NCT07531576

Outcome of Primary vs Delayed Primary Closure of Laparotomy in Dirty Abdominal Wounds

Outcome of Primary vs Delayed Primary Closure of Laparotomy in Dirty Abdominal Wounds: A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 78 (actual)
• Sponsor: Ayub Teaching Hospital · Academic / Other
• Sex: All
• Age: 15 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This randomized controlled trial is designed to evaluate and compare two different wound management strategies-primary closure (PC) and delayed primary closure (DPC)-in patients undergoing emergency laparotomy for peritonitis * The primary objective is to determine which technique more effectively reduces postoperative complications, specifically surgical site infections (SSI) and wound dehiscence (burst abdomen), while also assessing the impact on the length of hospital stay (LOS) The study includes 78 patients aged 15 to 80 years with free intraperitoneal contamination * In the PC group, the abdominal wound is closed immediately following the procedure * In the DPC group, the skin and subcutaneous tissues are initially left open to allow for drainage and are washed twice weekly until the wound is free of contamination (pus, fecal matter, bile, or blood), at which point it is closed using tension sutures * This study aims to provide clinical evidence on whether the biological benefits of DPC-such as reduced bacterial colonization and improved drainage-outweigh the potential drawbacks of the technique, such as patient discomfort or prolonged care

Conditions

• Peritonitis
• Primary Closure
• Delayed Primary Closure

Interventions

Type	Name	Description
PROCEDURE	Delayed Primary Laparotomy wound Closure	This technique involves leaving the skin and subcutaneous tissues open for several days following the initial surgery
PROCEDURE	Primary Abdominal Closure	In this intervention, the skin and subcutaneous tissues are closed immediately following the completion of the emergency laparotomy

Timeline

• Start date: 2021-02-17
• Primary completion: 2021-06-21
• Completion: 2021-06-21
• First posted: 2026-04-15
• Last updated: 2026-04-15

Locations

1 site across 1 country: Pakistan