| Not Yet Recruiting | Smoking Harm Reduction Using E-cigarettes and Cytisine NCT07274475 | Centre for Addiction and Mental Health | N/A |
| Not Yet Recruiting | Innovating Technology Solutions for Residents in Support Housing Communities w SUD Through Community-Engaged R NCT07001020 | Oregon Research Behavioral Intervention Strategies, Inc. | N/A |
| Not Yet Recruiting | Evaluation of Clinical Decision Support in Opioid Tapering NCT06527079 | University of Colorado, Denver | — |
| Not Yet Recruiting | Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder NCT06526286 | University of Colorado, Denver | — |
| Not Yet Recruiting | Clinical Decision Support for Safety of Opioid Transitions NCT06527040 | University of Colorado, Denver | — |
| Enrolling By Invitation | Testing the Effects of Cann'App, a Digital Intervention for Cannabis Harm Reduction NCT07157540 | Jacques Gaume | N/A |
| Enrolling By Invitation | An Augmented Reality Videogame for Alcohol Use Prevention and Harm Reduction in Teens NCT04351958 | Yale University | N/A |
| Not Yet Recruiting | HARM REDUCTION INTERVENTION FOR PEOPLE WHO USE ANABOLIC ANDROGENIC STEROIDS: THE RANDOMIZED CONTROLLED TRIAL NCT07039539 | University of Sao Paulo | N/A |
| Recruiting | Shelter HArm Reduction Evaluation NCT07170072 | NYU Langone Health | — |
| Terminated | Game-Based Intervention to Reduce Alcohol-Related Harms Among Sexual and Gender Minority Youth NCT06215664 | University of Pittsburgh | N/A |
| Recruiting | Teaching Health Resilience in a Hospital Setting: A Peer-led Intervention NCT06843213 | University of Pennsylvania | N/A |
| Recruiting | Electronic Harm Reduction Treatment for Alcohol NCT06702007 | University of Washington | Phase 3 |
| Recruiting | Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers NCT06372899 | Abramson Cancer Center at Penn Medicine | N/A |
| Active Not Recruiting | Assessment of the Perceptions and Opinions of Staff Working of Prisons and Detention Centers on the Use of Psy NCT06894589 | University Hospital, Brest | — |
| Completed | Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders NCT06554873 | Rose Research Center, LLC | Phase 3 |
| Enrolling By Invitation | Clinical Decision Support to Improve System Naloxone Co-prescribing NCT06271668 | University of Colorado, Denver | — |
| Recruiting | Vending Machine Naloxone Distribution for Your Community (VENDY) NCT06429436 | University of Colorado, Denver | Phase 4 |
| Enrolling By Invitation | Harm Reduction Strategies for Gay, Bisexual and Other Men Who Have Sex With Men Engaging in Chemsex NCT06187415 | National Cheng Kung University | N/A |
| Terminated | Evaluate Harm Reduction Products as a Second Line Intervention for Adult Smokers Who Do Not Quit With NRT NCT06088862 | Rose Research Center, LLC | Phase 3 |
| Recruiting | A Randomized Clinical Trial of a Novel Drug Education and Diversion Program (iDECIDE) for Middle and High Scho NCT06115746 | Massachusetts General Hospital | N/A |
| Completed | Assisting Smokers to Switch to an e-Cigarette by Accelerating Learning of Adaptive Habits Using D-cycloserine NCT05994703 | Rose Research Center, LLC | Phase 2 |
| Recruiting | Our Healthbox - Evaluating Interactive Dispensing Systems for Low-Barrier Access to HIV Testing and Harm Reduc NCT05516069 | Unity Health Toronto | N/A |
| Completed | Evaluation of a Novel Intervention to Prevent Polysubstance Overdoses Involving Illicit Stimulants NCT05493475 | Nationwide Children's Hospital | N/A |
| Active Not Recruiting | Evaluating an Intervention to Prevent Overdoses in Rural and Urban Counties NCT05463341 | Nationwide Children's Hospital | N/A |
| Completed | Switching to Potential Reduced Exposure Products in Adult Smokers NCT04250727 | Yale University | N/A |
| Completed | Implementation of Onsite, Rapid ART Initiation Among People Who Inject Drugs Living With HIV at Syringe Servic NCT04650269 | University of Miami | Phase 4 |
| Completed | Exposure to Plasticisers in the Neonatal Intensive Care Unit NCT05404815 | University Hospital, Antwerp | — |
| Completed | Community-Based, Client-Centered Prevention Homes to Address the Rural Opioid Epidemic- Aim 3 NCT04268173 | University of Wisconsin, Madison | N/A |
| Completed | Life Enhancing Alcohol-management Program NCT04302740 | University of Washington | N/A |
| Completed | Combination of E-cigarettes and Varenicline for Tobacco Harm Reduction NCT04210180 | Rose Research Center, LLC | Phase 2 / Phase 3 |
| Completed | Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes NCT04188197 | Rose Research Center, LLC | N/A |
| Completed | BE Intervention for Naloxone Uptake NCT06064981 | University of Pennsylvania | N/A |
| Unknown | CBD Cigarettes Instead of Normal Cigarettes as Innovative Treatment for Schizophrenia NCT04700930 | Psychiatric Hospital of the University of Basel | N/A |
| Completed | A Usability Assessment of Naloxone Administration by Untrained Community Members NCT04025671 | State University of New York - Upstate Medical University | N/A |
| Completed | The Impact on Linkage-to-care of an Alternative Hepatitis C Screening Method in PWID NCT02971488 | Hospital Universitario Infanta Leonor | — |
| Unknown | Fast Track Module Based Colonoscopy Training Programme for Surgical Trainees at North Jutland Surgical Departm NCT02425657 | Aalborg University Hospital | — |
| Completed | Group-based Intervention for Club Patrons NCT03652688 | Pacific Institute for Research and Evaluation | N/A |
| Terminated | Reducing Hospital Falls by Empowering Nurses to Provide Ambulatory Aids NCT03675503 | Montefiore Medical Center | N/A |
| Completed | Implementation of a Web-based Alcohol and Other Drug Prevention Intervention for Collegiate Student-athletes NCT04253158 | Prevention Strategies, LLC | N/A |
| Completed | Self-harming Behaviors Study of Adolescents in a Juvenile Detention House NCT01130441 | Far Eastern Memorial Hospital | — |
| Completed | In-vivo Extraction of Lead, Cadmium and Tobacco Specific Nitrosamines From Swedish 'Snus' in Regular Snus User NCT01838473 | Contract Research Organization el AB | Phase 1 |
| Completed | In-vivo Extraction of Pb, Cd andTSNA From Swedish Snus NCT01249339 | Contract Research Organization el AB | Phase 1 |
| Completed | In-vivo Extraction of Pb, Cd and TSNA From Swedish Snus NCT01369693 | Contract Research Organization el AB | Phase 1 |