Clinical Trials Directory

Trials / Conditions / Anatomic Stage IV Breast Cancer AJCC v8

Anatomic Stage IV Breast Cancer AJCC v8

130 registered clinical trials studyying Anatomic Stage IV Breast Cancer AJCC v849 currently recruiting.

StatusTrialSponsorPhase
RecruitingTesting the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-
NCT07137416
National Cancer Institute (NCI)Phase 1
Not Yet RecruitingTesting the Safety of the Anti-cancer Drug, Sn-117m-DTPA, for Advanced Cancers That Have Spread to Bones
NCT06982222
National Cancer Institute (NCI)Phase 1
WithdrawnVirtual Mental Health Intervention to Address Fear of Progression for Women With High Risk or Stage III-IV Gyn
NCT07226102
City of Hope Medical CenterN/A
RecruitingCemiplimab and Transarterial Radioembolization With Y-90 SIR-S Spheres for the Treatment of Liver Directed Met
NCT06860815
City of Hope Medical CenterPhase 2
Not Yet RecruitingPropranolol and Pembrolizumab for Tumor Re-sensitization and Treatment of Patients With Checkpoint Inhibitor R
NCT05741164
Emory UniversityPhase 2
RecruitingA Cancer Vaccine (STEMVAC) in Combination With Chemotherapy for the Treatment of PD-L1 Negative Metastatic Tri
NCT07078604
University of WashingtonPhase 2
RecruitingTamoxifen and Pegylated Liposomal Doxorubicin for the Treatment of Patients With Metastatic or Inoperable, Loc
NCT06434064
Roswell Park Cancer InstitutePhase 2
Recruiting[18F]FTT Positron Emission Tomography for the Measurement of PARP Tumor Expression in Patients With Metastatic
NCT06502691
University of WashingtonPhase 1 / Phase 2
RecruitingLeuprolide and Goserelin for Ovarian Function Suppression in Pre- or Peri-menopausal Women With Breast Cancer,
NCT07158021
University of Michigan Rogel Cancer CenterPhase 2
RecruitingLiving Well With Advanced Breast Cancer
NCT07227038
Ohio State University Comprehensive Cancer Center
RecruitingPersonalized Vaccine Immunotherapy in Combination With Checkpoint Inhibitor for Treatment of Triple Negative B
NCT06324240
Emory UniversityPhase 1
Not Yet Recruiting177Lu-DOTATATE for the Treatment of Stage IV or Recurrent Breast Cancer
NCT04529044
OHSU Knight Cancer InstitutePhase 2
RecruitingA Vaccine (STEMVAC) With Standard Endocrine-Based Therapy or Chemotherapy for the Treatment of Metastatic Horm
NCT07112053
University of WashingtonPhase 2
RecruitingHigh Dose Radiation Therapy With Pembrolizumab and Chemotherapy for the Treatment of Patients With PD-L1 Posit
NCT06492759
Emory UniversityPhase 2
RecruitingAdaptive Therapy With Capecitabine for Treatment of Metastatic ER Positive, HER2 Negative Breast Cancer
NCT06525766
Mayo ClinicPhase 2
RecruitingAn Optimized Ultrasound Twinkling Marker for the Imaging of Lymph Nodes in Patients With Clinically Node-Posit
NCT06999798
Mayo ClinicPhase 1
WithdrawnTesting the Addition of an Investigational Anti-Cancer Drug, ASTX660 (Tolinapant), to a Usual Chemotherapy Tre
NCT06590558
National Cancer Institute (NCI)Phase 1
Active Not RecruitingA Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Brea
NCT06630325
OHSU Knight Cancer InstitutePhase 2
RecruitingPhoton Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-
NCT06910761
City of Hope Medical CenterPhase 2
RecruitingTesting Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis
NCT06500481
NRG OncologyPhase 3
RecruitingHippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast C
NCT06518057
University of WashingtonPhase 2
WithdrawnDendritic Cell-Based Treatment Plus Immunotherapy for the Treatment of Metastatic or Unresectable Triple Negat
NCT05539365
Roswell Park Cancer InstitutePhase 2
RecruitingTesting Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has
NCT06500455
NRG OncologyPhase 3
