NCT07534293

Effects of 7-Day Creatine Supplementation on Cognitive Function After High-Intensity Interval Training in Active Young Men

Creatine Monohydrate Supplementation Preserves Cognitive Function in Student Athletes Following High Intensity Interval Training: Implications for Academic Performance

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Universitas Negeri Malang · Academic / Other
• Sex: Male
• Age: 19 Years – 25 Years
• Healthy volunteers: Accepted

Summary

This study evaluates whether 7-day creatine monohydrate supplementation affects cognitive function after high-intensity interval training (HIIT) in active young men. Twenty participants were assigned to one of four groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, or creatine 0.3 g/KgBW/day plus exercise. Cognitive performance was measured before and after the intervention using visual reaction time, go/no-go visual reaction time, and Trail Making Tests A and B.

Detailed description

This study used a controlled pretest-posttest, four-arm interventional design to examine the effects of short-term creatine monohydrate supplementation on cognitive function after high-intensity interval training (HIIT) in active young men. Twenty participants were allocated into four groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, and creatine 0.3 g/KgBW/day plus exercise. The intervention lasted 7 days. Participants in the exercise groups completed a bodyweight HIIT protocol consisting of two rounds. Round 1 used 40 seconds of work and 20 seconds of rest, and round 2 used 30 seconds of work and 15 seconds of rest, with 30 seconds of rest between rounds. The session included 14 sequential movements and was preceded by a 5-minute warm-up and followed by a 5-minute cool-down. Cognitive performance was assessed before and after the intervention using visual reaction time (VRT), go/no-go visual reaction time (GNGVRT), and Trail Making Test Parts A and B. These measures were selected to capture processing speed, inhibitory control, attention, and executive function. The study was approved by the ethics committee of Universitas Negeri Malang, and written informed consent was obtained from all participants.

Conditions

• Creatine Supplementation
• Exercise Ergogenics

Interventions

Type	Name	Description
DRUG	Creatine Monohydrate	Creatine monohydrate supplementation at a dose of 0,1 g/KgBW/day for 7 days.
DRUG	Creatine Monohydrate	Creatine monohydrate supplementation at a dose of 0,3 g/KgBW/day for 7 days.
DRUG	Placebo	Placebo supplementation for 7 days
BEHAVIORAL	High Intensity Interval Training	A bodyweight high-intensity interval training program performed in 2 rounds with 40 seconds work and 20 seconds rest in round 1, and 30 seconds work and 15 seconds rest in round 2, with 30 seconds rest between rounds.

Timeline

• Start date: 2026-02-07
• Primary completion: 2026-02-14
• Completion: 2026-02-14
• First posted: 2026-04-16
• Last updated: 2026-04-16

Locations

1 site across 1 country: Indonesia