| Completed | Sapphire 3 CTO Study NCT06358508 | OrbusNeich | N/A |
| Recruiting | Calcification on CTCA of a CTO and PCI Outcomes NCT06414551 | Sandwell & West Birmingham Hospitals NHS Trust | — |
| Recruiting | VasoStar Vibrational Guidewire System to Facilitate Crossing Coronary Artery Chronic Total Occlusions NCT06193954 | VasoStar, LLC | N/A |
| Unknown | Coronary Crossing System in Patients With Coronary Chronic Total Occlusions NCT05813704 | Shanghai MicroPort Rhythm MedTech Co., Ltd. | N/A |
| Unknown | Application of Coronary Artery Chronic Total Occlusion Scoring Systems NCT05883579 | Assiut University | — |
| Unknown | Evaluating the Use of the CapBuster System for the Crossing of CTO's in Coronary Arteries NCT05733481 | Praxis Medical Devices Ltd | N/A |
| Unknown | Viable Myocardium Detected by Hybrid PET/MR and SPECT for the Prediction of the Efficacy of PCI in Patients Wi NCT06113835 | The First Affiliated Hospital with Nanjing Medical University | — |
| Completed | Evaluation of Long Coronary Artery Stents With Third-generation Dual-source Computed Tomography Angiography NCT06543641 | Lauri Mansikkaniemi | N/A |
| Completed | Predictors and Long-term Incidence of In-stent Restenosis After Chronic Total Occlusion Percutaneous Coronary NCT07473596 | Lauri Mansikkaniemi | N/A |
| Recruiting | To Evaluate Whether IVUS-guided Drug-eluting Stent (DES) Implantation Leads to Better Clinical Outcomes Compar NCT04944615 | CCRF Inc., Beijing, China | N/A |
| Unknown | Early and Midterm Outcomes of Intravascular Ultrasound (IVUS) Versus Non-IVUS Guidance in Complex Coronary Chr NCT04917432 | Assiut University | N/A |
| Recruiting | CT Coronary Angiography Prior to CTO PCI NCT05364827 | Sandwell & West Birmingham Hospitals NHS Trust | N/A |
| Active Not Recruiting | Invest-CTO PCI Trial NCT04774913 | Haukeland University Hospital | N/A |
| Completed | Holo CTO Proctoring Study NCT05377866 | Sorlandet Hospital HF | — |
| Completed | A Placebo-controlled Trial of Chronic Total Occlusion Percutaneous Coronary Intervention for the Relief of Sta NCT05142215 | Mid and South Essex NHS Foundation Trust | N/A |
| Unknown | DYNAMX Bioadaptor ImplanTation for the trEatment of Complex Coronary Lesions NCT05464147 | Elixir Medical Corporation | N/A |
| Unknown | EvaLuAtion On the cHaracteristics of the True/False lUmen and Its Prognostic Value for cOronary CTO Patients J NCT04965207 | Shanghai 10th People's Hospital | — |
| Unknown | Drug-Coated Balloon Coronary Angioplasty Versus Stenting for Treatment of Disease Adjacent to a Chronic Total NCT04881812 | Amsterdam UMC, location VUmc | N/A |
| Completed | Clinical Evaluation of A New High-speed and High-resolution Intravascular Ultrasound System NCT04739657 | Insight Lifetech Co., Ltd. | — |
| Unknown | Safety and Efficacy of Drug-Coated Balloon Angioplasty for the Treatment of Chronic Total Occlusions NCT04744571 | Beijing Anzhen Hospital | N/A |
| Unknown | Microvascular Coronary Resistance and Absolute Coronary FLOW in Patients With Percutaneous Intervention of a C NCT05197361 | Parc de Salut Mar | — |
| Completed | Chronic Total Occlusion Percutaneous Coronary Intervention Study NCT03988166 | Vascular Solutions LLC | N/A |
| Unknown | Observational Registry on Clinical Outcome After Diagnosis of Chronic Total Occlusions NCT04145167 | Ziekenhuis Netwerk Antwerpen (ZNA) | — |
| Terminated | Cardiac Cath Lab Staff Radiation Exposure NCT03959072 | Corindus Inc. | — |
| Recruiting | Revascularization Versus Optimal Medical Therapy of Chronic Total Coronary Occlusions on Left Ventricular Isch NCT03756870 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Unknown | OCT Explores Vascular Response and Healing Profile After Stenting in CTO NCT03939299 | Shanghai Zhongshan Hospital | N/A |
