| Not Yet Recruiting | Distinct Directional Postural Stability Deficits Across Lower Limb Musculoskeletal Disorders NCT07508163 | Cairo University | — |
| Not Yet Recruiting | Comparison of the Effects of Hip and Ankle Focused Progressive Exercise Training on Lower Extremity Function i NCT07319403 | Hacettepe University | N/A |
| Not Yet Recruiting | Neurocognitive Exercises for Ankle Instability NCT06567847 | Istanbul University - Cerrahpasa | N/A |
| Withdrawn | Waterproof Casting Versus Standard Casting for Short Leg Walking Casts NCT04961957 | West Virginia University | N/A |
| Recruiting | Auditory Biofeedback Gait Training Individuals With Chronic Ankle Instability NCT06868316 | University of Kentucky | N/A |
| Not Yet Recruiting | The Applicability of the Cumberland Ankle Instability Tool in Basketball Athletes. NCT06927557 | Hacettepe University | — |
| Completed | Phase III Trial to Evaluate the Efficacy and Safety in Patients With Ankle Sprains. NCT06866613 | Teikoku Seiyaku Co., Ltd. | Phase 3 |
| Active Not Recruiting | Design and Validation of a Mobile Health Application for Home-Based Musculoskeletal Therapy in Ankle Sprain NCT06905418 | Superior University | N/A |
| Not Yet Recruiting | Motor Control Prevention Strategies in Basketball Players NCT06520046 | University of Salamanca | N/A |
| Completed | Evaluation of the Recovery Experienced by Patients After an Ankle Sprain Treated in the Emergency Department o NCT06657937 | Nantes University Hospital | — |
| Recruiting | Spinal and Supraspinal Control in Chronic Ankle Instability NCT06898554 | Ayca Yagcioglu | N/A |
| Recruiting | A Mobile Recovery Guidance App for Children and Young Adults With Acute Ankle Inversion Injuries NCT05785533 | Naveen Poonai | N/A |
| Completed | Comparing Bowen Therapy With Ice to Medical Massage for Acute Ankle Sprain NCT06675006 | Rehabilitation Centre Zivot | — |
| Completed | Electrical Stimulation Effect on Ankle Instability During Walking in Virtual Reality Setup NCT06484712 | University of Delaware | N/A |
| Recruiting | The Effect of Taping on Plantar Pressure Distribution in Players With Chronic Ankle Instability NCT06499935 | Cairo University | N/A |
| Not Yet Recruiting | Comparison of Virtual Reality and Motor Imagery Applications in Patients With Ankle Instability NCT06356818 | Istanbul University - Cerrahpasa | N/A |
| Completed | Combined Effects of Talocrural MWM and Therapeutic US on Pain, Balance and Disability in Athletes With Ankle S NCT06866808 | Riphah International University | N/A |
| Completed | Ankle Injuries, Imaging and Prevention Program Effectiveness in New Army Recruits NCT06469099 | University of Haifa | N/A |
| Unknown | The Effect of Manual Lymphatic Drainage on Acute and Post-acute Ankle Sprain in Athletes NCT06168240 | Sylvia Maher Mohsen Farid Hanna | N/A |
| Unknown | Effect of Eccentric Streching vs IASTM of Gastrocnemius and Soleus Muscles in Athletes With Ankle Sprain NCT06241001 | Riphah International University | N/A |
| Recruiting | Effect of ACL Reconstruction in Biomechanical Properties of Ankle Joint Complex NCT06631690 | Cairo University | N/A |
| Completed | Approach to Ankle Sprains in the Emergency Department NCT06563271 | Ankara Etlik City Hospital | Phase 4 |
| Completed | Effectiveness of Motor Imagery Techniques in the Management of Acute Lateral Ankle Sprains in Soccer Players NCT06464796 | Riphah International University | N/A |
| Completed | Project Hypnos: The Impact of a Brief Hypnosis Intervention on Single-limb Dynamic Balance in People With Chro NCT06390072 | Ohio University | N/A |
| Unknown | Diagnostic Ultrasonography in Physiotherapy NCT05916300 | Petr Routner | — |
| Completed | The Effect of Different Talocrural Joint Mobilization Techniques in Lateral Ankle Sprain NCT06295198 | Bahçeşehir University | N/A |
| Completed | Neuromodulation in Chronic Ankle Instability NCT05680779 | University of Alcala | N/A |
| Unknown | Balance and Proprioception Training Program in Patients With Chronic Ankle Sprains NCT05920044 | Ahram Canadian University | N/A |
| Completed | Cognitive Behavioral Based Physical Therapy for Patients With Chronic Ankle Instability NCT07237581 | Creighton University | N/A |
| Completed | Effects of Neuromuscular Training With K-tape in Footballer With Ankle Sprain NCT06198270 | Riphah International University | N/A |
