| Not Yet Recruiting | Expression of GLP1 Receptor on Peripheral Blood Mononuclear Cells in Advanced Peripheral Artery Disease: Pavin NCT07340112 | University Hospital, Strasbourg, France | — |
| Not Yet Recruiting | Colchicine in Chronic Limb-Threatening Ischemia NCT07536373 | Shin Kong Wu Ho-Su Memorial Hospital | Phase 3 |
| Not Yet Recruiting | Woundsome Revascularization in Chronic Limb-Threatening Ischemia NCT07488637 | Assiut University | N/A |
| Not Yet Recruiting | ORbital Atherectomy for Lesion Preparation in Patients With Chronic Limb-threatening ischEmia NCT07270562 | Cardiovascular and Interventional Radiological Society of Europe | — |
| Not Yet Recruiting | REsorbable SCaffolds With everolimUs-Elution for the Treatment of Infrapopliteal Artery Disease in Patients Wi NCT07270575 | Cardiovascular and Interventional Radiological Society of Europe | — |
| Not Yet Recruiting | Vessel Recoil in Specific CLTI Populations NCT07465627 | Medical University of Graz | — |
| Recruiting | Safety of Antithrombotic Heparin Proteoglycan Mimetic APAC in Peripheral Arterial Occlusive Disease and Chroni NCT07352800 | Aplagon Oy | Phase 2 |
| Recruiting | Transverse Tibial Transport for Chronic Limb-Threatening Ischemia (CLTI) NCT07175129 | University Hospitals Cleveland Medical Center | N/A |
| Recruiting | Pressure Wire Guidance for Infrapopliteal Artery Interventions NCT06879561 | Yonsei University | N/A |
| Not Yet Recruiting | Outcomes of Atherectomy and Balloon Angioplasty Compared to Conventional Angioplasty in Infra-popliteal Chroni NCT07120555 | Assiut University | N/A |
| Recruiting | Symptomatic and Systemic Atherosclerotic Plaque Activity in Patients With Peripheral Arterial Disease Using No NCT07472049 | University of Edinburgh | — |
| Not Yet Recruiting | Intravascular Ultrasound for Peripheral Artery Disease Revascularization NCT06979284 | Hamilton Health Sciences Corporation | N/A |
| Not Yet Recruiting | Efficacy of the Ranger Drug-Coated Balloon in Treating BTK Lesions in Patients With CLTI NCT07014475 | First Affiliated Hospital, Sun Yat-Sen University | — |
| Recruiting | Revascularization of Single Vesrus Multiple Infrapopliteal Vessels in Chronic Limb Threatening Ischemia NCT07068789 | Sohag University | N/A |
| Recruiting | Bioresorbable Sirolimus-Eluting Scaffold Treatment for Below the Knee Disease NCT06071429 | R3 Vascular Inc. | N/A |
| Recruiting | Angioplasty With Shockwave IVL Catheter System in Femoropopliteal Lesions NCT06713850 | Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology | — |
| Recruiting | Peripheral Bypass Trial for Completion Control NCT06264843 | Medistim ASA | — |
| Active Not Recruiting | Esprit BTK Post-Approval Study NCT06656364 | Abbott Medical Devices | N/A |
| Recruiting | AcoArt Litos PCB Below-the-knee Global Trial NCT06330493 | Acotec Scientific Co., Ltd | N/A |
| Completed | Structured Educational Program vs Standard Care in Pre-surgical Critical Limb Ischemia Patients NCT07201168 | Tulip Medicine | N/A |
| Recruiting | Chronic Wounds and Blood Circulation Detection NCT07330635 | National Health Research Institutes, Taiwan | N/A |
| Enrolling By Invitation | Agreement Study on AI-assisted Smartphone-based Monitoring Tool for Difficult-to-heal Ischemic Leg Ulcers NCT06421961 | Sahlgrenska University Hospital | — |
| Recruiting | Chronic Limb-Threatening Ischemia Treated With Intravascular Lithotripsy Observational Study NCT06149650 | Cardiovascular and Interventional Radiological Society of Europe | — |
| Recruiting | Multimodal Noninvasive Assessment of Peripheral Circulation in Chronic Limb-threatening Ischemia NCT05786001 | Tampere University | — |