TerminatedTesting the Use of Fulvestrant and Binimetinib Targeted Treatment for NF1 Mutation in Hormone Receptor-Positiv
NCT05554354
National Cancer Institute (NCI)Phase 2
CompletedMBC Physical Activity Study
NCT06500858
Thomas Jefferson UniversityN/A
RecruitingStereotactic Body Radiation Therapy and FES PET/CT Imaging for the Treatment of Oligoprogressive Estrogen Rece
NCT06260033
City of Hope Medical CenterPhase 2
RecruitingFunctional Imaging in Prediction of Response to Abemaciclib for Advanced Hormone Receptor-Positive, HER2-Negat
NCT06179303
University of WashingtonPhase 2
RecruitingGemcitabine and Ex Vivo Expanded Allogenic Universal Donor, TGFβi Natural Killer (NK) Cells With or Without Na
NCT06026657
Margaret Gatti-MaysPhase 1 / Phase 2
WithdrawnTesting the Addition of Immunotherapy With Hu5F9-G4 (Magrolimab) to the Usual PARP Inhibitor, Olaparib for Tre
NCT05807126
National Cancer Institute (NCI)Phase 1
TerminatedRintatolimod, Celecoxib and Interferon Alpha 2b With Pembrolizumab For the Treatment of Patients With Metastat
NCT05756166
Roswell Park Cancer InstitutePhase 1 / Phase 2
RecruitingMobile Health for Adherence in Breast Cancer Patients
NCT06112613
ECOG-ACRIN Cancer Research GroupN/A
TerminatedAn Interactive Time-Restricted Diet Intervention (txt4fasting) for Reducing Neurocognitive Decline and Improvi
NCT06315296
Thomas Jefferson UniversityN/A
SuspendedFinding an Effective Dose of GM1 to Reduce or Prevent Neuropathy (Numbness or Weakness) Due to Treatment With
NCT05751668
Alliance for Clinical Trials in OncologyPhase 2
WithdrawnOlaparib and Alpelisib for Treatment of Metastatic Breast Cancer, A ComboMATCH Treatment Trial
NCT05967286
National Cancer Institute (NCI)Phase 2
RecruitingPrimary Breast Oligoprogressive Sites Treated With Radiotherapy to Obviate the Need to Change Systemic Therapy
NCT06055881
Mayo ClinicN/A
RecruitingIvermectin in Combination With Balstilimab or Pembrolizumab in Patients With Metastatic Triple Negative Breast
NCT05318469
Yuan YuanPhase 1 / Phase 2
RecruitingTesting the Addition of an Anti-cancer Drug, ASTX727 (Cedazuridine, Decitabine), to Chemotherapy (Paclitaxel)
NCT05673200
National Cancer Institute (NCI)Phase 1
CompletedTka Assay for CDK4/6i
NCT06572800
Yale UniversityN/A
RecruitingTesting the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Ad
NCT05372640
National Cancer Institute (NCI)Phase 1
WithdrawnZN-c3 for the Treatment of Metastatic Triple-Negative Breast Cancer and Advanced Ovarian Cancer
NCT05368506
OHSU Knight Cancer InstituteEARLY_Phase 1
RecruitingThe Immune Effects of Fermented Wheat Germ Nutritional Supplementation in Patients With Advanced Solid Tumor C
NCT05967533
University of California, DavisPhase 1
RecruitingTesting the Addition of Anti-Cancer Drug, ZEN003694 (ZEN-3694) and PD-1 Inhibitor (Pembrolizumab), to Standard
NCT05422794
National Cancer Institute (NCI)Phase 1
RecruitingTumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or L
NCT05746325
Mayo ClinicN/A
RecruitingTargeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumo
NCT05564377
National Cancer Institute (NCI)Phase 2
RecruitingTopical or Oral Minoxidil for the Treatment of Endocrine Therapy-Induced Alopecia in Patients With Stage I-IV
NCT05417308
Ohio State University Comprehensive Cancer CenterEARLY_Phase 1
WithdrawnSMMART Adaptive Clinical Treatment (ACT) Trial
NCT05238831
OHSU Knight Cancer InstituteEARLY_Phase 1
Active Not RecruitingIn Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable a
NCT04616248
University of Southern CaliforniaPhase 1
RecruitingAn Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brai
NCT05376878
City of Hope Medical CenterPhase 4
RecruitingDendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple
NCT04348747
Roswell Park Cancer InstitutePhase 2
