| Enrolling By Invitation | Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome NCT06342999 | Mauro H. Schenone | N/A |
| Not Yet Recruiting | Study of Intramyocardial Injection of Ventrix Bio Extracellular Matrix (VentriGel) to Assess the Safety and Fe NCT06461676 | Emory University | Phase 1 |
| Recruiting | Prenatal Maternal Mental Health and Neurodevelopment in Congenital Heart Disease NCT06711666 | Institut National de la Santé Et de la Recherche Médicale, France | — |
| Terminated | Hypoplastic Left Heart Syndrome: Subendocardial Viability After Norwood Palliation NCT05709275 | IRCCS Policlinico S. Donato | — |
| Active Not Recruiting | Evaluation of Lomecel-B™ Injection in Patients With Hypoplastic Left Heart Syndrome (HLHS): A Phase IIb Clinic NCT04925024 | Longeveron Inc. | Phase 2 |
| Completed | Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Pos NCT04452188 | University of Michigan | N/A |
| Recruiting | Effect of Fetal Aortic Valvuloplasty on Outcomes NCT05386173 | Queen Silvia Children's Hospital, Gothenburg, Sweden | — |
| Unknown | Impact of NAVA Ventilation on Brain Oxygenation and Perfusion in Children With Congenital Heart Disease NCT04581668 | St. Justine's Hospital | N/A |
| Terminated | Cold Heart Study: A Randomized Pilot Trial of Surfactant Therapy NCT04181255 | University of Michigan | Phase 1 |
| Completed | The CHILD Trial: Hypoplastic Left Heart Syndrome Study. NCT03406884 | Joshua M Hare | Phase 1 |
| Active Not Recruiting | Intramyocardial Injection of Autologous Umbilical Cord Blood Derived Mononuclear Cells During Surgical Repair NCT03779711 | Timothy J Nelson, MD, PhD | Phase 2 |
| Completed | Physical Activity Promotion in Children and Adolescents With Single Ventricle Physiology (MedBike) NCT04056416 | University of Alberta | N/A |
| Withdrawn | Initiation of Resuscitation While Attached to the Cord With Congenital Heart Disease NCT03690245 | University of Alberta | N/A |
| Completed | Safety of Autologous Cord Blood Cells in HLHS Patients During Norwood Heart Surgery NCT03431480 | Murdoch Childrens Research Institute | Phase 1 |
| Completed | Maternal Hyperoxygenation in Congenital Heart Disease NCT03136835 | The Hospital for Sick Children | Phase 1 / Phase 2 |
| Unknown | Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left Ventricle NCT03079401 | Boston Children's Hospital | Phase 1 / Phase 2 |
| Recruiting | Cardiac Stem/Progenitor Cell Infusion in Univentricular Physiology (APOLLON Trial) NCT02781922 | Metcela Inc. | Phase 3 |
| Completed | Cerebral Anatomy, Hemodynamics and Metabolism NCT02919956 | Children's Hospital of Philadelphia | — |
| Unknown | Cardiovascular Response to Maternal Hyperoxygenation in Fetal Congenital Heart Disease NCT03147014 | Beijing Anzhen Hospital | N/A |
| Completed | Ambrisentan in Single Ventricle NCT02080637 | Kevin Hill | Phase 2 |
| Terminated | Allogeneic hMSC Injection in Patients With Hypoplastic Left Heart Syndrome NCT02398604 | Longeveron Inc. | Phase 1 |
| Withdrawn | Positive Pressure Ventilation and Sternal Closure in HLHS NCT02455713 | The Hospital for Sick Children | — |
| Completed | Fluid Balance in Children Undergoing Fontan Surgery NCT02306057 | Oslo University Hospital | — |
| Completed | Safety Study of Autologous Umbilical Cord Blood Cells for Treatment of Hypoplastic Left Heart Syndrome NCT01883076 | Timothy J Nelson, MD, PhD | Phase 1 |
| Completed | Cardiac Progenitor Cell Infusion to Treat Univentricular Heart Disease (PERSEUS) NCT01829750 | Okayama University | Phase 2 |
| Completed | Impact of Early Intervention on Maternal Stress in Mothers of Fetuses Diagnosed With Single Ventricle Physiolo NCT02462434 | University of Michigan | N/A |
| Completed | Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN NCT02184169 | Boston Children's Hospital | N/A |
| Completed | Fetal Intervention for Aortic Stenosis and Evolving Hypoplastic Left Heart Syndrome NCT01736956 | University of California, San Francisco | N/A |
| Completed | A Prospective Study of Patients With Hypoplastic Left Heart Syndrome (HLHS) Following Stage II Surgical Pallia NCT01708863 | Timothy J Nelson, MD, PhD | — |
| Completed | SVRII Family Factors Study NCT01582529 | Medical College of Wisconsin | — |
| Terminated | Safety and Feasibility Study of Umbilical Cord Blood Cells for Infants With Hypoplastic Left Heart Syndrome NCT01445041 | Michael Cotten | Phase 1 |
| Completed | Genetic Determinants of Congenital Heart Disease Outcomes NCT01656941 | University of Michigan | — |
| Completed | Study of Placebo or Bosentan to Treat Patients With Single Ventricle Physiology. NCT01292551 | Rigshospitalet, Denmark | Phase 2 |
| Completed | Transcoronary Infusion of Cardiac Progenitor Cells in Patients With Single Ventricle Physiology NCT01273857 | Okayama University | Phase 1 |
| Completed | Prophylactic Peritoneal Dialysis Decreases Time to Achieve a Negative Fluid Balance After the Norwood Procedur NCT01215240 | University of Alberta | N/A |
| Completed | Comparison of Feeding Strategies for Hypoplastic Left Heart Syndrome Infants NCT02657629 | Columbia University | N/A |
| Terminated | Global and Regional Myocardial Strain and Power Output In Patients With Single Ventricles Using Novel MRI Tech NCT01107990 | University of California, San Francisco | — |
| Completed | Impact of Vitamin C on Endothelial Function and Exercise Capacity in Fontan-Palliated Patients NCT00974025 | University of Michigan | N/A |
| Completed | Cerebral Perfusion During Neonatal Cardiac Surgery NCT01032876 | UMC Utrecht | N/A |
| Completed | Sildenafil After the Fontan Operation NCT00507819 | Children's Hospital of Philadelphia | Phase 2 |
| Terminated | Examining Developmental Changes in Heart Contractions of Children With Congenital Heart Defects NCT00860327 | Emory University | — |
| Completed | Biomarker Study for Heart Failure in Children With Single Ventricle Physiology NCT00571233 | University of California, San Francisco | — |
| Completed | Erythropoetin Neuroprotection for Neonatal Cardiac Surgery NCT00513240 | Baylor College of Medicine | Phase 1 / Phase 2 |
| Completed | Family Adaptation Study Following the Diagnosis of Hypoplastic Left Heart Syndrome in a Newborn NCT00734643 | Medical College of Wisconsin | — |
| Completed | Near-infrared Spectroscopy (NIRS) Neurodevelopmental Outcomes NCT00464100 | Medical College of Wisconsin | — |
| Completed | Single Ventricle Outcome NCT00308217 | Emory University | — |
| Withdrawn | Sleep Disordered Breathing in Children With Single Ventricle Physiology NCT00156455 | University of Rochester | — |