NCT07535008

Dental Cleaning to Prevent Chronic Graft-Versus-Host Disease

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (estimated)
• Sponsor: Fred Hutchinson Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial evaluates the feasibility and effectiveness of a post-transplant dental cleaning for the prevention of chronic graft versus host disease (GVHD) in patients undergoing an allogeneic hematopoietic cell transplant (HCT). HCT is the only curative treatment for some types of blood cancer. Unfortunately, this approach can lead to the development of GVHD, which is a disease caused when cells from a donated stem cell graft attack the normal tissue of the transplant patient. Some research has shown that the bacteria that is present in the dental plaque soon after transplant may affect the development of chronic GVHD. Dental cleanings prior to transplant are part of the normal standard of care for patients undergoing HCT. Adding an additional cleaning shortly after HCT may be effective for preventing the development of chronic GVHD.

Detailed description

OUTLINE: Patients who have not undergone dental cleaning within 3 months preceding the baseline visit undergo dental cleaning at baseline (before the initiation of transplant conditioning) according to standard of care. All patients undergo simplified dental cleaning on day +28 following HCT. After completion of study intervention, patients are followed up on days +84 and +180 and at 1 year.

Conditions

• Chronic Graft Versus Host Disease
• Acute Graft Versus Host Disease
• Hematopoietic and Lymphatic System Neoplasm

Interventions

Type	Name	Description
PROCEDURE	Dental Cleaning	Dental cleaning
PROCEDURE	Dental Plaque sampling	Ancillary studies

Timeline

• Start date: 2026-05-01
• Primary completion: 2028-04-30
• Completion: 2029-04-30
• First posted: 2026-04-16
• Last updated: 2026-04-16

Locations

1 site across 1 country: United States