WithdrawnPortable Scalp Cooling System for the Improvement of Chemotherapy-Induced Hair Loss in Patients With Metastati
NCT05533320
City of Hope Medical CenterN/A
WithdrawnSGT-53, Carboplatin, and Pembrolizumab for the Treatment of Metastatic Triple Negative Inflammatory Breast Can
NCT05093387
Northwestern UniversityPhase 1
TerminatedTesting an Omega-3 Fatty Acid-Based Anti-Cancer Therapy for Patients With Triple-Negative Inflammatory Breast
NCT05198843
National Cancer Institute (NCI)Phase 1 / Phase 2
WithdrawnRadioembolization of Metastatic Breast Cancer to the Liver as a 2nd/3rd Line Therapy
NCT05315687
Emory UniversityPhase 2
WithdrawnEffects of Ribociclib and Palbociclib on Tumor and Blood Characteristics in Patients With Metastatic Breast Ca
NCT05244434
City of Hope Medical CenterN/A
RecruitingPersonalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma, Hormone Receptor Positiv
NCT05098210
Fred Hutchinson Cancer CenterPhase 1
RecruitingPhase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Pa
NCT05092373
M.D. Anderson Cancer CenterPhase 1
RecruitingRibociclib, Tucatinib, and Trastuzumab for the Treatment of HER2 Positive Breast Cancer
NCT05319873
Jonsson Comprehensive Cancer CenterPhase 1 / Phase 2
RecruitingPersonalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Soli
NCT05269381
Mayo ClinicPhase 1 / Phase 2
Active Not RecruitingA Video Intervention to Improve Patient Understanding of Tumor Genomic Testing in Patients With Metastatic Can
NCT05215769
Ohio State University Comprehensive Cancer CenterN/A
WithdrawnPanitumumab and Pembrolizumab in Combination With Neoadjuvant Chemotherapy for the Treatment of Stage III-IV T
NCT05177796
M.D. Anderson Cancer CenterPhase 2
CompletedEvaluation of Barriers to Cancer Care Delivery and Outcomes for Women of Color With Metastatic Breast Cancer
NCT06206239
Thomas Jefferson University
Active Not RecruitingTesting the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced
NCT04514484
National Cancer Institute (NCI)Phase 1
Active Not RecruitingCF33-hNIS-antiPDL1 for the Treatment of Metastatic Triple Negative Breast Cancer
NCT05081492
City of Hope Medical CenterPhase 1
Active Not RecruitingNiraparib and TSR-042 for the Treatment of BRCA-Mutated Unresectable or Metastatic Breast, Pancreas, Ovary, Fa
NCT04673448
University of WashingtonPhase 1
CompletedSafely Stopping Pre-medications in Patients With Breast Cancer Who Are Receiving Paclitaxel
NCT04862585
Ohio State University Comprehensive Cancer CenterPhase 2 / Phase 3
Active Not RecruitingTesting the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or C
NCT04491942
National Cancer Institute (NCI)Phase 1
RecruitingTesting the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tu
NCT04704661
National Cancer Institute (NCI)Phase 1
TerminatedComparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery
NCT04588246
NRG OncologyPhase 3
TerminatedGenetically Engineered Cells (MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells) and Atezolizumab
NCT04639245
Fred Hutchinson Cancer CenterPhase 1 / Phase 2
CompletedFluciclovine and PSMA PET/CT for the Classification and Improved Staging of Invasive Lobular Breast Cancer
NCT04750473
Emory UniversityPhase 1
Active Not RecruitingTesting Sacituzumab Govitecan Therapy in Patients With HER2-Negative Breast Cancer and Brain Metastases
NCT04647916
SWOG Cancer Research NetworkPhase 2
TerminatedTesting the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Maintenance Treatment (Trastuzumab and P
NCT04108858
National Cancer Institute (NCI)Phase 1 / Phase 2
RecruitingMeasuring the Effects of Talazoparib in Patients With Advanced Cancer and DNA Repair Variations
NCT04550494
National Cancer Institute (NCI)Phase 2
