| Recruiting | Ultrasonographic Assessment of Muscle Morphology, Function, and Clinical Findings in Spastic Cerebral Palsy NCT07118228 | Kocaeli University | — |
| Recruiting | SIRS-ESWT Trial: Shoulder Internal Rotator Spasticity Trial Treated With Extracorporeal Shock Wave Therapy Tri NCT06674785 | National Taiwan University Hospital | N/A |
| Recruiting | Effect of Diving and Aquatic Exercises on Muscle Spasticity and Motor Function in Children With Spastic Cerebr NCT06902168 | Benha University | N/A |
| Recruiting | Comparing Upper Limb Surgery and Botulinum Toxin for Spasticity: A Paired Design Study NCT06733025 | Vastra Gotaland Region | N/A |
| Completed | Effectiveness of Whole-Body Vibration NCT06330311 | Universidad Complutense de Madrid | N/A |
| Completed | Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals NCT06117020 | Motric Bio | Phase 1 |
| Recruiting | Therapeutic Photobiomodulation and Tretament of Spasticity NCT06536751 | University of Nove de Julho | Phase 2 / Phase 3 |
| Terminated | The Decline in Walking Performance in Adults With Cerebral Palsy - Influence of Performance Fatigability NCT06163950 | Centre Hospitalier Universitaire de Saint Etienne | N/A |
| Completed | "Comparison of Therapist-Led and Robot-Assisted Arm Therapy in Subacute Stroke Rehabilitation" NCT07002463 | Wroclaw University of Health and Sport Sciences | N/A |
| Completed | A Study to Collect Participants Experience of Living With Adult Upper Limb (AUL) Spasticity and to Assess the NCT05546190 | Ipsen | — |
| Completed | Quantitative Evaluation of Muscle Stiffness in Neurological Patients With Muscle Overactivity NCT05510726 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | — |
| Completed | Comparison of Two Botox Injection Techniques to Improve Gait NCT07124806 | Universidad de los Andes, Chile | N/A |
| Terminated | Study Evaluating MyoRegulator® Treatment in Post-Stroke Upper Limb Spasticity NCT04742257 | PathMaker Neurosystems Inc. | N/A |
| Active Not Recruiting | Peripheral Modulation of Muscle Stiffness and Spasticity NCT03306615 | Johns Hopkins University | Phase 2 |
| Completed | Effects of Repeated Botulinum Toxin Injections in Children With Cerebral Palsy NCT05295563 | Gazi University | — |
| Active Not Recruiting | H-reflex in Spastic Lower Limb Cryoneurotomy NCT04907201 | Vancouver Island Health Authority | — |
| Recruiting | Upper-limb Active Function and Botulinum Toxin a NCT03783572 | University Hospital, Toulouse | N/A |
| Unknown | Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS) NCT04530955 | Culicchia Neurological Clinic | N/A |
| Active Not Recruiting | Dry Needling for Spasticity in Stroke NCT04535479 | Medical University of South Carolina | N/A |
| Unknown | Error Augmentation Motor Learning Training Approach in Stroke Patients NCT04378946 | McGill University | N/A |
| Completed | The Effect of Extracorporeal Shock Wave Therapy After Botulinum Toxin Type A Injection for Post-stroke Spastic NCT05889026 | Korea University Guro Hospital | N/A |
| Terminated | Measurements of Displacement Amplitude and Angular Velocities During Passive Extension of the Wrist and Hand C NCT04502927 | Groupe Hospitalier de la Region de Mulhouse et Sud Alsace | N/A |
| Completed | Tele-physiotherapy on Post-stroke Hemiplegia Patients NCT06048432 | Universidad Católica San Antonio de Murcia | N/A |
| Unknown | Hemodynamic Changes During Dry Cupping Therapy on Low Back Pain NCT03816787 | Chinese Academy of Medical Sciences | N/A |
