NCT07534553

Mechanical Power Ventilation in RALP

Mechanical Power-Targeted Ventilation in Robot-Assisted Laparoscopic Radical Prostatectomy: A Prospective Randomized Controlled Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Ankara City Hospital Bilkent · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Robot-assisted laparoscopic radical prostatectomy (RALP) requires steep Trendelenburg positioning and pneumoperitoneum, which adversely affect respiratory mechanics and may lead to impaired postoperative oxygenation. Mechanical power (MP) has recently emerged as a comprehensive parameter reflecting the total energy delivered from the ventilator to the respiratory system and may be associated with ventilator-induced lung injury. This prospective randomized controlled trial aims to evaluate whether a mechanical power-targeted ventilation strategy improves postoperative oxygenation compared to standard ventilation in patients undergoing RALP. The primary outcome is the oxygenation index (OSI) at the postoperative second hour. Secondary outcomes include PaO₂/FiO₂ ratio, postoperative pulmonary complications, and length of hospital stay.

Conditions

• Postoperative Pulmonary Dysfunction
• Oxygenation Impairment
• Robot-Assisted Radical Prostatectomy

Interventions

Type	Name	Description
PROCEDURE	Mechanical Power-Targeted Ventilation	Ventilation adjusted to achieve the lowest possible mechanical power (≤14 J/min) using titration of PEEP and respiratory rate.
PROCEDURE	Standard Ventilation	Conventional ventilation strategy with fixed PEEP (5 cmH₂O) and routine settings.

Timeline

• Start date: 2026-04-15
• Primary completion: 2026-06-01
• Completion: 2026-07-30
• First posted: 2026-04-16
• Last updated: 2026-04-16

Locations

1 site across 1 country: Turkey (Türkiye)