RecruitingTesting the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients
NCT03606967
National Cancer Institute (NCI)Phase 2
WithdrawnAbexinostat, Palbociclib, and Fulvestrant for the Treatment of Breast or Gynecologic Cancer
NCT04498520
Pamela MunsterPhase 1
TerminatedPembrolizumab and Tamoxifen With or Without Vorinostat for the Treatment of Estrogen Receptor Positive Breast
NCT04190056
University of California, San FranciscoPhase 2
WithdrawnImmunotherapy (NHS-IL12 & Bintrafusp Alfa) and Radiation Therapy for the Treatment of Hormone Receptor Positiv
NCT04756505
M.D. Anderson Cancer CenterPhase 1
Active Not RecruitingTesting the Addition of Copanlisib to Eribulin in Metastatic Triple Negative Breast Cancer
NCT04345913
National Cancer Institute (NCI)Phase 1 / Phase 2
Completed18F-FMAU PET/CT and MRI for the Detection of Brain Tumors in Patients With Brain Cancer or Brain Metastases
NCT04752267
University of Southern CaliforniaEARLY_Phase 1
RecruitingAvapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Sol
NCT04771520
M.D. Anderson Cancer CenterPhase 2
TerminatedBintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain Metastases
NCT04789668
M.D. Anderson Cancer CenterPhase 1 / Phase 2
WithdrawnBreast Cancer Vaccine in Combination With Pembrolizumab for Treatment of Persistent, Recurrent, or Metastatic
NCT04418219
Thomas Jefferson UniversityPhase 1 / Phase 2
CompletedNipple Aspirate Fluid in Detecting Breast Cancer
NCT03715959
Ohio State University Comprehensive Cancer CenterN/A
SuspendedOptimizing Treatment of Stage IV Breast Cancer Through Real-Time Disease Monitoring
NCT04906369
Mayo Clinic
Active Not RecruitingNational Cancer Institute "Cancer Moonshot Biobank"
NCT04314401
National Cancer Institute (NCI)
WithdrawnT-DM1 With or Without Abemaciclib for the Treatment of HER2-Positive Metastatic Breast Cancer
NCT04351230
Academic and Community Cancer Research UnitedPhase 2
WithdrawnLorcaserin in Treating Chemotherapy-Induced Peripheral Neuropathy in Patients With Stage I-IV Gastrointestinal
NCT04205071
Ohio State University Comprehensive Cancer CenterPhase 1
RecruitingA Vaccine (MV-s-NAP) for the Treatment of Patients With Invasive Metastatic Breast Cancer
NCT04521764
Mayo ClinicPhase 1
Active Not RecruitingUsing FDG-PET/CT to Assess Response of Bone-Dominant Metastatic Breast Cancer, FEATURE Study
NCT04316117
ECOG-ACRIN Cancer Research GroupPhase 2
Active Not RecruitingTesting the Addition of Radium Therapy (Radium-223 Dichloride) to the Usual Chemotherapy Treatment (Paclitaxel
NCT04090398
National Cancer Institute (NCI)Phase 2
RecruitingImmune Response to Anti-HER2 Therapies in Patients With HER2-Positive Stage I-IV Breast Cancer
NCT04517838
Mayo Clinic
RecruitingOlaparib With Cediranib or AZD6738 for the Treatment of Advanced or Metastatic Germline BRCA Mutated Breast Ca
NCT04090567
M.D. Anderson Cancer CenterPhase 2
Active Not RecruitingINCMGA00012 and Pelareorep for the Treatment of Metastatic Triple Negative Breast Cancer, IRENE Study
NCT04445844
Mridula George, MDPhase 2
RecruitingBiomarkers and Clinical Features of Metastatic Breast Cancer in Patients Treated With CDK4/6 Inhibitors
NCT04526587
Roswell Park Cancer Institute
Active Not RecruitingTesting the Addition of Copanlisib to Usual Treatment (Fulvestrant and Abemaciclib) in Metastatic Breast Cance
NCT03939897
National Cancer Institute (NCI)Phase 1
SuspendedAlpha-TEA and Trastuzumab for the Treatment of Refractory HER2+ Metastatic Breast Cancer
NCT04120246
Veana TherapeuticsPhase 1
TerminatedSerial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial
NCT03878524
OHSU Knight Cancer InstitutePhase 1
RecruitingAbemaciclib and Endocrine Therapy in Older Patients With Breast Cancer.