| Unknown | Development of Chronic Ankle Instability After Acute Ankle Sprain NCT05637008 | Universiteit Antwerpen | — |
| Completed | Impact of Chronic Ankle Instability on Gait Loading Strategy NCT05703828 | Delta University for Science and Technology | — |
| Unknown | Assessment of Return to Work and Functional Results of French Military Personnel After Ankle Ligamentoplasty NCT05562700 | Direction Centrale du Service de Santé des Armées | — |
| Completed | Effects of Closed Chain Exercise Versus Neuromuscular Training on Chronic Ankle Sprain in Football Players NCT05981560 | Riphah International University | N/A |
| Completed | Urdu Version of Identification of Functional Ankle Instability Questionnaire NCT06052657 | University of Lahore | — |
| Completed | Effect of Chronic Ankle Instability on Core Stabilization, Dynamic Balance and Agility NCT05441319 | Yeditepe University | — |
| Completed | The Effect of Balance Training Following STARS on Postural Control NCT05602233 | Bahçeşehir University | N/A |
| Completed | Analysis of Balance and Functional Hop Tests in Athletes With Lower Extremity Injuries by Dual Task Study NCT05484778 | Istanbul University | N/A |
| Completed | Construction and Validation of a Score Evaluating the Residual Instability of the Patient After Ankle Ligament NCT05331365 | Elsan | N/A |
| Completed | How is Calf Muscle Endurance Related to Ankle Injuries in TeamGym Athletes? NCT05323773 | Susanne Beischer | — |
| Unknown | Hyaluronic Acid for Soft Tissue Injuries NCT05278897 | Global Research Solutions | N/A |
| Unknown | Group-based Exercise Training Programs for Military Members With Musculoskeletal Conditions NCT05235152 | Laval University | N/A |
| Completed | Grappler Interference Screw Post-Market Collection of Patient Reported Outcome Measures NCT05190874 | Paragon 28 | — |
| Completed | The Effect of Additional Neurodynamic Intervention in Patients With Chronic Ankle Instability NCT05090423 | National Yang Ming Chiao Tung University | N/A |
| Recruiting | Interest of Ultrasound in the Diagnosis of Severity of Lateral Ankle Sprain NCT04846712 | Centre Hospitalier Universitaire de Saint Etienne | — |
| Completed | Osteopathic Consultation in the Emergency Department for Fresh Lateral Ligament Sprain NCT04999254 | CHU de Reims | N/A |
| Recruiting | Comparison of MBR + Suture Tape, MBR, and Anatomic Reconstruction for CLAI in GJL Cases: A Prospective Cohort NCT05698446 | Peking University Third Hospital | — |
| Active Not Recruiting | Ankle Instability Using Foot Intensive Rehabilitation NCT04493645 | Matthew Hoch | N/A |
| Unknown | Urdu Version Of Cumberland Ankle Instability Tool: Reliability And Validity Study NCT05412186 | Riphah International University | — |
| Unknown | Validation of the Identification of Functional Ankle Instability (IdFAI) in Italian NCT04516980 | University of Padova | — |
| Completed | Grappler® Interference Screw Post-Market Clinical Follow-Up Study NCT04893824 | Paragon 28 | — |
| Completed | Fear of Movement, Functionality and Quality of Life in Elite Athletes With an Ankle Instability History NCT04789369 | Acibadem University | — |
| Completed | Italian Version of The Cumberland Ankle Instability Tool (CAIT) NCT04644601 | University of Bologna | — |
| Completed | Telehealth Delivered Physical Rehabilitation for an Ankle Sprain NCT04520854 | Kyle Kosik | N/A |
| Completed | Efficacy of Balance Training by BBS on Gait Parameters and Balance in Patients With RLAS NCT04773990 | MTI University | N/A |
| Completed | Foam Rolling and Tissue Flossing of the Cuff Muscles NCT04367532 | Wroclaw University of Health and Sport Sciences | N/A |
| Terminated | Effectiveness of Transcranial Direct Current Stimulation (tDCS). NCT04902274 | Keller Army Community Hospital | N/A |
| Unknown | Functional Electrical Stimulation in Chronic Ankle Instability NCT04314960 | Shmuel Springer | N/A |
| Completed | Manual Therapy, Kinesiotape and Strength Training in Soccer Players With Recurrent Ankle Sprains NCT04257916 | Investigación en Hemofilia y Fisioterapia | N/A |
| Terminated | Smartphone App to Improve Functional Outcomes in Ankle Sprains NCT03564015 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Recruiting | The Clinical Outcomes of the Modified Broström vs Anatomic Reconstruction Operation in CLAI and GJL NCT05196906 | Peking University Third Hospital | — |