| Completed | Effect of Cervical Mobilization on Balance and Plantar Pressure Distribution in Multiple Sclerosis NCT04543448 | Hasan Kalyoncu University | N/A |
| Completed | The Effect of Whole Body Vibration (WBV) on Spasticity in Poststroke Hemiplegia NCT03916770 | Istanbul Physical Medicine Rehabilitation Training and Research Hospital | N/A |
| Completed | Muscle Selection for Botulinum Toxin A Injection in Poststroke Elbow Flexor Spasticity NCT04036981 | Izmir Katip Celebi University | — |
| Completed | Stroke and Assessment of Muscle Tone NCT03814460 | University of Seville | — |
| Unknown | Randomized Controlled Trial of Virtual Reality NCT03521076 | Gillette Children's Specialty Healthcare | N/A |
| Completed | Investigation of Treatment Using the MyoRegulator® Device in Patients With Spasticity in the Lower Limb Due to NCT04780191 | Institut National de la Santé Et de la Recherche Médicale, France | N/A |
| Terminated | The Movement of Botulinum Toxin Through the Lateral Gastrocnemius Muscle in Humans: An Expanded Examination NCT03367429 | Weill Medical College of Cornell University | Phase 4 |
| Completed | Validity and Inter-Rater Reliability of a Novel Bedside Referral Tool for Spasticity NCT03209960 | Vanderbilt University Medical Center | — |
| Completed | Using Telemedicine to Improve Spasticity Diagnosis Rates NCT03211390 | Vanderbilt University Medical Center | — |
| Completed | Prevalence of Comorbid Spasticity and Urinary Incontinence in Residents of a Long-Term Care Facility NCT03250988 | Vanderbilt University Medical Center | — |
| Active Not Recruiting | Reliability of Cardiac Troponins for the Diagnosis of Myocardial Infarction in the Presence of Skeletal Muscle NCT03660969 | University Hospital, Basel, Switzerland | — |
| Completed | CORETOX® in Treatment of Post Stroke Upper Limb Spasticity (Phase3) NCT03289702 | Medy-Tox | Phase 3 |
| Completed | CORETOX® in Treatment of Post Stroke Upper Limb Spasticity (Phase1) NCT05164003 | Medy-Tox | Phase 1 |
| Recruiting | Exoskeleton and Spinal Cord Stimulation for SCI NCT03096197 | Kessler Foundation | N/A |
| Completed | Multi-channel Stimulation for Post Stroke Spasticity (MUSTS) NCT02907775 | Sheffield Teaching Hospitals NHS Foundation Trust | N/A |
| Completed | The Role of Trans-spinal Direct Current Stimulation (tsDCS) in Treating Patients With Hand Spasticity After St NCT03080454 | Northwell Health | Phase 1 / Phase 2 |
| Completed | Meditoxin® Treatment in Patients With Post Stroke Upper Limb Spasticity NCT02757404 | Medy-Tox | Phase 4 |
| Completed | Effects of Soft Tissue Lengthening on Gait in Children With Spasticity NCT04090892 | University of Texas Southwestern Medical Center | — |
| Completed | Intrathecal (IT) Baclofen Drug Distribution NCT02903823 | Vanderbilt University | Phase 4 |
| Unknown | Effects of Cryotherapy on Ankle Movements and Gait of Spastic Hemiparetic Subjects NCT02736747 | Carolina Carmona de Alcântara | N/A |
| Completed | Altering Activation Patterns Post-stroke NCT02418949 | Shirley Ryan AbilityLab | N/A |
| Completed | Does Botulinum Toxin A Make Walking Easier in Children With Cerebral Palsy? NCT02546999 | St. Olavs Hospital | Phase 4 |
| Unknown | Effects of Functional Electrical Stimulation on Gait in Children With Cerebral Palsy NCT02462018 | Tel-Aviv Sourasky Medical Center | Phase 4 |
| Completed | Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment NCT02462317 | University Hospital, Toulouse | Phase 4 |
