| Not Yet Recruiting | This Study Evaluates the Safety, Target Engagement, and Preliminary Efficacy of Galunisertib (TGF-βR1/ALK5 Inh NCT07321860 | Gipfel Life Sciences GmbH | Phase 2 / Phase 3 |
| Not Yet Recruiting | Invasive Home Ventilation in Denmark NCT07467187 | Rigshospitalet, Denmark | — |
| Not Yet Recruiting | Characterization of Platelet Molecular Profiles in ALS for the Identification of Specific Diagnostic Biomarker NCT07479017 | University Hospital, Tours | — |
| Not Yet Recruiting | Virtual Reality for Anxiety Management in Persons With Amyotrophic Lateral Sclerosis NCT07473765 | Horizon Health Network | N/A |
| Not Yet Recruiting | Healey ALS MyMatch Common Screening Protocol NCT07400393 | Massachusetts General Hospital | — |
| Recruiting | Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic Disorders NCT07509125 | Universitaire Ziekenhuizen KU Leuven | N/A |
| Not Yet Recruiting | Kamlanoflast In Amyotrophic Lateral Sclerosis NCT07396818 | Inflammasome Therapeutics | Phase 1 / Phase 2 |
| Recruiting | Safety and Tolerability Study of CTx1000 In Participants With Amyotrophic Lateral Sclerosis NCT07401121 | Celosia Therapeutics Pty Ltd | Phase 1 |
| Recruiting | Clinical Outcome Assessment for AT & BCI NCT07407725 | Shirley Ryan AbilityLab | N/A |
| Not Yet Recruiting | Tongue-strengthening Exercises in People With ALS. NCT07295990 | Nova Southeastern University | N/A |
| Recruiting | Tofersen in Non-SOD1 ALS NCT07294144 | Washington University School of Medicine | Phase 2 |
| Not Yet Recruiting | Augmented Reality BCI Longitudinal Study for Persons With ALS, Stroke, TBI and SCI Utilizing Cognixion + Apple NCT07209943 | Cognixion | N/A |
| Not Yet Recruiting | A Study to Evaluate the Efficacy and Safety of Different Doses of CB03-154 in Adult Patients With Amyotrophic NCT07082192 | Shanghai Zhimeng Biopharma, Inc. | Phase 2 / Phase 3 |
| Recruiting | A Study of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis NCT07100119 | Eli Lilly and Company | Phase 1 |
| Recruiting | Non-invasive Brain Stimulation and Exercise Intervention for Patients With Motor Neuron Disease NCT07067229 | Chulalongkorn University | N/A |
| Not Yet Recruiting | Extended Study of RAG-17 in the Treatment of Amyotrophic Lateral Sclerosis Patients With SOD1 Gene Mutation NCT07077668 | Beijing Tiantan Hospital | EARLY_Phase 1 |
| Not Yet Recruiting | Systems Biology of Amyotrophic Lateral Sclerosis (ALS) NCT07007390 | Viome | — |
| Active Not Recruiting | Trial of Oral Digoxin in Individuals With Amyotrophic Lateral Sclerosis (ALS) NCT07047209 | Massachusetts General Hospital | Phase 2 |
| Recruiting | At-home Treatment With Cortico-spinal tDCS for Amyotrophic Lateral Sclerosis NCT07006571 | University of Trieste | N/A |
| Active Not Recruiting | Obi Medical Robot: Evaluating Effectiveness Related to Usability NCT07151950 | Desin LLC | — |
| Not Yet Recruiting | Psilocybin Therapy for Psychological Distress in Palliative Patients NCT06782724 | University Medical Center Groningen | Phase 2 |
| Recruiting | Amyotrophic Lateral Sclerosis Registry in Thailand NCT07175935 | Chulalongkorn University | — |
| Recruiting | Omics Sciences for the Identification of Pathogenetic Mechanisms and Biomarkers in Neurodegenerative Diseases NCT07235111 | Ospedale Policlinico San Martino | — |
| Recruiting | Disease Biosignatures in ALS/FTD Spectrum: New Impactful Biological Perspectives Beyond Clinical Approaches NCT06856850 | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | — |
| Recruiting | Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study NCT06649955 | PathMaker Neurosystems Inc. | N/A |
