| Recruiting | Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease NCT07478172 | University of Missouri-Columbia | N/A |
| Recruiting | Neuromodulation to Enhance Motor Function in HSP NCT07417943 | Rahul Sachdeva | N/A |
| Not Yet Recruiting | Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type NCT06948019 | BlackfinBio Ltd | Phase 1 / Phase 2 |
| Recruiting | A Prospective Cohort Study of Surgical Treatment for Foot Deformities in HSP NCT06936163 | Shanghai 6th People's Hospital | — |
| Recruiting | A Prospective Cohort Study of ITB Treatment for HSP NCT06844734 | Shanghai 6th People's Hospital | — |
| Recruiting | Flexibility, Resistance, Aerobic, Movement Execution Training in Adults With Hereditary Spastic Paraplegia NCT06742697 | IRCCS Eugenio Medea | N/A |
| Recruiting | Calcium Folinate Treatment of Spastic Paraplegia 56 NCT06478238 | Shanghai 6th People's Hospital | EARLY_Phase 1 |
| Recruiting | Spastic Paraplegia - Centers of Excellence Research Network NCT06553976 | Boston Children's Hospital | — |
| Recruiting | Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology NCT07136844 | Centre Hospitalier Universitaire de Liege | N/A |
| Recruiting | STOP-HSP.Net: a Registry for Hereditary Spastic Paraplegia as an Integration Tool for Future Therapeutic Strat NCT06572046 | IRCCS Fondazione Stella Maris | — |
| Completed | Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals NCT06117020 | Motric Bio | Phase 1 |
| Recruiting | Natural History Study of Patients with HPDL Mutations NCT05848271 | University of California, San Diego | — |
| Withdrawn | A Pilot Study of Shockwave Therapy in HSP NCT05411627 | Spaulding Rehabilitation Hospital | N/A |
| Completed | Identification of Modifying Factors in Hereditary Spastic Paraplegia NCT05373082 | Assistance Publique - Hôpitaux de Paris | — |
| Recruiting | Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq) NCT05354622 | Boston Children's Hospital | — |
| Completed | Assessment of the Psychophysical State During Rehabilitation Treatment With Lokomat NCT05767268 | IRCCS Eugenio Medea | — |
| Completed | Trehalose Administration in Subjects With Spastic Paraplegia 11 (3AL-SPG11) NCT04912609 | IRCCS Fondazione Stella Maris | — |
| Active Not Recruiting | Phenotype, Genotype and Biomarkers 2 NCT04875416 | University of Miami | — |
| Completed | Effect of Dalfampridine in Patients With Hereditary Spastic Paraplegia NCT05613114 | European University of Lefke | N/A |
| Recruiting | Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia NCT04712812 | Boston Children's Hospital | — |
| Completed | Improving Gait Adaptability in Hereditary Spastic Paraplegia NCT04180098 | Radboud University Medical Center | N/A |
| Recruiting | Phenotypes, Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related Disorders NCT03981276 | Dr. Rebecca Schule | — |
| Recruiting | The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4 NCT03206190 | University Hospital Tuebingen | N/A |
| Completed | Studying Cognition in SPG4 NCT03104088 | University Hospital Tuebingen | — |
| Completed | Repetitive Transcranial Magnetic Stimulation as Therapy in Hereditary Spastic Paraplegia and Adrenomyeloneurop NCT03627416 | Jakub Antczak | N/A |
| Completed | A Patient Centric Motor Neuron Disease Activities of Daily Living Scale NCT02852278 | University of South Florida | — |
| Terminated | Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31 NCT02859428 | National Institute of Neurological Disorders and Stroke (NINDS) | — |
| Completed | Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia NCT02604186 | University of Campinas, Brazil | Phase 2 / Phase 3 |
| Enrolling By Invitation | Phenotype, Genotype & Biomarkers in ALS and Related Disorders NCT02327845 | University of Miami | — |
| Completed | Physiotherapy in Hereditary Spastic Paraplegia NCT03961906 | University Hospital Tuebingen | Phase 2 |
| Recruiting | Robot-assisted Walking Treatment in Hereditary Spastic Paraplegia (HSP) NCT06728787 | IRCCS Eugenio Medea | — |
| Completed | Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and NCT00023075 | National Institute of Neurological Disorders and Stroke (NINDS) | — |