| Not Yet Recruiting | Proprio Spine Measurement Tool NCT07023393 | Duke University | N/A |
| Recruiting | EvaluatIon of Autologous Nucleus Pulposus Cells (aNPC) in Degenerative Disc Disease NCT07168603 | ASTEROGENE Biomedical Co. Ltd. | Phase 1 / Phase 2 |
| Withdrawn | The Role of Disc Nutrition in the Etiology and Clinical Treatment of Disc Degeneration NCT04134910 | VA Office of Research and Development | N/A |
| Enrolling By Invitation | RenewDisc Trial: Endoscopic Discectomy and Autologous Stem Cell Therapy for Discogenic Low Back Pain NCT07338877 | EPC Education s.r.o. | — |
| Recruiting | Safety and Performance of the SpineVision Posterior Fixation Systems in Thoracolumbar Spinal Treatment NCT06342765 | SPINEVISION SAS | — |
| Recruiting | A Post Market Surveillance on INFUSE Bone Graft NCT05299762 | Medtronic Spinal and Biologics | — |
| Recruiting | Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure NCT05648474 | Alphatec Spine, Inc. | — |
| Withdrawn | Comparison of Three Approaches of Electrode Placement to Detect Changes in Motor Evoked Potentials During Spin NCT05098431 | Allina Health System | N/A |
| Completed | Minimally Invasive Decompression and Fusion Versus Open for Degenerative Lumbar Stenosis NCT04594980 | N.N. Priorov National Medical Research Center of Traumatology and Orthopedics | N/A |
| Recruiting | Safety and Performance of the Hexanium TLIF System in the Treatment of Degenerative Disc Disease NCT05997121 | SPINEVISION SAS | — |
| Active Not Recruiting | Safety and Performance of the SPINEVISION Hexanium ACIF in the Treatment of Cervical Spine Degenerative Disc D NCT06155409 | SPINEVISION SAS | — |
| Recruiting | Efficacy of Intradiscal Injection of Autologous BM-MSC in Subjects With Chronic LBP Due to Multilevel Lumbar I NCT05066334 | Fondazione Policlinico Universitario Campus Bio-Medico | Phase 2 |
| Withdrawn | Minimally Invasive Surgery Versus Traditional Open Surgery In The Treatment Of Single Level Lumbar Stenosis NCT04408846 | Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan | N/A |
| Completed | Russian Disc Degeneration Study NCT04600544 | Novosibirsk State University | — |
| Withdrawn | Minimally Invasive Surgery Techniques for One-level Degenerative Lumbar Deformities Correction NCT03908203 | Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan | N/A |
| Unknown | Intervertebral DXM Gel Injection in Adults With Painful Lumbar Degenerative Disc Disease NCT04727385 | Gelmetix | N/A |
| Enrolling By Invitation | Dose Responsiveness as a Measure of Clinical Effectiveness During Neuromonitored Spine Surgery NCT05110833 | Allina Health System | — |
| Completed | Efficacy of Intradiscal Injection of Autologous BM-MSC in Worker Patients Affected by Chronic LBP Due to Multi NCT04759105 | Fondazione Policlinico Universitario Campus Bio-Medico | Phase 2 |
| Completed | Smoking Effect on Lumbar Intervertebral Disc Degeneration NCT04702126 | Fatih Sultan Mehmet Training and Research Hospital | — |
| Withdrawn | Clinical Evidence of Robot Guided vs. Navigated vs. Free Hand Lumbar Spinal Fusion NCT02998060 | Marc Schröder | N/A |
| Unknown | Identification of Biomarkers and Molecular Targets Involved on Intervertebral Disc Degeneration and Discogenic NCT06349226 | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | — |
| Unknown | Cortical Bone Trajectory Screws vs. Traditional Pedicle Screws Fixation NCT03105167 | Second Affiliated Hospital of Wenzhou Medical University | N/A |
| Recruiting | Open Access Database of Standing Full Body Radiographs in Asymptomatic Volunteers NCT03076658 | University of Colorado, Denver | N/A |
| Unknown | Protection of Autonomic Nervous System During Lower Spine Surgical Procedures: A Safety and Feasibility Study NCT02873182 | Stanley Skinner | N/A |
| Completed | Adjacent Segment Mechanics in Cervical Arthrodesis Patients NCT03028402 | University of Pittsburgh | — |
| Completed | 5-Year Global Study on MAST™ Minimally Invasive Fusion Procedures to Treat Degenerative Lumbar Spine (MASTERS- NCT02617563 | Medtronic Spinal and Biologics | — |
| Completed | Comparison of nanOss Cervical IBF System to C-Plus PEEK IBF Device With Autograft NCT02586116 | RTI Surgical | N/A |
| Terminated | A Prospective Study of NuCel® in Cervical Spine Fusion NCT02381067 | NuTech Medical, Inc | N/A |
| Completed | Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery NCT02535000 | Serviço de Anestesiologia de Joinville | Phase 4 |
| Completed | Efficacy Study of NuCel® in Patients Undergoing Fusion of the Lumbar Spine NCT02023372 | NuTech Medical, Inc | N/A |
| Unknown | Predicting the Outcome of Total Knee Arthroplasty and Spinal Surgeon NCT01989481 | Beijing Jishuitan Hospital | — |
| Unknown | Prospective Study of Safety and Efficacy of InQu® Bone Graft Extender in Lumbar Interbody Fusion Surgery NCT02400762 | ISTO Technologies, Inc. | — |
| Completed | Patient Registry to Observe Outcomes Following Implantation of the VariLift Interbody Fusion Device NCT01944345 | Wenzel Spine | — |
| Unknown | Efficiency and Safety Study of Pamidronate in Inflammatory Back Pain Due to Degenerative Disk Disease NCT01799616 | University Hospital, Clermont-Ferrand | Phase 2 |
| Completed | Safety and Efficacy With NOVOCART® Disc Plus (ADCT) for the Treatment of Degenerative Disc Disease in Lumbar S NCT01640457 | Tetec AG | Phase 1 / Phase 2 |
| Unknown | Tissue Collection for Understanding Intervertebral Disc Degeneration and Back Pain NCT01633034 | Northwell Health | — |
| Completed | Lumbar Disc Space Height in Young Disc Herniation and Degeneration Patients NCT02351206 | Jaseng Hospital of Korean Medicine | — |