NCT07534176

To Evaluate the Impact of Smoking on PK After Single-dose Oral Administration of GS1-144 Tablets .

A Drug-Drug Interaction Study to Evaluate the Effect of Smoking (CYP1A2 Inducer) on the Pharmacokinetics Following a Single Oral Dose of GS1-144 Tablets in Chinese Healthy Postmenopausal Female Trial Participants

• Status: Not Yet Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: Changchun GeneScience Pharmaceutical Co., Ltd. · Industry
• Sex: Female
• Age: 40 Years – 65 Years
• Healthy volunteers: Accepted

Summary

A Drug-Drug Interaction Study to Evaluate the Effect of Smoking (CYP1A2 Inducer) on the Pharmacokinetics Following a Single Oral Dose of GS1-144 Tablets in Chinese Healthy Postmenopausal Female Trial Participants

Detailed description

This drug-drug interaction study adopts an open-label, parallel design to evaluate the effect of smoking on the PK following a single oral dose of GS1-144 tablets in Chinese healthy postmenopausal female trial participants.

Conditions

• Postmenopause

Interventions

Type	Name	Description
DRUG	GS1-144 tablets	All trial participants will receive the investigational drug (GS1-144 tablets) at a dose of 30 mg.

Timeline

• Start date: 2026-05-27
• Primary completion: 2026-10-20
• Completion: 2027-02-08
• First posted: 2026-04-16
• Last updated: 2026-04-16

Locations

1 site across 1 country: China