| Not Yet Recruiting | Use of CPETarm for Risk Stratification of Patients With CLTI NCT06404229 | University of Manchester | N/A |
| Enrolling By Invitation | Pivotal Trial of the Boomerang Catheter for pDVA NCT06311773 | Aveera Medical, Inc. | N/A |
| Unknown | Observational Study Regarding the Necessity of Inclusion of Foot Arch State Together With the Angiosome Theory NCT06542523 | Ain Shams University | — |
| Unknown | The Role of Glass Stage Compared to WIFI Stage in Predicting Limb Salvage NCT06209866 | Assiut University | — |
| Unknown | Validating GLASS Score in Predicting Acute Limb Events in CLTI Patients NCT06186544 | Cardiff and Vale University Health Board | — |
| Recruiting | The ROAMM-EHR Study NCT06263322 | University of Florida | N/A |
| Recruiting | Thermovision-controlled Lumbar Sympathetic Blockade in Chronic Limb-threatening Ischemia Treatment NCT06111599 | EPC Education s.r.o. | N/A |
| Active Not Recruiting | The PORTuguese Registry of Supera Supported Femoral-Fopliteal Revascularization (SupPORT Registry) NCT06416644 | Hospital do Divino Espírito Santo de Ponta Delgada | N/A |
| Completed | Referrals for CLTI: Qualitative Study NCT05659004 | University of Hull | — |
| Active Not Recruiting | Clinical Outcomes Following Surgical Debridement of Diabetic Foot Infection with Borderline Vascularity NCT05553509 | Assiut University | — |
| Completed | Sarcopenia and Peripheral Artery Disease With Chronic Limb Threatening Ischemia NCT07037979 | Fudan University | — |
| Recruiting | PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening I NCT05313165 | LimFlow, Inc. | N/A |
| Completed | Can a Dedicated Chronic Limb-threatening Ischaemia (CLTI) Clinic Improve Patient Self-reported Quality of Life NCT05613907 | The Leeds Teaching Hospitals NHS Trust | — |
| Unknown | Evaluation of Tissue Perfusion in Peripheral Arterial Disease (EVTI-PAD) NCT05570019 | Medical University Innsbruck | — |
| Unknown | the Gut Microbiome and Metabolomics in Chronic Lower extreMities Threatening Ischemia NCT06220994 | Beijing Tsinghua Chang Gung Hospital | — |
| Completed | Comparison of Outcomes of Patients With Stage IV Chronic Limb-threatening Ischemia and Colorectal Cancer NCT05116696 | Clinical Centre of Serbia | — |
| Recruiting | Durg Coated Balloon Angioplasty in Infrapopliteal Lesions NCT05620095 | Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology | — |
| Completed | Prospective Multicenter Registry on the Endovascular Treatment in Critical Limb Threatening Ischemia With Belo NCT04710420 | Xuanwu Hospital, Beijing | — |
| Unknown | Study of AMG0001 to Improve Ulcer Healing and Perfusion in Subjects With Peripheral Ischemic Ulcers NCT04267640 | AnGes USA, Inc. | Phase 2 |
| Unknown | PROMISE II: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Is NCT03970538 | LimFlow, Inc. | N/A |
| Completed | Bone Marrow Mononuclear Cells vs Mesenchymal Stem Cells in Diabetic Patients With Chronic Limb Ischemia NCT05631444 | Fundación Oftalmológica de Santander Clínica Carlos Ardila Lulle | Phase 1 / Phase 2 |
| Completed | High-frequency SCS in Treatment of Chronic Limb-Threatening Ischemia NCT05322798 | Meshalkin Research Institute of Pathology of Circulation | N/A |
| Completed | PROMISE I Early Feasibility Trial of the LimFlow Stent Graft System NCT03124875 | LimFlow, Inc. | N/A |
| Recruiting | Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease NCT03622359 | Nationwide Children's Hospital | N/A |
| Active Not Recruiting | BGC101 (EnEPC) Autologous Cell Therapy From Patient's Own Blood for Treatment of Critical Limb Ischemia (CLI) NCT02805023 | BioGenCell Ltd. | Phase 1 / Phase 2 |