| Recruiting | A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Idiopathic Hypersomnia (IH) NCT07500090 | Harmony Biosciences Management, Inc. | Phase 3 |
| Not Yet Recruiting | Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic NCT06644573 | Nyree Penn | Phase 1 |
| Not Yet Recruiting | Effect of Low Sodium Oxybate (LXB) on Autonomic Symptom Burden in Idiopathic Hypersomnia Patients With Postura NCT07077278 | Stanford University | Phase 4 |
| Recruiting | A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia NCT07096674 | Centessa Pharmaceuticals (UK) Limited | Phase 2 |
| Recruiting | A Novel Approach to Manage Symptoms of Narcolepsy and Idiopathic Hypersomnia NCT07006233 | University of Sydney | N/A |
| Recruiting | A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Idiopathic Hypersomnia NCT06843590 | Alkermes, Inc. | Phase 2 |
| Recruiting | A Study of TAK-360 in Adults With Idiopathic Hypersomnia NCT06812078 | Takeda | Phase 2 |
| Recruiting | A Long-Term Study of ALKS 2680 in Subjects With Narcolepsy and Idiopathic Hypersomnia NCT06767683 | Alkermes, Inc. | Phase 2 / Phase 3 |
| Recruiting | A Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia NCT06752668 | Centessa Pharmaceuticals (UK) Limited | Phase 2 |
| Recruiting | Mind-wandering and Predictive Processes in Narcolepsy: a Putative Mechanism Through Covert REM Intrusions NCT06457945 | Hospices Civils de Lyon | N/A |
| Recruiting | Deciphering the Interactions Between Food Intake, Sleepiness, and Nighttime Sleep Quality in Patients With Typ NCT06484348 | Hospices Civils de Lyon | N/A |
| Not Yet Recruiting | Efficacy and Tolerance of Solriamfetol in Patients Affected with Idiopathic Hypersomnia. NCT06590662 | University Hospital, Montpellier | Phase 2 |
| Recruiting | a Chronobiological Treatment Combining Evening Melatonin and Morning Light Therapy in Idiopathic Hypersomnia: NCT06252571 | University Hospital, Strasbourg, France | Phase 2 |
| Active Not Recruiting | Safety and Efficacy of FT218 in Idiopathic Hypersomnia (REVITALYZ) NCT06525077 | Avadel | Phase 3 |
| Completed | Improving Social Relationships for Adolescents With Central Disorders of Hypersomnolence NCT06251063 | Boston Children's Hospital | N/A |
| Recruiting | Low Sodium Oxybate in Patients With Idiopathic Hypersomnia NCT05837091 | Mayo Clinic | Phase 4 |
| Unknown | Local Sleep in Idiopathic Hypersomnia NCT06153615 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | A Study to Investigate the Effect of XYWAV on Sleepiness, Polysomnography, and Functional Outcomes in Particip NCT05875974 | Jazz Pharmaceuticals | Phase 4 |
| Recruiting | Spectrometry (MRM) Versus I 125 Radioimmunoassay (RIA) for Quantification of Orexin-A of Patients With Hyperso NCT05615584 | University Hospital, Montpellier | N/A |
| Completed | Placebo-Controlled, Double-Blind, Study to Determine the Safety and Efficacy of SDX in Patients With IH NCT05668754 | Zevra Therapeutics | Phase 2 |
| Unknown | Psychiatric Co-morbidities and Socio-demographic Characteristics in Patients With Idiopathic Hypersomnia NCT05778721 | University Hospital, Toulouse | — |
| Completed | A Long-Term Safety and Effectiveness Study to Evaluate Pitolisant in Adult Patients With Idiopathic Hypersomni NCT05458128 | Harmony Biosciences Management, Inc. | Phase 3 |
| Completed | A Phase 3 Study to Assess the Safety and Efficacy of Pitolisant in Adult Patients With Idiopathic Hypersomnia NCT05156047 | Harmony Biosciences Management, Inc. | Phase 3 |
| Enrolling By Invitation | Cardiovascular and Cognitive Implications of Central Disorders of Hypersomnolence and Their Treatments NCT05371483 | Mayo Clinic | — |
| Recruiting | Mainz Register of Patients With Sleep Disorders NCT05321355 | Johannes Gutenberg University Mainz | — |
| Completed | Anesthetic Management of Patients With Chronic Sleep Disorders NCT04827329 | University Hospital, Montpellier | — |
| Completed | A Study of a Single Intravenous Infusion Dose of TAK-925 in Participants With Idiopathic Hypersomnia NCT04091438 | Millennium Pharmaceuticals, Inc. | Phase 1 |
| Recruiting | International Swiss Primary Hypersomnolence and Narcolepsy Cohort Study NCT04330963 | Insel Gruppe AG, University Hospital Bern | — |
| Completed | Clarithromycin Mechanisms in Hypersomnia Syndromes NCT04026958 | Emory University | Phase 2 |
| Completed | Modafinil Versus Amphetamines for the Treatment of Narcolepsy Type 2 and Idiopathic Hypersomnia NCT03772314 | Emory University | Phase 2 |
| Completed | Psychosocial Adjunctive Treatment for Hypersomnia (PATH) NCT03904238 | Northwestern University | N/A |
| Completed | A Multicenter Study of the Efficacy and Safety of JZP-258 in the Treatment of Idiopathic Hypersomnia (IH) With NCT03533114 | Jazz Pharmaceuticals | Phase 3 |
| Completed | Sodium Oxybate in Idiopathic Hypersomnia NCT03597555 | University Hospital, Montpellier | Phase 2 / Phase 3 |
| Unknown | A Study of Oral BTD-001 in Adults With Idiopathic Hypersomnia NCT03542851 | Balance Therapeutics | Phase 2 |
| Completed | The Role of the Circadian System in Neurological Sleep-wake Disorders NCT03356938 | Esther Werth | N/A |
| Completed | A Study of Safety and Efficacy of BTD-001 in Treatment of Patients With Idiopathic Hypersomnia (IH) or Narcole NCT02512588 | Balance Therapeutics | Phase 2 |
| Completed | Flumazenil for the Treatment of Primary Hypersomnia NCT01183312 | Lynn Marie Trotti | Phase 1 / Phase 2 |
| Recruiting | Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford NCT01793168 | Sanford Health | — |
| Completed | Clarithromycin for the Treatment of Hypersomnia NCT01146600 | Lynn Marie Trotti | Phase 2 |