| Recruiting | Augmented Reality BCI Longitudinal Study for Persons With Late Stage ALS NCT06810219 | Cognixion | N/A |
| Recruiting | Evaluation of a Structurally Suitable Neck Exoskeleton in Patients With Amyotrophic Lateral Sclerosis NCT07491562 | University of Utah | N/A |
| Recruiting | The Effect of a Muscle-mimicking, Fabric-type Shoulder Orthosis on Functional Movements of the Upper Limb in P NCT06363357 | Seoul National University Hospital | N/A |
| Suspended | Atalante Exoskeleton in the Rehabilitation of Patients With Amyotrophic Lateral Sclerosis NCT06199284 | Institut de Recherche sur la Moelle épinière et l'Encéphale | N/A |
| Completed | Comprehensive Biomarker Profiling of the IFN-α Pathway in Amyotrophic Lateral Sclerosis Patient Biofluids NCT07260981 | Ulysses Neuroscience LTD | — |
| Completed | Home-based Remote Digital Monitoring to Assess ALS Progression (Track ALS) NCT05276349 | St. Joseph's Hospital and Medical Center, Phoenix | — |
| Unknown | Clinical Trial on the Use of Cell Therapy in the Treatment of Patients With Amyotrophic Lateral Sclerosis NCT04849065 | Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia | Phase 2 |
| Completed | Ciprofloxacin/Celecoxib Combination in Patients With ALS NCT04090684 | NeuroSense Therapeutics Ltd. | Phase 1 |
| Active Not Recruiting | T-regulatory Cells in ALS NCT04055623 | The Methodist Hospital Research Institute | Phase 2 |
| Unknown | Development and Needs Assessment and Efficiency of Smart Communication System for Patients With ALS. NCT03787420 | Taipei Veterans General Hospital, Taiwan | N/A |
| Completed | A Study to Evaluate Transplantation of Astrocytes Derived From Human Embryonic Stem Cells, in Patients With Am NCT03482050 | Kadimastem | Phase 1 / Phase 2 |
| Unknown | Chromatic Pupillometry to Assess the Melanopsin-Light Pathway in Progressive Supranuclear Palsy NCT03330353 | Massachusetts General Hospital | — |
| Unknown | Music Therapy Protocol to Support Bulbar and Respiratory Functions in ALS NCT03604822 | Alisa Apreleva | N/A |
| Recruiting | The Swedish BioFINDER 2 Study NCT03174938 | Skane University Hospital | N/A |
| Completed | Safety and Feasibility of the EyeControl Device NCT02891629 | Eyefree Assisting Communication Ltd | N/A |
| Unknown | T-Regulatory Cells in Amyotrophic Lateral Sclerosis NCT03241784 | Stanley H. Appel, MD | Phase 1 |
| Completed | ALS Reversals - Lunasin Regimen NCT02709330 | Richard Bedlack, M.D., Ph.D. | Phase 2 |
| Recruiting | Impairments of Neuro-muscular Communication in Motor-Neuron Disease: A Bio-Marker for Early and Personalised D NCT05663008 | University of Dublin, Trinity College | — |
| Unknown | A Programme for Amyotrophic Lateral Sclerosis Care in Europe NCT03081338 | Sheffield Teaching Hospitals NHS Foundation Trust | — |
| Unknown | Intramuscular Infusion of Autologous Bone Marrow Stem Cells in Patients With Amyotrophic Lateral Sclerosis NCT02286011 | Red de Terapia Celular | Phase 1 |
| Terminated | Prognostic Value of a Diaphragmatic Endurance Test in Patients With Amyotrophic Lateral Sclerosis NCT02528071 | Centre Hospitalier Universitaire de Saint Etienne | — |
| Recruiting | ALS Research Collaborative NCT06885918 | ALS Therapy Development Institute | — |
| Completed | Focal Accumulation of Iron in Cerebral Regions in Early ALS (Amyotrophic Lateral Sclerosis) Patients NCT02164253 | University Hospital, Lille | Phase 2 |
| Completed | A Clinical Demonstration of EEG Brain-computer Interface for ALS Patients NCT00786032 | US Department of Veterans Affairs | — |
| Available | Intermediate-size Patient Population Expanded Access Protocol NCT07088159 | Spinogenix | — |