Therapy for Mucositis Induced by a Radio-chemotherapy in Head and Ne NCT01772706 | Institut Cancerologie de l'Ouest | N/A |