| Completed | The BLIMP Balloon in Coronary Interventions NCT03947398 | Universitaire Ziekenhuizen KU Leuven | N/A |
| Unknown | Ultrathin DES in Complex PCI Scenarios: the ULTRA a Multicenter Study NCT05205148 | A.O.U. Città della Salute e della Scienza | — |
| Completed | Antegrade and Retrograde Dissection and Re-entry Approach for CTO NCT03769038 | Xijing Hospital | N/A |
| Recruiting | ISCHEMIA-CTO Trial - Revascularisation or Optimal Medical Therapy of CTO NCT03563417 | Aarhus University Hospital Skejby | N/A |
| Completed | Incidence of Ventricular Arrhythmias in Patients With Chronic Total Occlusion Recanalization NCT03475888 | Erasmus Medical Center | N/A |
| Terminated | Safety and Efficacy Study of the SoundBite™ Crossing System With ACTIVE Wire in Coronary CTOs. NCT03521804 | SoundBite Medical Solutions, Inc. | N/A |
| Active Not Recruiting | The NOrdic-Baltic Randomized Registry Study for Evaluation of PCI in Chronic Total Coronary Occlusion NCT03392415 | Leif Thuesen | N/A |
| Unknown | The Success of Opening Concurrent CTO leSion to Improve Cardiac Function Trial in Patients With Multi-vessel D NCT03372785 | Beijing Anzhen Hospital | — |
| Completed | Post-stenting Assessment of Reendothelialization With OFDI After CTO Procedure (PERFECTO) NCT03209843 | Poitiers University Hospital | N/A |
| Recruiting | Evaluation of Effectiveness and Safety of Antegrade and Retrograde Approach of Percutaneous Coronary Intervent NCT03667196 | Seung-Whan Lee, M.D., Ph.D. | — |
| Unknown | CTO Registry From Insight of IVUS in Fuwai Hospital NCT03461367 | China National Center for Cardiovascular Diseases | — |
| Unknown | Properties of Myocardial Microcirculation in Patients With Different Pathomorphological Substrates, Before and NCT04060615 | University of Belgrade | N/A |
| Terminated | REduction of Contrast Via DyeVert Used in CTO Procedures NCT03118544 | Minneapolis Heart Institute Foundation | — |
| Withdrawn | The SHINE-CTO Trial NCT02784418 | Minneapolis Heart Institute Foundation | N/A |
| Completed | A Prospective, Multi-Center, Pivotal Study to Evaluate the Safety and Effectiveness of the NovaCross™ Micro-ca NCT02477579 | Nitiloop Ltd. | N/A |
| Completed | The Impact of Coronary Chronic Total Occlusion Percutaneous Coronary Intervention on Culprit Vessel Physiology NCT03830853 | Mid and South Essex NHS Foundation Trust | — |
| Completed | The XLIMUS-DES in Very Complex Lesions NCT02360020 | Clinica Mediterranea | Phase 4 |
| Completed | CrossBoss and Hybrid Registry on Coronary Chronic Total Occlusions NCT02075372 | Hasselt University | — |
| Unknown | Coronary Interventions Ulm - Coronary Chronic Total Occlusions NCT04650139 | University Hospital Ulm | — |
| Completed | A Prospective, First in Man Study to Evaluate the Safety and Performance of the NovaCross™ Micro-catheter NCT01978860 | Chanan Schneider | N/A |
| Recruiting | Japanese CTO PCI Expert Registry NCT01889459 | Kurashiki Central Hospital | — |
| Completed | ABSORB FIRST is a Registry Designed to Evaluate the Safety and Performance of Absorb Bioresorbable Vascular Sc NCT01759290 | Abbott Medical Devices | — |
| Completed | OPtimized Stenting Using Intravascular Ultrasound(IVUS) in Long lEsion: Rationale for Simplified criteriA NCT01861860 | Centre Chirurgical Marie Lannelongue | N/A |
| Unknown | COronary CoLLateralization in Type 2 diabEtic Patients With Chronic Total Occlusion NCT06054126 | Ruijin Hospital | — |
| Completed | XIENCE V® USA Dual Antiplatelet Therapy (DAPT) Cohort NCT01106534 | Abbott Medical Devices | Phase 4 |