NCT07536516

Measurement of Ocular Blood Flow and Retinal Oxygen Extraction in Diabetic Patients

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The prevalence of diabetes is increasing, with type 2 diabetes mellitus comprising over 90% of cases. Diabetes mellitus complications, including diabetic retinopathy (DR), impose significant health burdens. GLP-1 receptor agonists (GLP-1RAs) and dual GIP/GLP-1 receptor agonists show promise in improving cardiovascular and kidney outcomes, but their effects on retinal microvasculature and neuroprotection remain unclear. This study investigates the impact of GLP-1RAs (semaglutide, liraglutide) and GIP/GLP-1-dual agonists (tirzepatide) on ocular blood flow and retinal function in DM patients.

Conditions

• Diabetes Mellitus

Interventions

Type	Name	Description
DEVICE	• Laser Speckle Flowgraphy (LSFG)	Laser Speckle Flowgraphy (LSFG)
DEVICE	• Optical Coherence Tomography (OCT)	• Optical Coherence Tomography (OCT)
DEVICE	• Optical Coherence Tomography Angiography (OCT-A)	• Optical Coherence Tomography Angiography (OCT-A)

Timeline

• Start date: 2025-11-28
• Primary completion: 2026-05-01
• Completion: 2026-06-01
• First posted: 2026-04-17
• Last updated: 2026-04-17

Locations

1 site across 1 country: Austria