| Recruiting | Addressing Neuromuscular Deficits for Improved Outcomes in Ankle Rehabilitation NCT03663361 | Phillip Gribble | N/A |
| Completed | The Efficacy of Hypertonic Dextrose Injection to Anterior Talofibular Ligament Sprain NCT03868995 | Taipei Medical University WanFang Hospital | N/A |
| Completed | Follow up of Patients After a Visit to Tourcoing Emergency Department for an Ankle Sprain NCT04114552 | University Hospital, Lille | — |
| Recruiting | Arthroscopic Versus Open Brostrom for Ankle Instability NCT03643926 | Federal University of São Paulo | N/A |
| Unknown | The Immediate Effects of Applying Dynamic Tape, Kinesio Tape and Sport Tape With Chronic Ankle Instability NCT03815526 | Taipei Medical University WanFang Hospital | N/A |
| Unknown | Effects of Mobilization Versus Manipulation on Function in Participants Reporting CAI NCT03918473 | Shenandoah University | N/A |
| Completed | Effects of the Elastic Taping on the Chronic Ankle Instability NCT04568577 | Universidade Norte do Paraná | N/A |
| Completed | The Effects of Unilateral Balance Training Among Athletes With Chronic Ankle Instability NCT04139044 | Yeditepe University | N/A |
| Completed | Evaluation of Ankle Propriocement and Stability NCT04362488 | Istituto Ortopedico Rizzoli | N/A |
| Unknown | inStability Treated With Ligament RecOnstruction Augmented With iNternal bracinG NCT03472404 | Walter van der Weegen | N/A |
| Completed | App-based Exercise Intervention for Persons With Acute Ankle Sprain NCT03550274 | Hvidovre University Hospital | N/A |
| Unknown | Management of Acute Lateral Ankle Sprains NCT03527121 | Christian Olsen | N/A |
| Completed | Efficacy of Kinesio Taping and Splinting in Ankle Sprain NCT03634280 | Istanbul Bilgi University | N/A |
| Completed | Progressing Ankle Brace Restriction on Walking and Running Gait Characteristics in Healthy Individuals NCT03641066 | Sport and Spine Rehab Clinical Research Foundation | N/A |
| Unknown | Clinical Study on the Treatment of Chronic Instability of the Lateral Ankle Joint by Repairing the Anterior Ta NCT04736238 | Peking University People's Hospital | N/A |
| Unknown | Effects of Gait Biofeedback and Impairment-based Rehabilitation in Individuals With Chronic Ankle Instability NCT03507803 | University of Virginia | Phase 3 |
| Unknown | Effect of Mobilization in Conjunction With Exercise in Participants With a History of Chronic Ankle Instabilit NCT03428620 | Shenandoah University | N/A |
| Completed | Evaluation of Proprioception in Patients Treated With Surgical External Ankle Ligament Recontruction for Traum NCT05868681 | Istituto Ortopedico Rizzoli | N/A |
| Completed | The Clinical Outcomes of the Arthroscopic and Open Modified Broström Operation in CLAI and GJL NCT05284188 | Peking University Third Hospital | N/A |
| Completed | The Evaluation of Ankle Joint Braces Efficiency NCT04586036 | Barbara Łysoń | N/A |
| Withdrawn | Agreement Between Clinician and Instrumented Laxity Assessment NCT03309098 | University of Nebraska | — |
| Completed | A Study Investigating The Effects Of An Ankle Rehabilitation Program On High School Athletes With Ankle Instab NCT03447652 | Georgia State University | N/A |
| Completed | Ankle Taping and Functional Ankle Instability NCT03626051 | National Yang Ming Chiao Tung University | N/A |
| Unknown | Comparison Between Two Mobilization Techniques of Ankle on Balance in Patients With Chronic Ankle Instability NCT03079804 | Universidade Federal do Ceara | N/A |
| Completed | Effects of Two Supervised Training Programs for the Rehabilitation of Ankle Sprains NCT01853462 | Lazaros Lazarou | N/A |
| Completed | Effects of Manual Therapy and Exercise in the Treatment of Ankle Sprains NCT02252276 | University of Alcala | N/A |
| Terminated | Chiropractic Care and a Specific Regimen of Nutritional Supplementation for Patients With Acute Ankle Sprain NCT01824095 | Logan University, Inc. | Phase 3 |
| Completed | Accumulative Effects of Talus Mobilization NCT02244008 | Federal University of Minas Gerais | N/A |
| Completed | MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Ankle Sprains NCT01198834 | MEDRx USA, Inc. | Phase 3 |