| Enrolling By Invitation | Chronic Exogenous Ketosis in HFpEF NCT06937320 | Duke University | Phase 2 |
| Terminated | Ablation Versus Medical Management of Atrial Fibrillation in HFpEF NCT04282850 | Inova Health Care Services | N/A |
| Withdrawn | Chlorhexidine Mouthwash and Oral Nitrate in Adults With Pulmonary Hypertension NCT03787082 | Gladwin, Mark, MD | Phase 1 |
| Withdrawn | Iron Substitution With Ferric Carboxymaltose as Treatment Strategy for Heart Failure Patients With Preserved E NCT05477498 | Cantonal Hosptal, Baselland | Phase 4 |
| Unknown | High-intensity Interval Training in Heart Failure Patients With Preserved Ejection Fraction NCT03184311 | University of Basel | N/A |
| Completed | Unsaturated Fatty Acids to Improve Cardiorespiratory Fitness in Obesity and HFpEF NCT03966755 | Virginia Commonwealth University | N/A |
| Unknown | Flow Regulation by Opening the Septum in Patients With Heart Failure Trial NCT03751748 | Unity Health Toronto | N/A |
| Completed | Renal Hemodynamics in Patients With HFpEF NCT03672591 | University of Erlangen-Nürnberg Medical School | — |
| Completed | Hemodynamic Evaluation of Levosimendan in Patients With PH-HFpEF NCT03541603 | Tenax Therapeutics, Inc. | Phase 2 |
| Completed | Open-Label Rollover Study of Levosimendan in PH-HFpEF Patients NCT03624010 | Tenax Therapeutics, Inc. | Phase 2 |
| Completed | β-blockers Withdrawal in Patients With HFpEF and Chronotropic Incompetence: Effect on Functional Capacity (Pre NCT03871803 | Fundación para la Investigación del Hospital Clínico de Valencia | Phase 4 |
| Recruiting | Imaging Histone Deacetylase in the Heart NCT03549559 | Massachusetts General Hospital | N/A |
| Completed | Hemodynamic-GUIDEd Management of Heart Failure NCT03387813 | Abbott Medical Devices | N/A |
| Suspended | Abnormal Vascular, Metabolic, and Neural Function During Exercise in Heart Failure With Preserved Ejection Fra NCT03465072 | University of Texas Southwestern Medical Center | N/A |
| Completed | Validation of CMR Against Invasive Haemodynamics in Patients With HFpEF NCT03251183 | Goethe University | — |
| Recruiting | New Orleans Pulmonary Hypertension Biobank NCT03269630 | Louisiana State University Health Sciences Center in New Orleans | — |
| Completed | Neuromodulation to Treat Patients With Heart Failure With Preserved Ejection Fraction NCT03327649 | University of Oklahoma | N/A |
| Unknown | Inhaled Iloprost and Exercise Hemodynamics and Ventricular Performance in Heart Failure With Preserved Ejectio NCT03620526 | National Taiwan University Hospital | Phase 4 |
| Completed | Unsaturated Fatty Acids Enriched-diet to Improve Cardiorespiratory Fitness, Metabolic Flexibility and Glucose NCT03310099 | Virginia Commonwealth University | N/A |
| Completed | Effects of Iron Therapy in Heart Failure With Preserved Ejection Fraction and Iron Deficiency (PREFER-HF) NCT03833336 | Institut de Recerca Biomèdica de Lleida | Phase 3 |
| Completed | Heart Function in Patients Assessed for Sleep Apnoea NCT03226652 | Imperial College London | — |
| Withdrawn | Cardiopulmonary Interactions in Patients With Heart Failure NCT03317314 | Hannover Medical School | — |
| Completed | Treatment of HFpEF With Nitrate Supplement NCT03289481 | MaineHealth | EARLY_Phase 1 |
| Terminated | Adherence to ASV Therapy in Heart Failure With Preserved Ejection Fraction Feasibility Study NCT03195660 | ResMed | N/A |
| Completed | The Heart Failure With Preserved Ejection Fraction (HFpEF) Pathophysiology Study. NCT03186833 | University Hospitals Coventry and Warwickshire NHS Trust | — |
| Completed | LYmphangiogenesis FacTors in Heart Failure States NCT03141567 | Medical University of South Carolina | — |
| Recruiting | Exercise Intolerance in Heart Failure NCT03775577 | Johns Hopkins University | — |
| Active Not Recruiting | Circulating RNAs in Acute Congestive Heart Failure NCT03345446 | Massachusetts General Hospital | — |
| Recruiting | Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure NCT03480633 | Massachusetts General Hospital | — |
| Completed | Pharmacodynamic Effects of Riociguat in Pulmonary Hypertension and Heart Failure With Preserved Ejection Fract NCT02744339 | Medical University of Vienna | Phase 2 |
| Completed | Cell Therapy in HFpEF NCT02923609 | University Medical Centre Ljubljana | Phase 2 |
| Completed | Inspiratory Muscle Training and Functional Electrical Stimulation for Treatment of HFpEF NCT02638961 | Universitat Jaume I | N/A |
| Unknown | WHISH-2-Prevent Heart Failure NCT03099889 | Memorial Hospital of Rhode Island | N/A |
| Completed | Left Ventricular Stiffness vs. Fibrosis Quantification by T1 Mapping in Heart Failure With Preserved Ejection NCT02459626 | Heart Center Leipzig - University Hospital | — |
| Completed | Interleukin-1 Blockade in HF With Preserved EF NCT02173548 | Virginia Commonwealth University | Phase 2 |
| Completed | Effect of Inorganic Nitrates (Beetroot Juice) on Arterial Hemodynamics and Exercise Capacity NCT01919177 | Corporal Michael J. Crescenz VA Medical Center | Phase 2 |
| Completed | Left Ventricular Torsional Hysteresis: A Global Parameter for Diastolic Function NCT01431027 | University of Alabama at Birmingham | — |
| Terminated | ImCardia for DHF to Treat Diastolic Heart Failure (DHF) Patient a Pilot Study NCT01347125 | CorAssist Cadiovascular Ltd. | EARLY_Phase 1 |