| Withdrawn | UNITY VCS Vitreoretinal Surgery NCT07054281 | Alcon Research | N/A |
| Not Yet Recruiting | Retinal Clinical Assessment With AI-derived Quantitative Information NCT07291960 | Beijing Tongren Hospital | — |
| Recruiting | No Endotamponade for Macular Hole Repair: the NEMAR Study NCT06908824 | Chinese University of Hong Kong | N/A |
| Enrolling By Invitation | Intraocular Gas Tamponade for Treatment of Large Idiopathic Macular Holes NCT06927544 | The Filatov Institute of Eye Diseases and Tissue Therapy | N/A |
| Active Not Recruiting | Head Position Monitoring After Pars Planar Vitrectomy NCT06985030 | Seoul National University Hospital | — |
| Enrolling By Invitation | Minimal Vitrectomy and ILM Flap with Sodium Hyaluronate Gel for MH NCT06685328 | Jie Zhong | N/A |
| Active Not Recruiting | Efficacy and Safety of Myopic Macular Hole Closure Surgery Without Endotamponade Agent NCT07129798 | Chinese University of Hong Kong | N/A |
| Completed | Performance Comparison of the 25 Gauge 20,000cpm HYPERVIT Dual Blade vs. 10,000cpm ULTRAVIT Vitrectomy Cutter NCT05710458 | The University of Hong Kong | N/A |
| Completed | Visual Acuity and Optical Coherence Tomography One Year After ILM-flap Transposition NCT03465865 | Vienna Institute for Research in Ocular Surgery | — |
| Completed | Internal Limiting Membrane Peeling-reposition to Treat Idiopathic Macular Holes NCT03020459 | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | N/A |
| Completed | Fourier Transformed Infrared Spectroscopy in Macular Surgery NCT03452748 | Vienna Institute for Research in Ocular Surgery | N/A |
| Unknown | Optical Coherence Tomography - Rescan During Dissection of Macular Membranes NCT02748421 | Federal University of São Paulo | N/A |
| Completed | Applicability of the Acai Fruit (Euterpe Oleracea) Dye for Chromovitrectomy in Humans NCT02691429 | Federal University of São Paulo | N/A |
| Unknown | Analysis of Aqueous and Vitreous Humor NCT02067013 | California Retina Consultants | Phase 2 |
| Completed | Effects of Different Area of Internal Limiting Membrane Peeling (ILM) Peeling on Anatomical Outcomes in Macula NCT02930369 | Peking University People's Hospital | Phase 4 |
| Terminated | Objective Evaluation of Postoperative Positioning in Macular Hole Surgery NCT02295943 | Helse Stavanger HF | N/A |
| Recruiting | DISCOVER Study: Microscope-integrated Intraoperative OCT Study NCT02423213 | The Cleveland Clinic | — |
| Completed | An Objective Evaluation of Postoperative Positioning in Macular Hole Surgery NCT02011165 | Helse Stavanger HF | — |
| Unknown | Comparison of Postoperative Aqueous Flare After 20G Versus 23G Pars Plana Vitrectomy NCT01969929 | University of Cologne | N/A |
| Completed | Fundus Autofluorescence After Macular Hole Surgery NCT02628262 | Makoto Inoue | — |
| Terminated | Safety and Efficacy of Double Staining With Brilliant Blue G for Macular Surgery NCT01820520 | Asociación para Evitar la Ceguera en México | Phase 3 |
| Completed | Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy NCT01627977 | Federal University of São Paulo | Phase 3 |
| Completed | Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO NCT01692938 | Optos, PLC | — |
| Completed | Air Tamponade in Macular Hole Surgery NCT01680068 | Helse Stavanger HF | N/A |
| Completed | Comparative Study Between Early Vitrectomy and Observation for Spontaneous Closure of Traumatic Macular Hole NCT01509092 | Peking University Third Hospital | N/A |
| Completed | PIONEER: Intraoperative and Perioperative OCT Study NCT02423161 | The Cleveland Clinic | — |
| Completed | Microperimetry and Optical Coherence Tomography (OCT) in Idiopathic Macular Hole NCT01757600 | Centre Hospitalier Universitaire Dijon | — |
| Completed | Observational Study - ILM Peeling NCT01083056 | University Hospital Tuebingen | — |
| Completed | Effect of Topical Aqueous Suppressants on Intraocular Gas Duration Following Pars Plana Vitrectomy NCT01257698 | Mid Atlantic Retina | N/A |
| Completed | Asymmetrical Recovery of Cone Outer Segment Tips and Foveal Displacement After Macular Hole Surgery NCT01959776 | Kyorin University | N/A |
| Completed | Optical Coherence Tomography in Gas-filled Eyes NCT01266746 | Kyorin University | — |
| Unknown | Brilliant Blue Versus Indocyanine Green NCT01083004 | University of Cologne | Phase 3 |
| Completed | Comparison of a Spectral OCT/SLO With the Stratus OCT for Imaging Various Retinal Pathologies NCT00408720 | The New York Eye & Ear Infirmary | — |
| Completed | Combined Versus Successive Macular Hole and Cataract Surgery NCT01069029 | Centre Hospitalier Universitaire Dijon | — |
| Terminated | Study of OT-551 Eye Drops to Prevent or Delay Progression of Nuclear Cataracts Following Vitreous Removal NCT00333060 | Othera Pharmaceuticals | Phase 2 |
| Completed | Alleviated Positioning for Small Macular Holes NCT00190164 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Internal Limiting Membrane Peeling for Large Macular Holes NCT00190190 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Membrane Blue Versus Infracyanine Green NCT00555269 | The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery | — |
| Completed | Macular Hole in Diabetic Retinopathy NCT00737074 | National Taiwan University Hospital | — |