NCT04305834
City of Hope Medical CenterPhase 2
CompletedT-VEC With Chemotherapy or Endocrine Therapy in Treating Participants With HER2- Negative Breast Cancer
NCT03554044
University of California, San FranciscoPhase 1
WithdrawnCryoablation, Atezolizumab/Nab-paclitaxel for Locally Advanced or Metastatic Triple Negative Breast Cancer
NCT04249167
Mayo ClinicEARLY_Phase 1
SuspendedPaclitaxel Therapeutic Drug Monitoring in Cancer Patients
NCT03987555
Wake Forest University Health Sciences
SuspendedClinical Information and Biospecimen Collection From Patients With Recurrent or Stage IV Breast Cancer
NCT03737695
Mayo Clinic
Active Not RecruitingEstradiol in Treating Patients With ER Beta Positive, Triple Negative Locally Advanced or Metastatic Breast Ca
NCT03941730
Mayo ClinicPhase 2
CompletedGenetic Analysis of Blood and Tissue Samples From Patients With Advanced Cancer, Moonshot Study
NCT03707574
National Cancer Institute (NCI)
CompletedAlpelisib and Enzalutamide in Treating Patients With Androgen Receptor and PTEN Positive Metastatic Breast Can
NCT03207529
M.D. Anderson Cancer CenterPhase 1
CompletedPharmacogenomics Testing in the Optimal Use of Supportive Care Medications in Stage III-IV Cancer
NCT04067960
Mayo ClinicEARLY_Phase 1
TerminatedAromatase Inhibitor Therapy With or Without Fulvestrant for the Treatment of HR Positive Metastatic Breast Can
NCT04256941
M.D. Anderson Cancer CenterPhase 2
TerminatedKetoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases
NCT03796273
Wake Forest University Health SciencesEARLY_Phase 1
CompletedIpatasertib in Combination With Carboplatin, Carboplatin/Paclitaxel, or Capecitabine/Atezolizumab in Treating
NCT03853707
City of Hope Medical CenterPhase 1 / Phase 2
RecruitingIntravital Microscopy in Human Solid Tumors
NCT03823144
Mayo ClinicN/A
WithdrawnA Study of a New Drug Combination, Copanlisib and Fulvestrant, in Advanced Breast Cancer
NCT03803761
National Cancer Institute (NCI)Phase 1 / Phase 2
CompletedRadiation Therapy, Palbociclib, and Hormone Therapy in Treating Breast Cancer Patients With Bone Metastasis
NCT03691493
Emory UniversityPhase 2
CompletedBreast Cancer Pathways Program Impact on Patient Shared Decision Making and Experience in Academic and Communi
NCT04297384
Roswell Park Cancer InstituteN/A
TerminatedAMTEC IIT: Phase 2 Multiarm Study in TNBC
NCT03801369
Gordon Mills, MD, PhDPhase 2
Active Not RecruitingPI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutati
NCT03218826
National Cancer Institute (NCI)Phase 1
RecruitingS1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative
NCT03723928
SWOG Cancer Research NetworkN/A
CompletedHydroxychloroquine, Palbociclib, and Letrozole Before Surgery in Treating Patients With Estrogen Receptor Posi
NCT03774472
M.D. Anderson Cancer CenterPhase 1 / Phase 2
TerminatedM7824 and Eribulin Mesylate in Treating Patients With Metastatic Triple Negative Breast Cancer
NCT03579472
M.D. Anderson Cancer CenterPhase 1
CompletedOlaparib and Durvalumab in Treating Participants With Metastatic Triple Negative Breast Cancer
NCT03544125
OHSU Knight Cancer InstitutePhase 1
CompletedRadiation Therapy and M7824 in Treating Patients With Metastatic Hormone Receptor Positive, HER2 Negative Brea
NCT03524170
M.D. Anderson Cancer CenterPhase 1
CompletedIACS-010759 in Advanced Cancers
NCT03291938
M.D. Anderson Cancer CenterPhase 1
Active Not RecruitingTVB-2640 and Trastuzumab With Paclitaxel or Endocrine Therapy for Treatment of HER2 Positive Metastatic Breast
NCT03179904
Mayo ClinicPhase 2
CompletedMirvetuximab Soravtansine as First Line in Treating Patients With Triple Negative Breast Cancer
NCT03106077
M.D. Anderson Cancer CenterPhase 2
Active Not RecruitingTesting Olaparib Either Alone or in Combination With Atezolizumab in BRCA Mutant Non-HER2-positive Breast Canc
NCT02849496
National Cancer Institute (NCI)Phase 2
Active Not RecruitingEntinostat, Nivolumab, and Ipilimumab in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be
NCT02453620
National Cancer Institute (NCI)Phase 1
CompletedTesting Whether Treating Breast Cancer Metastases With Surgery or High-Dose Radiation Improves Survival
NCT02364557
NRG OncologyPhase 2 / Phase 3
Active Not RecruitingExemestane With or Without Entinostat in Treating Patients With Recurrent Hormone Receptor-Positive Breast Can
NCT02115282
National Cancer Institute (NCI)Phase 3
Active Not RecruitingGenetic Testing in Predicting Tumor Response in Patients With Stage I-III HER2 Negative Invasive Breast Cancer
NCT01334021
M.D. Anderson Cancer CenterPhase 2
CompletedVeliparib With or Without Carboplatin in Treating Patients With Stage III or IV Breast Cancer
NCT01149083
National Cancer Institute (NCI)Phase 2
CompletedLetrozole and Imatinib Mesylate in Treating Postmenopausal Participants With Estrogen or Progesterone Positive
NCT00338728
M.D. Anderson Cancer CenterPhase 2