| Completed | Muscle Ultrasound Measures as Biomarkers of Upper Motor Neuron Function NCT02408900 | National Institute of Neurological Disorders and Stroke (NINDS) | — |
| Withdrawn | Long-Term Study of OnabotulinumtoxinA Treatment in Adult Patients With Upper Limb Spasticity NCT02145689 | Allergan | Phase 3 |
| Completed | Powered Exoskeleton for the Treatment of Elbow Spasticity NCT02934646 | Auxilium Vitae Volterra | Phase 2 |
| Withdrawn | Spasticity Registry Evaluating Epidemiology, Treatment Patterns and Clinical Needs NCT02145650 | Allergan | — |
| Terminated | OnabotulinumtoxinA Treatment in Adult Patients With Upper Limb Spasticity NCT02145676 | Allergan | Phase 3 |
| Completed | Radial Extracorporeal Shock Wave Therapy for Spastic Plantar Flexor Muscles in Young Children With Cerebral Pa NCT02719483 | The First Hospital of Jilin University | N/A |
| Unknown | The Effectiveness of Early Botulinum Toxin A Injection for Lower Limbs Spasticity in Subacute Stroke Adults NCT02505802 | Sir Run Run Shaw Hospital | Phase 4 |
| Completed | Safety of Xeomin for Lower Limb Spasticity in Multiple Sclerosis Patients NCT01968902 | Multiple Sclerosis Center of Northeastern New York | Phase 4 |
| Completed | An Adult Spasticity Registry of OnabotulinumtoxinA Treatment NCT01930786 | Allergan | — |
| Completed | Developing Optimal Focal Muscle Vibration for Improving Spasticity NCT01915342 | Seoul National University Hospital | N/A |
| Completed | BOTOX® Open-Label Treatment in Pediatric Lower Limb Spasticity NCT01603641 | Allergan | Phase 3 |
| Completed | BOTOX® Open-Label Treatment in Pediatric Upper Limb Spasticity NCT01603615 | Allergan | Phase 3 |
| Completed | BOTOX® Treatment in Pediatric Lower Limb Spasticity NCT01603628 | Allergan | Phase 3 |
| Completed | BOTOX® Treatment in Pediatric Upper Limb Spasticity NCT01603602 | Allergan | Phase 3 |
| Completed | BOTOX® Treatment in Adult Patients With Post-Stroke Lower Limb Spasticity NCT01575054 | Allergan | Phase 3 |
| Completed | Effect of Botox and Vibration on Bone in Children With Cerebral Palsy NCT01803464 | University of Delaware | N/A |
| Completed | Effects of Zolmitriptan on Sensory Transmission After Spinal Cord Injury NCT01587170 | University of Alberta | — |
| Completed | Early Use of Botulinum Toxin in Spasticity Post Stroke. NCT01882556 | Sandwell & West Birmingham Hospitals NHS Trust | Phase 2 |
| Completed | Dysport® Pediatric Lower Limb Spasticity Follow-on Study NCT01251380 | Ipsen | Phase 3 |
| Completed | Dysport® Pediatric Lower Limb Spasticity Study NCT01249417 | Ipsen | Phase 3 |
| Completed | Observational Study of Botox® Treatment for Patients With Upper Limb Adult Spasticity NCT01387074 | Allergan | — |
| Completed | Assessment and Management of Post-Stroke Spasticity With Botulinum Toxin-A NCT01751373 | Sunnybrook Health Sciences Centre | N/A |
| Completed | Retrospective Study of Patients With Spasticity in the Spanish Population NCT01383681 | Allergan | — |
| Completed | Botulinum Toxin A Adult Gastrocnemius Muscle Study NCT01278576 | The Catholic University of Korea | Phase 4 |
| Completed | The Efficacy and Safety of MEDITOXIN® in Children With Cerebral Palsy NCT01256021 | Medy-Tox | Phase 4 |
| Completed | Cyproheptadine and Chlorpromazine Effects on Spasticity NCT01509885 | University of Alberta | — |
| Completed | Exploring Advanced Imaging Techniques to Characterize Botulinum Toxin Diffusion in Human Muscle NCT01412008 | New York Presbyterian Hospital | N/A |
| Completed | To Document the Effectiveness of BoNT-A Injection in Adult Subjects With Upper Limb Spasticity Following Strok NCT01020500 | Ipsen | — |
| Terminated | Bilateral Versus Unilateral Task Retraining Using the SaeboFlex Orthosis NCT00893776 | University of Missouri-Columbia | N/A |
| Unknown | Botulinum Toxin Injection Efficiency NCT01041157 | Jyväskylä Central Hospital | Phase 1 |
| Completed | Safety and Efficacy of BOTOX® (Botulinum Toxin Type A) in Korea NCT02043145 | Allergan | — |
| Completed | Effect of Joint Mobilization on Alpha Motoneuron Reflex Excitability NCT01153022 | Universidad Autónoma de Manizales, Colombia | N/A |
| Completed | A Safety and Efficacy Study of XP19986 in Subjects With Spasticity Due to Spinal Cord Injury NCT00557973 | XenoPort, Inc. | Phase 2 |
| Completed | BOTOX® Economic Spasticity Trial (BEST) NCT00549783 | Allergan | Phase 4 |
| Terminated | Safety and Preliminary Effectiveness of AV650 in Patients With Spasticity Associated With Multiple Sclerosis NCT00532532 | Avigen | Phase 2 |
| Completed | MDs on Botox Utility (MOBILITY) NCT00535938 | Allergan | — |
| Terminated | Safety and Preliminary Effectiveness of AV650 in Patients With Spasticity Due to Spinal Cord Injury NCT00531466 | Avigen | Phase 2 |
| Completed | Study of Nighttime Dosing of Sublingual Tizanidine (12 mg) in Multiple Sclerosis (MS) Patients With Significan NCT00358293 | Teva GTC | Phase 1 / Phase 2 |
| Terminated | MUltiple Sclerosis and Extract of Cannabis (MUSEC) Study NCT00552604 | Institut fur Klinische Forschung, Germany | Phase 3 |
| Recruiting | The Muscle in Children With Cerebral Palsy - Longitudinal Exploration of Microscopic Muscle Structure. NCT05497609 | Eva Ponten | — |
| Completed | Effects on Quality of Life Following Dysport Treatment in Post-stroke Spasticity of the Arm NCT00216411 | Ipsen | Phase 4 |
| Completed | Post Marketing Surveillance Study of Dysport NCT00210431 | Ipsen | — |
| Completed | Study of Responsiveness of Seven Functional Tasks in Patients With Poststroke Upper Limb Spasticity With Botul NCT00651690 | Allergan | Phase 2 |
| Completed | Safety Study of Botulinum Toxin Type A in Post-Upper Limb Stroke Patients With Reduced Lung Function NCT00076687 | Allergan | Phase 2 |
| Completed | Safety Study of Botulinum Toxin Type A for the Treatment of Focal Upper Limb Poststroke Spasticity NCT00651729 | Allergan | Phase 2 |
| Completed | Asian Botulinum Clinical Trial Designed for Early Stroke Spasticity NCT00234546 | Ipsen | Phase 4 |
| Completed | The Use of Penile Vibratory Stimulation to Decrease Spasticity Following Spinal Cord Injury NCT00223873 | US Department of Veterans Affairs | N/A |
| Completed | Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury NCT00041717 | Acorda Therapeutics | Phase 3 |
| Completed | Comparison of Safety and Efficacy of Tizanidine Hydrochloride Capsules Versus Zanaflex® (Tizanidine Hydrochlor NCT00047580 | Elan Pharmaceuticals | Phase 3 |
| Completed | Safety and Efficacy of Oral Fampridine-Sustained Release (SR) for the Treatment of Spasticity Resulting From S NCT01683838 | Acorda Therapeutics | Phase 3 |
| Recruiting | How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery. NCT05506228 | Eva Ponten | — |
| Completed | Physiologic Studies of Spasticity NCT00014976 | National Institute of Neurological Disorders and Stroke (NINDS) | — |
| Completed | Botulinum Toxin (BOTOX) for Cerebral Palsy NCT00060957 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Phase 2 |